Serum inflammatory mediators correlate with disease activity in electrical status epilepticus in sleep (ESES) syndrome
Bart van den Munckhof, Evelien E de Vries, Kees P J Braun, H Myrthe Boss, Michèl A Willemsen, Annet van Royen-Kerkhof, Wilco de Jager, Floor E Jansen, Bart van den Munckhof, Evelien E de Vries, Kees P J Braun, H Myrthe Boss, Michèl A Willemsen, Annet van Royen-Kerkhof, Wilco de Jager, Floor E Jansen
Abstract
We aimed to study serum cytokine levels in 11 electrical status epilepticus in sleep (ESES) patients and 20 healthy control children. Patients showed significantly higher levels of interleukin (IL)-1α, IL-6, IL-10, chemokine (C-C motif) ligand (CCL)2 and chemokine (C-X-C motif) ligand (CXCL)8/IL-8 than controls, while macrophage migration inhibitory factor (MIF) and CCL3 were significantly lower. Follow-up analyses in five patients revealed a significant decrease of IL-6 levels after immunomodulating treatment. IL-6 changes were accompanied by clear improvement of electroencephalography (EEG) patterns and neuropsychological evaluation. We hypothesize that IL-6 correlates with disease activity and immunomodulating treatment efficacy.
Keywords: CSWS; Continuous spikes and waves during sleep; Cytokines; ESES; Electrical status epilepticus during sleep; Landau-Kleffner syndrome.
Wiley Periodicals, Inc. © 2015 International League Against Epilepsy.
Source: PubMed