Upfront thrombus aspiration in primary coronary intervention for patients with ST-segment elevation acute myocardial infarction: report of the VAMPIRE (VAcuuM asPIration thrombus REmoval) trial
Yuji Ikari, Masami Sakurada, Ken Kozuma, Shigeo Kawano, Takaaki Katsuki, Kazuo Kimura, Takahiko Suzuki, Takehiro Yamashita, Akinori Takizawa, Kazuo Misumi, Hideki Hashimoto, Takaaki Isshiki, VAMPIRE Investigators, Yuji Ikari, Masami Sakurada, Ken Kozuma, Shigeo Kawano, Takaaki Katsuki, Kazuo Kimura, Takahiko Suzuki, Takehiro Yamashita, Akinori Takizawa, Kazuo Misumi, Hideki Hashimoto, Takaaki Isshiki, VAMPIRE Investigators
Abstract
Objectives: This study evaluated safety and efficacy of upfront thrombus aspiration during primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI).
Background: Distal embolization during primary PCI results in reduced myocardial perfusion and poor clinical outcomes.
Methods: The VAMPIRE (VAcuuM asPIration thrombus REmoval) study was a prospective, randomized, controlled multicenter trial conducted in 23 institutions. Patients (N = 355) presenting within 24 h of STEMI symptoms onset were randomized to primary PCI with (n = 180) or without (n = 175) upfront thrombus aspiration using Nipro's TransVascular Aspiration Catheter (Osaka, Japan).
Results: The TransVascular Aspiration Catheter reached the lesion in 100% of cases. It successfully crossed the target obstruction in 86% without any delay in procedure time or time to reperfusion; whereas macroscopic thrombi were removed in 75% of the cases. Procedure success was similar between groups (98.9% vs. 98.3%). There was a trend toward lower incidence of slow or no reflow (primary end point-defined as a Thrombolysis In Myocardial Infarction flow grade <3) in patients treated with aspiration versus conventional primary PCI (12.4% vs. 19.4%, p = 0.07). Rate of myocardial blush grade 3 was higher in the aspiration group (46.0% vs. 20.5%, p < 0.001). Aspiration was most effective in patients presenting after 6 h of symptoms onset (slow flow rate: 8.1% vs. 37.6%, p = 0.01).
Conclusions: This study suggested the safety of primary PCI with upfront thrombectomy using a novel device in patients with STEMI. The study showed a trend toward improved myocardial perfusion and lower clinical events in patients treated with aspiration. Patients presenting late after STEMI appear to benefit the most from thrombectomy.
Source: PubMed