Research and therapeutics-traditional and emerging therapies in systemic lupus erythematosus
Laurie S Davis, Andreas M Reimold, Laurie S Davis, Andreas M Reimold
Abstract
This review summarizes traditional and emerging therapies for SLE. Evidence suggests that the heterogeneity of SLE is a crucial aspect contributing to the failure of large clinical trials for new targeted therapies. A clearer understanding of the mechanisms driving disease pathogenesis combined with recent advances in medical science are predicted to enable accelerated progress towards improved SLE diagnosis and personalized approaches to treatment.
Keywords: B cells; biological therapies; clinical trials and methods; immunotherapy; systemic lupus erythematosus and autoimmunity.
© The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Source: PubMed