Translating tDCS into the field of obesity: mechanism-driven approaches

Miguel Alonso-Alonso, Miguel Alonso-Alonso

Abstract

Transcranial direct current stimulation (tDCS) is emerging as a promising technique for neuromodulation in a variety of clinical conditions. Recent neuroimaging studies suggest that modifying the activity of brain circuits involved in eating behavior could provide therapeutic benefits in obesity. One session of tDCS over the dorsolateral prefrontal cortex can induce an acute decrease in food craving, according to three small clinical trials, but the extension of these findings into the field of obesity remains unexplored. Importantly, there has been little/no interaction of our current understanding of tDCS and its mechanisms with obesity-related research. How can we start closing this gap and rationally guide the translation of tDCS into the field of obesity? In this mini-review I summarize some of the challenges and questions ahead, related to basic science and technical aspects, and suggest future directions.

Keywords: inhibitory control; obesity; prefrontal cortex; transcranial direct current stimulation; weight loss.

References

    1. Appelhans B. M. (2009). Neurobehavioral inhibition of reward-driven feeding: implications for dieting and obesity. Obesity (Silver Spring) 17, 640–647 10.1038/oby.2008.638
    1. Binkofski F., Loebig M., Jauch-Chara K., Bergmann S., Melchert U. H., Scholand-Engler H. G., et al. (2011). Brain energy consumption induced by electrical stimulation promotes systemic glucose uptake. Biol. Psychiatry 70, 690–695 10.1016/j.biopsych.2011.05.009
    1. Brooks S. J., Cedernaes J., Schioth H. B. (2013). Increased prefrontal and parahippocampal activation with reduced dorsolateral prefrontal and insular cortex activation to food images in obesity: a meta-analysis of fMRI studies. PLoS One 8:e60393 10.1371/journal.pone.0060393
    1. Cantello R., Varrasi C., Tarletti R., Cecchin M., D’andrea F., Veggiotti P., et al. (2007). Ketogenic diet: electrophysiological effects on the normal human cortex. Epilepsia 48, 1756–1763 10.1111/j.1528-1167.2007.01156.x
    1. Carnell S., Gibson C., Benson L., Ochner C. N., Geliebter A. (2012). Neuroimaging and obesity: current knowledge and future directions. Obes. Rev. 13, 43–56 10.1111/j.1467-789x.2011.00927.x
    1. Chambers C. D., Garavan H., Bellgrove M. A. (2009). Insights into the neural basis of response inhibition from cognitive and clinical neuroscience. Neurosci. Biobehav. Rev. 33, 631–646 10.1016/j.neubiorev.2008.08.016
    1. DelParigi A., Chen K., Salbe A. D., Hill J. O., Wing R. R., Reiman E. M., et al. (2007). Successful dieters have increased neural activity in cortical areas involved in the control of behavior. Int. J. Obes. (Lond) 31, 440–448 10.1038/sj.ijo.0803431
    1. Ditye T., Jacobson L., Walsh V., Lavidor M. (2012). Modulating behavioral inhibition by tDCS combined with cognitive training. Exp. Brain Res. 219, 363–368 10.1007/s00221-012-3098-4
    1. Fabricatore A. N., Wadden T. A. (2006). Obesity. Annu. Rev. Clin. Psychol. 2, 357–377
    1. FDA (2007). Guidance for industry developing products for weight management: draft guidance. Fed. Reg. 72, 7441–7442
    1. Fregni F., Orsati F., Pedrosa W., Fecteau S., Tome F. A., Nitsche M. A., et al. (2008). Transcranial direct current stimulation of the prefrontal cortex modulates the desire for specific foods. Appetite 51, 34–41 10.1016/j.appet.2007.09.016
    1. Goldman R. L., Borckardt J. J., Frohman H. A., O’neil P. M., Madan A., Campbell L. K., et al. (2011). Prefrontal cortex transcranial direct current stimulation (tDCS) temporarily reduces food cravings and increases the self-reported ability to resist food in adults with frequent food craving. Appetite 56, 741–746 10.1016/j.appet.2011.02.013
    1. Halpern C. H., Torres N., Hurtig H. I., Wolf J. A., Stephen J., Oh M. Y., et al. (2011). Expanding applications of deep brain stimulation: a potential therapeutic role in obesity and addiction management. Acta Neurochir. (Wien) 153, 2293–2306 10.1007/s00701-011-1166-3
    1. Houben K. (2011). Overcoming the urge to splurge: influencing eating behavior by manipulating inhibitory control. J. Behav. Ther. Exp. Psychiatry 42, 384–388 10.1016/j.jbtep.2011.02.008
    1. Juan C. H., Muggleton N. G. (2012). Brain stimulation and inhibitory control. Brain Stimul. 5, 63–69 10.1016/j.brs.2012.03.012
    1. McCaffery J. M., Haley A. P., Sweet L. H., Phelan S., Raynor H. A., Del Parigi A., et al. (2009). Differential functional magnetic resonance imaging response to food pictures in successful weight-loss maintainers relative to normal-weight and obese controls. Am. J. Clin. Nutr. 90, 928–934 10.3945/ajcn.2009.27924
    1. Montenegro R. A., Okano A. H., Cunha F. A., Gurgel J. L., Fontes E. B., Farinatti P. T. (2012). Prefrontal cortex transcranial direct current stimulation associated with aerobic exercise change aspects of appetite sensation in overweight adults. Appetite 58, 333–338 10.1016/j.appet.2011.11.008
    1. Nitsche M. A., Liebetanz D., Schlitterlau A., Henschke U., Fricke K., Frommann K., et al. (2004). GABAergic modulation of DC stimulation-induced motor cortex excitability shifts in humans. Eur. J. Neurosci. 19, 2720–2726 10.1111/j.0953-816x.2004.03398.x
    1. Rosenbaum M., Sy M., Pavlovich K., Leibel R. L., Hirsch J. (2008). Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J. Clin. Invest. 118, 2583–2591 10.1172/jci35055
    1. Silvanto J., Muggleton N., Walsh V. (2008). State-dependency in brain stimulation studies of perception and cognition. Trends Cogn. Sci. 12, 447–454 10.1016/j.tics.2008.09.004
    1. Stagg C. J., Nitsche M. A. (2011). Physiological basis of transcranial direct current stimulation. Neuroscientist 17, 37–53 10.1177/1073858410386614
    1. Tataranni P. A., Gautier J. F., Chen K., Uecker A., Bandy D., Salbe A. D., et al. (1999). Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography. Proc. Natl. Acad. Sci. U S A 96, 4569–4574 10.1073/pnas.96.8.4569
    1. Truong D. Q., Magerowski G., Blackburn G. L., Bikson M., Alonso-Alonso M. (2013). Computational modeling of transcranial direct current stimulation (tDCS) in obesity: impact of head fat and dose guidelines. Neuroimage (Amst) 2, 759–766 10.1016/j.nicl.2013.05.011
    1. Truong D. Q., Magerowski G., Pascual-Leone A., Alonso-Alonso M., Bikson M. (2012). Finite element study of skin and fat delineation in an obese subject for transcranial direct current stimulation. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2012, 6587–6590 10.1109/embc.2012.6347504
    1. Vainik U., Dagher A., Dube L., Fellows L. K. (2013). Neurobehavioural correlates of body mass index and eating behaviours in adults: a systematic review. Neurosci. Biobehav. Rev. 37, 279–299 10.1016/j.neubiorev.2012.11.008
    1. Yokum S., Ng J., Stice E. (2012). Relation of regional gray and white matter volumes to current BMI and future increases in BMI: a prospective MRI study. Int. J. Obes. (Lond) 36, 656–664 10.1038/ijo.2011.175

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