Mineral Intake and Status of Cow's Milk Allergic Infants Consuming an Amino Acid-based Formula

Bryan M Harvey, Simone R B M Eussen, Lucien F Harthoorn, A Wesley Burks, Bryan M Harvey, Simone R B M Eussen, Lucien F Harthoorn, A Wesley Burks

Abstract

Data on the mineral status of infants with cow's milk allergy (CMA) consuming an amino acid-based formula (AAF) have not been published. The present study aims to assess mineral status of term infants age 0 to 8 months diagnosed with CMA receiving an AAF for 16 weeks. Serum concentrations of calcium, phosphorus, chloride, sodium, potassium, magnesium, and ferritin were determined in 82 subjects at baseline and in 66 subjects after 16 weeks on AAF using standard methods and evaluated against age-specific reference ranges. In addition to this, individual estimated energy and mineral intakes were compared to Adequate Intakes defined by the European Food Safety Authority and the US Institute of Medicine. The results of this study show that the AAF was effective in providing an adequate mineral status in infants with CMA. The vast majority of infants aged 0 to 6 months (formula only) and aged 6 to 12 months (formula and complementary foods) had adequate mineral intakes.

Conflict of interest statement

S.R.B.M.E. and L.F.H. are employees of Nutricia Research. A.W.B. received grants from the National Institutes of Health (NIH; Bethesda, MD), Wallace Research Foundation, and Nutricia North America and is consultant for Merck and McNeill Nutritionals. B.M.H. declares no conflict of interest.

References

    1. Fiocchi A, Brozek J, Schunemann H, et al. World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines. World Allergy Organ J 2010; 3:57–161.
    1. Vandenplas Y, Koletzko S, Isolauri E, et al. Guidelines for the diagnosis and management of cow's milk protein allergy in infants. Arch Dis Child 2007; 92:902–908.
    1. Burks AW, Harthoorn LF, Van Ampting MT, et al. Synbiotics-supplemented amino acid-based formula supports adequate growth in cow's milk allergic infants. Pediatr Allergy Immunol 2015; 26:316–322.
    1. Harvey BM, Langford JE, Harthoorn LF, et al. Effects on growth and tolerance and hypoallergenicity of an amino acid-based formula with synbiotics. Pediatr Res 2014; 75:343–351.
    1. Niggemann B, Binder C, Dupont C, et al. Prospective, controlled, multi-center study on the effect of an amino-acid-based formula in infants with cow's milk allergy/intolerance and atopic dermatitis. Pediatr Allergy Immunol 2001; 12:78–82.
    1. Mofidi S. Nutritional management of pediatric food hypersensitivity. Pediatrics 2003; 111 (6 pt 3):1645–1653.
    1. Duggan C, Watkins JB, Walker WA. Nutrition in Pediatrics. Ontario, Canada: BC Decker Inc Hamilton; 2008.
    1. Scientific Advisory Committee on Nutrition (SACN). Dietary Reference Values for Energy. London, UK: The Stationery Office (TSO); 2011.
    1. US Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, D.C: The National Academies; 2005.
    1. van Rossum CTM, Fransen HP, Verkaik-Kloosterman J, et al. Dutch National Food Consumption Survey 2007–2010. Diet of children and adults aged 7 to 69 years. Bilthoven, The Netherlands: National Institute for Public Health and the Environment; 2011.
    1. EFSA Panel on Dietetic Products Nutrition and Allergies (NDA). Scientific Opinion on Dietary Reference Values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol. EFSA J 2010; 8:1461.
    1. US Institute of Medicine. Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Washington, DC: T.N. Academies; 2006.
    1. The National Academies, US Institute of Medicine. Dietary Reference Intakes for Calcium and Vitamin D. 2011.
    1. Bates B, Lennox A, Swan eds G. NatCen/UCL/MRC NatCen/UCL/MRC, National Diet and Nutrition Survey Year 1 and 2 of Rolling Program, 2008–2010. London, UK: 2011.
    1. HMSO, Department of Health. Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report of the Panel on Dietary Reference Values of the Committee on Medical Aspects of Food Policy. Report on Health and Social Subjects. 1991; London, UK,
    1. Joint FAO/WHO Expert Consultation on Human Vitamin and Mineral Requirements. Vitamin and Mineral Requirements in Human Nutrition. Geneva, Switzerland: World Health Organization and Food and Agriculture Organization of the United Nations; 2004.
    1. Scientific Committee on Food, Scientific Panel on Dietetic Products, Nutrition and Allergies. Tolerable Upper Intake Levels for Vitamins and Minerals. Parma, Italy: European Food Safety Authority; 2006.
    1. Szymlek-Gay EA, Ferguson EL, Heath AL, et al. Food-based strategies improve iron status in toddlers: a randomized controlled trial. Am J Clin Nutr 2009; 90:1541–1551.
    1. WHO/UNICEF/UNU. Iron Deficiency Anaemia—Assessment, Prevention and Control. A Guide for Programme Managers. 2001; Geneva, Switzerland: WHO/UNICEF/UNU, 1–132.
    1. Eussen S, Alles M, Uijterschout L, et al. Iron intake and status of children aged 6–36 months in Europe: a systematic review. Ann Nutr Metab 2015; 66:80–92.
    1. US Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride. Washington, D.C: The National Academies; 1997.

Source: PubMed

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