Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk
Thomas Lecompte, Denis Wahl, Christine Perret-Guillaume, H Coenraad Hemker, Patrick Lacolley, Véronique Regnault, Thomas Lecompte, Denis Wahl, Christine Perret-Guillaume, H Coenraad Hemker, Patrick Lacolley, Véronique Regnault
Abstract
Interference of antiphospholipid antibodies (aPL) with coagulation was investigated in 40 aPL-patients (24 with thrombosis) using thrombography. Impairment of the activated protein C anticoagulant pathway was partially offset by the genuine anticoagulant effect. The net result, a procoagulant phenotype, was associated with a 7-fold increased risk of thrombosis in aPL-patients.
Source: PubMed