Clinical risk factors for primary graft dysfunction after lung transplantation
Joshua M Diamond, James C Lee, Steven M Kawut, Rupal J Shah, A Russell Localio, Scarlett L Bellamy, David J Lederer, Edward Cantu, Benjamin A Kohl, Vibha N Lama, Sangeeta M Bhorade, Maria Crespo, Ejigayehu Demissie, Joshua Sonett, Keith Wille, Jonathan Orens, Ashish S Shah, Ann Weinacker, Selim Arcasoy, Pali D Shah, David S Wilkes, Lorraine B Ware, Scott M Palmer, Jason D Christie, Lung Transplant Outcomes Group, Jason Christie, Steven M Kawut, Alberto Pocchetino, Y Joseph Woo, Ejigayehu Demissie, Robert M Kotloff, Vivek N Ahya, James Lee, Denis Hadjiliadis, Melanie Rushefski, Richard Aplenc, Clifford Deutschman, Benjamin Kohl, Edward Cantu, Joshua M Diamond, Rupal J Shah, Laurel Kalman, David Lederer, Selim Arcasoy, Joshua Sonett, Jessie Wilt, Frank D'Ovidio, Lori Shah, Hilary Robbins, Matthew Bacchetta, Nilani Ravichandran, Genevieve Reilly, Jeffrey Okun, Debbie Rybak, Michael Koeckert, Robert Sorabella, Nisha Ann Philip, Nadine Al-Naamani, Matthew LaVelle, Megan Larkin, Shefali Sanyal, Lorraine Ware, Aaron Milstone, Jean Barnes, Stephanie Logan, Carla Ramsey, Thelma Walden, Shaquita Claybrooks, Ann Weinacker, Susan Spencer Jacobs, Val Scott, Tal Alfasi, Keith Wille, Necole Harris, Jonathan Orens, Ashish Shah, John McDyer, Christian Merlo, Matthew Pipeling, Reda Girgis, Karen Oakjones, April Thurman, Vibha Lama, Fernando Martinez, Emily Galopin, Douglas R Armstrong, Mary Maliarik, Scott M Palmer, David Zaas, R Duane Davis, Ashley Finlen-Copeland, Jessica Martissa, William A Davis, Sangeeta Bhorade, Mark Lockwood, Maria Crespo, Joseph Pilewski, Christian Bermudez, Kathleen Hanze, David S Wilkes, David Wilson Roe, Thomas Wozniak, Ronda L McNamee, Kim A Fox, Danyel F Gooch, Tonya Isaacs, Joshua M Diamond, James C Lee, Steven M Kawut, Rupal J Shah, A Russell Localio, Scarlett L Bellamy, David J Lederer, Edward Cantu, Benjamin A Kohl, Vibha N Lama, Sangeeta M Bhorade, Maria Crespo, Ejigayehu Demissie, Joshua Sonett, Keith Wille, Jonathan Orens, Ashish S Shah, Ann Weinacker, Selim Arcasoy, Pali D Shah, David S Wilkes, Lorraine B Ware, Scott M Palmer, Jason D Christie, Lung Transplant Outcomes Group, Jason Christie, Steven M Kawut, Alberto Pocchetino, Y Joseph Woo, Ejigayehu Demissie, Robert M Kotloff, Vivek N Ahya, James Lee, Denis Hadjiliadis, Melanie Rushefski, Richard Aplenc, Clifford Deutschman, Benjamin Kohl, Edward Cantu, Joshua M Diamond, Rupal J Shah, Laurel Kalman, David Lederer, Selim Arcasoy, Joshua Sonett, Jessie Wilt, Frank D'Ovidio, Lori Shah, Hilary Robbins, Matthew Bacchetta, Nilani Ravichandran, Genevieve Reilly, Jeffrey Okun, Debbie Rybak, Michael Koeckert, Robert Sorabella, Nisha Ann Philip, Nadine Al-Naamani, Matthew LaVelle, Megan Larkin, Shefali Sanyal, Lorraine Ware, Aaron Milstone, Jean Barnes, Stephanie Logan, Carla Ramsey, Thelma Walden, Shaquita Claybrooks, Ann Weinacker, Susan Spencer Jacobs, Val Scott, Tal Alfasi, Keith Wille, Necole Harris, Jonathan Orens, Ashish Shah, John McDyer, Christian Merlo, Matthew Pipeling, Reda Girgis, Karen Oakjones, April Thurman, Vibha Lama, Fernando Martinez, Emily Galopin, Douglas R Armstrong, Mary Maliarik, Scott M Palmer, David Zaas, R Duane Davis, Ashley Finlen-Copeland, Jessica Martissa, William A Davis, Sangeeta Bhorade, Mark Lockwood, Maria Crespo, Joseph Pilewski, Christian Bermudez, Kathleen Hanze, David S Wilkes, David Wilson Roe, Thomas Wozniak, Ronda L McNamee, Kim A Fox, Danyel F Gooch, Tonya Isaacs
Abstract
Rationale: Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors.
Objectives: We sought to identify donor, recipient, and perioperative risk factors for PGD.
Methods: We performed a 10-center prospective cohort study enrolled between March 2002 and December 2010 (the Lung Transplant Outcomes Group). The primary outcome was International Society for Heart and Lung Transplantation grade 3 PGD at 48 or 72 hours post-transplant. The association of potential risk factors with PGD was analyzed using multivariable conditional logistic regression.
Measurements and main results: A total of 1,255 patients from 10 centers were enrolled; 211 subjects (16.8%) developed grade 3 PGD. In multivariable models, independent risk factors for PGD were any history of donor smoking (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.2-2.6; P = 0.002); FiO2 during allograft reperfusion (OR, 1.1 per 10% increase in FiO2; 95% CI, 1.0-1.2; P = 0.01); single lung transplant (OR, 2; 95% CI, 1.2-3.3; P = 0.008); use of cardiopulmonary bypass (OR, 3.4; 95% CI, 2.2-5.3; P < 0.001); overweight (OR, 1.8; 95% CI, 1.2-2.7; P = 0.01) and obese (OR, 2.3; 95% CI, 1.3-3.9; P = 0.004) recipient body mass index; preoperative sarcoidosis (OR, 2.5; 95% CI, 1.1-5.6; P = 0.03) or pulmonary arterial hypertension (OR, 3.5; 95% CI, 1.6-7.7; P = 0.002); and mean pulmonary artery pressure (OR, 1.3 per 10 mm Hg increase; 95% CI, 1.1-1.5; P < 0.001). PGD was significantly associated with 90-day (relative risk, 4.8; absolute risk increase, 18%; P < 0.001) and 1-year (relative risk, 3; absolute risk increase, 23%; P < 0.001) mortality.
Conclusions: We identified grade 3 PGD risk factors, several of which are potentially modifiable and should be prioritized for future research aimed at preventative strategies. Clinical trial registered with www.clinicaltrials.gov (NCT 00552357).
Trial registration: ClinicalTrials.gov NCT00552357.
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Source: PubMed