Scintimammography with a hybrid SPECT/CT imaging system
Orazio Schillaci, Roberta Danieli, Luca Filippi, Pasquale Romano, Elsa Cossu, Carlo Manni, Giovanni Simonetti, Orazio Schillaci, Roberta Danieli, Luca Filippi, Pasquale Romano, Elsa Cossu, Carlo Manni, Giovanni Simonetti
Abstract
Background: Planar scintimammography is useful for characterizing breast lesions >10 mm. Our aim was to evaluate Tc-99m sestamibi scintimammography with a hybrid (SPECTICT) device for functional anatomical mapping (FAM).
Patients and methods: Three planar images and a chest SPECT/CT were performed with a hybrid device in 53 patients with mammographically suspicious lesions. The final histopathological diagnosis was obtained after surgery.
Results: The planar images were positive in 27 out of 37 carcinomas (sensitivity 73%) and the SPECT/CT in 33 (sensitivity 89.2%). The sensitivity of planar imaging and SPECT/CT was 42.9% and 71.4% in cancers < or =10 mm, and 91.3%, and 100% in cancers >10 mm, respectively. The specificity was 93.8% for both planar and SPECT/CT imaging; accuracy was 79.2% for planar scans and 90.6% for SPECT/CT. FAM was useful in providing a precise anatomical localisation of the SPECT findings.
Conclusion: SPECT/CT scintimammography using a hybrid device is able to detect breast cancer, showing a sensitivity higher than that of planar images, especially for small cancers.
Source: PubMed