Effect of PGX, a novel functional fibre supplement, on subjective ratings of appetite in overweight and obese women consuming a 3-day structured, low-calorie diet

V Kacinik, M Lyon, M Purnama, R A Reimer, R Gahler, T J Green, S Wood, V Kacinik, M Lyon, M Purnama, R A Reimer, R Gahler, T J Green, S Wood

Abstract

Introduction: Dietary factors that help control perceived hunger might improve adherence to calorie-reduced diets.

Objectives: The objective of the study was to investigate the effect of supplementing a three-day, low-calorie diet with PolyGlycopleX (PGX), a highly viscous fibre, on subjective ratings of appetite compared with a placebo.

Methods: In a double-blind crossover design with a 3-week washout, 45 women (aged 38±9 years, body mass index 29.9±2.8 kg m(-2)) were randomised to consume a 1000-kcal per day diet for 3 days, supplemented with 5 g of PGX or placebo at each of breakfast, lunch and dinner. Subjective appetite was assessed using 100 mm visual analogue scales that were completed daily before, between and after consumption of meals.

Results: Thirty-five women completed the study. Consumption of PGX compared with placebo led to significantly lower mean area under the curve for hunger on day 3 (440.4 versus 375.4; P=0.048), prospective consumption on day 3 (471.0 versus 401.8; P=0.017) and the overall 3-day average (468.6 versus 420.2; P=0.026). More specifically, on day 3 PGX significantly reduced total appetite, hunger, desire to eat and prospective consumption for 2.5 and 4.5 h after lunch and before dinner times, with hunger also being reduced 2.5 h after dinner (P<0.05).

Conclusion: The results show that adding 5 g of PGX to meals during consumption of a low-calorie diet reduces subjective ratings of prospective consumption and increases the feelings of satiety, especially during afternoon and evening. This highly viscous polysaccharide may be a useful adjunct to weight-loss interventions involving significant caloric reductions.

Figures

Figure 1
Figure 1
Comparison of 2.5 h post breakfast, lunch and dinner mean hunger and prospective consumption scores of day 3 of the 1000-kcal calorie diet supplement with either 5 g of PGX or placebo at each meal. Values shown are mean±s.e. (n=35). *Significantly lower scores with PGX than with the placebo supplement (P<0.05).
Figure 2
Figure 2
Comparison of the 4.5 h post lunch mean hunger and prospective consumption scores of day 3 of the 1000-kcal calorie diet supplement with either 5 g of PGX or placebo at each meal. Values shown are mean±s.e. (n=35). *Significantly lower scores with PGX than with the placebo supplement (P<0.05).
Figure 3
Figure 3
Comparison of predinner mean hunger and prospective consumption scores of day 3 of the 1000-kcal calorie diet supplement with either 5 g of PGX or placebo at each meal. Values shown are mean±s.e. (n=35). *Significantly lower scores with PGX than with the placebo supplement (P<0.05).

References

    1. Flegal KM, Graubard BI, Williamson DF, Gail MH. Excess deaths associated with underweight, overweight, and obesity. JAMA. 2005;293:1861–1867.
    1. Gregg EW, Cheng YJ, Cadwell BL, Imperatore G, Williams DE, Flegal KM, et al. Secular trends in cardiovascular disease risk factors according to body mass index in US adults. JAMA. 2005;293:1868–1874.
    1. Blackburn GL. Effect of degree of weight loss on health benefits. Obes Res. 1995;3:211S–216S.
    1. Hill JO. Understanding and addressing the epidemic of obesity: an energy balance perspective. Endocr Rev. 2006;27:750–761.
    1. National Heart, Lung, and Blood Institute Expert Panel on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults Executive summary of the clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. Arch Intern Med. 1998;158:1855–1867.
    1. Womble LG, Williamson DA, Greenway FL, Redmann SM. Psychological and behavioural predictors of weight loss during drug treatment for obesity. Int J Obes Relat Metab. 2001;25:340–345.
    1. Doucet E, St-Pierre S, Almeras N, Tremblay A. Relation between appetite ratings before and after a standard meal and estimates of daily energy intake in obese and reduced obese individuals. Appetite. 2003;40:137–143.
    1. Delzenne NM, Cani PD. A place for dietary fiber in the management of the metabolic syndrome. Curr Opin Clin Nutr Metab Care. 2005;8:636–640.
    1. Howarth NC, Saltzman E, Roberts SB. Dietary fiber and weight regulation. Nutr Rev. 2001;59:129–139.
    1. Wanders AJ, van den Borne JJGC, de Graff C, Hulshof T, Jonathan MC, Kristensen M, et al. Effects of dietary fibre on subjective appetite, energy intake and body weight: a systematic review of randomized controlled trial. Obes Rev. 2011;12:724–739.
    1. Mattes RD, Rothacker D. Beverage viscosity is inversely related to postprandial hunger in humans. Physiol Behavior. 2001;74:551–557.
    1. Delargy HJ, Burley VJ, O'Sullivan KR, Fletcher RJ, Blundell JE. Effects of different soluble: insoluble fiber ratios at breakfast on 24-h pattern of dietary intake and satiety. Eur J Clin Nutr. 1995;49:754–766.
    1. Delargy HJ, O'Sullivan KR, Fletcher RJ, Blundell JE. Effects of the amount and type of dietary fiber (soluble and insoluble) on short term control of appetite. Int J Food Sci Nutr. 1997;48:67–77.
    1. Chow JM, Choe YS, Noss MJ, Robinson KJ, Dugle JE, Acosta SH, et al. Effect of a viscous fiber-containing nutrition bar on satiety of patients with type 2 diabetes. Diabetes Res Clin Pract. 2007;76:335–340.
    1. Astrup A, Vrist E, Quaade F. Dietary fiber added to very low calorie diet reduces hunger and alleviates constipation. Int J Obes. 1990;14:105–112.
    1. Pasman WJ, Saris WHM, Wauters MAJ, Westerterp-Plantenga MS. Effect of one week fiber supplementation on hunger and satiety ratings and energy intake. Appetite. 1997;29:77–87.
    1. Jenkins DJ, Wolever TM, Leeds AR, Gassull MA, Haisman P, Dilawari J, et al. Dietary fibers, fiber analogues, and glucose tolerance: importance of viscosity. Br Med J. 1978;1:1392–1394.
    1. Ellis PR, Apling EC, Leeds AR, Bolster NR. Guar bread: acceptability and efficacy combined. Studies on blood glucose, serum insulin and satiety in normal subjects. Br J Nutr. 1981;46:267–276.
    1. Vuksan V, Panahi S, Lyon M, Rogovik A, Jenkins A, Leiter L. Viscosity of fiber preloads affects food intake in adolescents. Nutr Metab Cardiovasc Dis. 2009;19:498–503.
    1. Cappelleri JC, Bushmakin AG, Gerber RA, Leidy NK, Sexton CC, Lowe MR, et al. Psychometric analysis off the three-factor eating questionnaire-R21: results from a large diverse sample of obese and non-obese participants. Int J Obes. 2009;33:611–620.
    1. Blundell JE, Burley VJ. Satiation, satiety and the action of fiber on food intake. Int J Obes. 1987;11:9–25.
    1. Abdelhameed AS, Ang A, Morris GA, Smith I, Lawson C, Gahler R, et al. An analytical ultracentrifuge study on ternary mixtures of konjac glucomannan supplemented with sodium alginate and xanthan gum. Carbohydr Polym. 2010;81:141–148.
    1. Harding SE, Smith IH, Lawson CJ, Gahler RJ, Wood S. Studies on macromolecular interactions in ternary mixtures of konjac glucomannan, xanthan gum and sodium alginate. J Carbpol. 2010;10:1016–1020.
    1. Matulka R, Lyon M, Wood S, Marone P, Merkel D, Burdock G. The safety of PolyGlycopleX® (PGX®) as shown in a 90-day rodent feeding study. Nutr J. 2009;8:1–11.
    1. Carabin I, Lyon M, Wood S, Pelletier X, Donazzolo Y, Burdock G. Supplementation of the diet with the functional fiber PolyGlycoplex® is well tolerated by healthy subjects in a clinical trial. Nutr J. 2009;8:9.
    1. Marone P, Lyon M, Gahler R, Donath C, Hofman-Huther H, Wood S. Genotoxicity studies of PolyGlycopleX® (PGX®): a novel dietary fiber. Int J Toxicol. 2009;28:318–331.
    1. Boon H, Clitheroe J, Forte T. Effects of greens+®: a randomized, controlled trial. Can J Diet Prac Res. 2004;65:66–71.
    1. Bijkerk CJ, de Wit NJ, Muris JWM, Whorwell PJ, Knottnerus JA, Hoes AW. Soluble or insoluble fiber in irritable bowel syndrome in primary care? Randomised placebo controlled trial. Br Med J. 2009;339:b.3154.
    1. Niba LL. Processing effects on susceptibility of starch to digestion in some dietary starch sources. Int J Food Sci Nutr. 2003;54:97–109.
    1. Brennan IM, Feltrin KL, Nair NS, Hausken T, Little TJ, Gentilcore D, et al. Effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women. Am J Physiol Gastrointest Liver Physiol. 2009;297:G602–G610.
    1. Stubbs RJ, Hughes DAQ, Johnstone AM, Rowley E, Reid C, Elia M, et al. The use of visual analogue scales to assess motivation to eat in human subjects: a review of their reliability and validity with an evaluation of new hand-held computerized systems for temporal tracking of appetite ratings. Br J Nutr. 2000;84:405–415.
    1. Blundell J, De Graaf C, Hulshof T, Jebb S, Livingstone B, Lluch A, et al. Appetite control: methodological aspects of the evaluation of foods. Obes Rev. 2010;11:251–270.
    1. Jones, B, Kenward, M.Design and Analysis of Cross-Over Trials2nd edn. Chapman & Hall/CRC: New York, USA; 2003
    1. Bellisle F. Impact of the daily meal pattern on energy balance. Food Nutr Res. 2004;48:114–118.
    1. Reimer RR, McBurney MI. Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats. Endocrinology. 1996;137:3948–3956.
    1. Sleeth ML, Thompson EL, Ford HE, Zac-Varghese SEK, Frost G. Free fatty acid receptor 2 and nutrient sensing: a proposed role for fibre, fermentable carbohydrates and short-chain fatty acids in appetite regulation. Nutr Res Rev. 2010;23:135–145.
    1. Grover GJ, Koetzner L, Wicks J, Gahler RJ, Lyon MR, Reimer RA, et al. Effects of the soluble fiber complex PolyGlycopleX® (PGX®) on glycemic control, insulin secretion, and GLP-1 levels in Zucker diabetic rats. Life Sci. 2011;88:392–399.
    1. Reimer RA, Pelletier X, Carabin IG, Lyon M, Gahler R, Parnell JA, et al. Increased plasma PYY levels following supplementation with the functional fiber PolyGlycopleX in healthy adults. Eur J Clin Nutr. 2010;64:1186–1191.
    1. Le Roux CW, Batterham RL, Aylwin SJ, Patterson M, Borg CM, Wynne KJ, et al. Attenuated peptide PYY release in obese subjects is associated with reduced satiety. Endocrinology. 2006;147:3–8.
    1. Battherham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, et al. Inhibition of food intake in obese subjects by peptide YY3-36. New Engl J Med. 2003;349:941–948.
    1. Marciani L, Gowland PA, Spiller RC, Manoj P, Moore RJ, Young P, et al. Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI. Am J Physiol Gastrointest Liver Physiol. 2001;280:G1227–G1233.
    1. Maljaars PW, Peters HP, Mela DJ, Masclee AA. Ileal brake: a sensible food target for appetite control. A review. Physiol Behav. 2008;95:271–281.
    1. Van Citters GW, Lin HC. Ileal brake: neuropeptidergic control of intestinal transit. Curr Gastroenterol Rep. 2006;8:367–373.
    1. Jenkins DJ, Wolever TM, Taylor RH, Barker H, Fielden H, Baldwin JM, et al. Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr. 1981;34:362–366.
    1. Jenkins AL, Kacinik V, Lyon M, Wolever TM. Effect of adding the novel fiber, PGX®, to commonly consumed foods on glycemic response, glycemic index and GRIP: a simple and effective strategy for reducing post prandial blood glucose levels—a randomized, controlled trial. Nutr J. 2010;22:9:58.
    1. Brand-Miller JC, Atkinson FS, Gahler RJ, Kacinik V, Lyon MR, Wood S. Effects of PGX, a novel functional fibre, on acute and delayed postprandial glycemia. Eur J Clin Nutr. 2010;64:1488–1493.
    1. Arumugam V, Lee J-S, Nowal JK, Pohle RJ, Nyrop JE, Leddy J, et al. A high-glycemic meal pattern elicited increased subjective appetite sensations in overweight and obese women. Appetite. 2008;50:215–222.
    1. Dewan S, Gillett A, Mugarza JA, Dovey TM, Halford JC, Wilding JP. Effects of insulin-induced hypoglycemia on energy intake and food choices at a subsequent test meal. Diabetes Metab Res Rev. 2004;20:405–410.
    1. Holt S, Brand Miller JC, Petoccz P. Interrelationship among postprandial satiety, glucose, and insulin responses and changes in subsequent food intake. Eur J Clin Nutr. 1996;50:788–797.
    1. Anderson GH, Catherine NL, Woodend DM. Inverse association between the effect of carbohydrates on blood glucose and subsequent short-term food intake in young men. Am J Clin Nutr. 2002;76:1023–1030.
    1. Bornet FRJ, Jardy-Gennetier A-E, Jacquet N, Stowell J. Glycemic response to foods: impact on satiety and long-term weight regulation. Appetite. 2007;49:535–553.
    1. Flint A, Raben A, Blundell JE, Astrup A. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes. 2000;24:38–48.
    1. De Graaf C. The validity of appetite ratings. Appetite. 1993;21:156–160.
    1. De Castro J. Independence of genetic influences on body size, daily intake, and meal patterns in humans. Psychol Behav. 1993;54:633–639.
    1. Jéquier E, Tappy L. Regulation of body weight in humans. Psychol Rev. 1999;79:451–480.
    1. Herman CP, Ostovich JM, Polivy J. Effects of attentional focus on subjective hunger ratings. Appetite. 1999;33:181–193.
    1. Drewnowski A. Energy density, palatability, and satiety: implications for weight control. Nutr Rev. 1998;56:347–353.
    1. Rogers PJ, Schutz HG. Influence of palatability on subsequent hunger and food intake: a retrospective replication. Appetite. 1992;19:155–156.
    1. Womble LG, Wadden TA, Chandler JM, Martin AR. Agreement between weekly vs. daily assessment of appetite. Appetite. 2003;40:131–135.

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