Treatment of a non-healing diabetic foot ulcer with platelet-rich plasma

Deepak H Suresh, Shwetha Suryanarayan, Sacchidanand Sarvajnamurthy, Srikanth Puvvadi, Deepak H Suresh, Shwetha Suryanarayan, Sacchidanand Sarvajnamurthy, Srikanth Puvvadi

Abstract

Lower extremity ulcers and amputations are an increasing problem among individuals with diabetes. Among diabetes mellitus-related complications, foot ulceration is the most common, affecting approximately 15% of diabetic patients during their lifetime. The pathogenesis of diabetic ulcer is peripheral sensory neuropathy, calluses, oedema and peripheral vascular disease. Diabetic ulcer is managed by adequate control of infections and blood sugar levels, surgical debridement with various dressings and off loading of the foot from pressure. In spite of these standard measures, some recalcitrant non-healing ulcers need additional growth factors for healing. Autologous platelet-rich plasma is easy and cost-effective method in treating diabetic ulcers as it provides necessary growth factors which enhance healing.

Keywords: Diabetic ulcer; non-healing; platelet-rich plasma; post-amputation.

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
(a) The X-ray of left foot amputation. (b) The healed donor site of split thickness graft. (c) The non-healing diabetic foot ulcer
Figure 2
Figure 2
PRP injected to the ulcer
Figure 3
Figure 3
(a) The diabetic left foot ulcer before PRP. (b) After 1 sitting of PRP. (c) Ulcer after four sittings of PRP. (d) Ulcer healed completely at the end of 6 sittings
Figure 4
Figure 4
(a and b) The left foot (anterior and lateral view) after 8 weeks. (c) The MCR foot wear

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