Microarray analysis in sperm from fertile and infertile men without basic sperm analysis abnormalities reveals a significantly different transcriptome
N Garrido, J A Martínez-Conejero, J Jauregui, J A Horcajadas, C Simón, J Remohí, M Meseguer, N Garrido, J A Martínez-Conejero, J Jauregui, J A Horcajadas, C Simón, J Remohí, M Meseguer
Abstract
Sperm analysis following World Health Organization guidelines is unable to explain the molecular causes of male infertility when basic sperm parameters are within a normal range and women do not present gynecologic pathology. Consequently, there is a need for accurate diagnostic tools in this area, and microarray technology emerges as promising. We present, for the first time, preliminary results of a comparison of sperm mRNA expression profiles between fertile and infertile men with normal semen parameters, discovering profound discrepancies between groups, with potential diagnostic and therapeutic possibilities.
Source: PubMed