Comparative effects of telmisartan in the treatment of hypertension

Abstract

Three separate randomized, double-blind, parallel-group, 12-week trials compared telmisartan with enalapril, lisinopril, and amlodipine for treating mild to moderate hypertension. Telmisartan 80 mg was associated with a significantly greater mean decrease in trough systolic and diastolic blood pressure than enalapril 20 mg (p<0.05). Mean decreases in trough systolic and diastolic blood pressure with telmisartan (40, 80, and 160 mg) and lisinopril (10, 20, and 40 mg) were similar. Telmisartan (40, 80, and 120 mg) provided greater decreases in mean hourly systolic and diastolic blood pressure throughout the 24-hour dosing interval, including the last 4 hours of the dosing period, than amlodipine (5 and 10 mg). Telmisartan was associated with a lower incidence of treatment-related cough than lisinopril and enalapril and less treatment-related angioedema than amlodipine. These data suggest that for treating mild to moderate hypertension, telmisartan has efficacy similar to lisinopril, greater efficacy than enalapril and amlodipine throughout the 24-hour dosing interval, and better tolerability than these angiotensin-converting enzyme inhibitors and amlodipine.

Copyright 2002 Le Jacq Communications, Inc.

Figures

Figure 1

Design of study comparing telmisartan and enalapri18 BP=blood pressure.

Figure 2

Adjusted mean changes from baseline in systolic blood pressure and diastolic blood pressure at week 12 for the telmisartan and enalapril groups. SBP/DBP=systolic/diastolic blood pressure; *p=0.001 vs. placebo; †p=0.01 vs. enalapril; ‡p=0.03 vs. enalapri18

Figure 3

Design of study comparing telmisartan and lisinopril. The placebo run‐in and dose escalation periods are shown.9

Figure 4

Design of study comparing telmisartan and amlodipine.10

Figure 5

Ambulatory blood pressure monitoring data for the telmisartan and amlodipine groups at week 12. A: Hourly mean systolic blood pressure. B: Hourly mean diastolic blood pressure SBP/DBP=systolic/diastolic blood pressure. Adapted with permission from Blood Press Monit. 1998;3:295–302.10