Correlation between symptoms and course duration of upper aerodigestive tract cancer at early and advanced stages

Francis Balduino Guimarães Santos, Jose Jacinto Branco Vasconcelos-Raposo, Maria do Carmo Tolentino Figueiredo, Francis Balduino Guimarães Santos, Jose Jacinto Branco Vasconcelos-Raposo, Maria do Carmo Tolentino Figueiredo

Abstract

There still are many clinical and biological aspects of the natural history of cancer of the upper aerodigestive tract to be unveiled; which in Brazil is a direct consequence of the failure of systematic prevention and early diagnosis campaigns.

Objective: To analyze the signs and symptoms presented by patients with the disease at initial and advanced stages. Other variables such as disease duration, general and nutritional status were considered.

Method: A historical cohort study with a cross-section involving 895 subjects with cancer of the upper aerodigestive tract.

Results: Clinical findings were not statistically correlated with disease progression, nor with the disease in early stages, but it showed rapid disease development.

Conclusion: The results suggest a disease of insidious onset in the early stages and fast course afterwards. The long disease duration - greater than three months, was associated with worsening in general and nutritional states of patients.

References

    1. Curado MP. S35 The Brazilian experience on mass screening. Oral Oncol Supp. 2007;2(1):123.
    1. Boyle P, Levin B. World Cancer Report 2008. World Health Organization; Lyon: 2009. pp. 13–15.
    1. Instituto Nacional do Câncer: Incidência de Câncer no Brasil: Estimativas 2012. [Acesso em 20 Dezembro de 2012]. Disponível em: .
    1. Barbosa MM. Diagnóstico e tratamento dos tumores de cabeça e pescoço. 1. Atheneu; São Paulo: 2001. pp. 491–495.
    1. Biazevic MGH, Castellanos RA, Antunes JLF, Michel-Crosato E. Tendências de mortalidade por câncer de boca e orofaringe no Município de São Paulo, Brasil, 1980/2002. Cad Saúde Pública. 2006;22(10):8–15.
    1. Santos RA, Portugal FB, Felix JD, Santos PMO, Siqueira MM. Avaliaçã o epidemiológica de pacientes com câncer no trato aerodigestivo superior: relevância dos fatores de risco álcool e tabaco. Rev Bras Cancerol. 2012;58(1):21–29.
    1. Avi ALRO, Tanimoto HM, Queiroz CDS, Gerim LR, Zuza EP, Trevisani DM, et al. Neoplasia de boca e orofaringe: um estudo transversal na Fundaçã o Pio XII - Hospital do Câncer de Barretos. Rev Odontol UNESP. 2012;41(4):273–280.
    1. Siu LL. Preface: head and neck cancer. Hematol Oncol Clin North Am. 2008;22(6):XIII–XIXV.
    1. Gervásio OL, Dutra RA, Tartaglia SM, Vasconcellos WA, Barbosa AA, Aguiar MC. Oral squamous cell carcinoma: a retrospective study of 740 cases in a Brazilian population. Braz Dent J. 2001;12(1):57–61.
    1. Onizawa K, Nishihara K, Yamagata K, Yusa H, Yanagawa T, Yoshida H. Factors associated with diagnostic delay of oral squamous cell carcinoma. Oral Oncol. 2003;39(8):781–788. doi: 10.1016/S1368-8375(03)000757. PMID: 13679201 DOI:
    1. Kowalski LP. Causes of diagnostic delay of oral cancer. Oral Oncol Supp. 2007;2(1):123.
    1. Tromp DM, Brouha XD, Hordijk GJ, Winnubst JA, de Leeuw RJ. Patient and tumour factors associated with advanced carcinomas of the head and neck. Oral Oncol. 2005;41(3):313–319. doi: 10.1016/j.oraloncology.2004.09.008. PMID: 15743694 DOI:
    1. Guidry JJ, Greisinger A, Aday LA, Winn RJ, Vernon S, Throckmorton TA. Barriers to cancer treatment: a review of published research. Oncol Nurs Forum. 1996;23(9):1393–1398. PMID: 8899755.
    1. Antunes JLF, Toporcov TN, Wünsch-Filho V. Resolutividade da campanha de prevençã o e diagnóstico precoce do câncer bucal em São Paulo, Brasil. Rev Panam Salud Pública. 2007;21(1):30–36. doi: 10.1590/S1020-49892007000100004. DOI:
    1. Franco EL, Kowalski LP, Oliveira BV, Curado MP, Pereira RN, Silva ME, et al. Risk factors for oral cancer in Brazil: a case-control study. Int J Cancer. 1989;43(6):992–1000. doi: 10.1002/ijc.2910430607. PMID: 2732011 DOI:
    1. Noce CW, Rebelo MS. Avaliaçã o da relaçã o entre tamanho do tumor e características sociais em pacientes com carcinoma de células escamosas bucal. Rev Bras Cancerol. 2008;54(2):123–129.
    1. Jitomirski F. In: Saúde bucal coletiva. 4. Pinto VG, editor. Editora Santos; São Paulo: 2000. Câncer bucal; pp. 445–456.
    1. Koivunen P, Rantala N, Hyrynkangas K, Jokinen K, Alho OP. The impact of patient and professional diagnostic delays on survival in pharyngeal cancer. Cancer. 2001;92(11):2885–2891. doi: 10.1002/1097-0142(20011201)92:11%202885::AID-CNCR10119%;2-G. PMID: 11753962 DOI:
    1. Morelatto RA, Herrera MC, Fernández EN, Corball AG, López de Blanc SA. Diagnostic delay of oral squamous cell carcinoma in two diagnosis centers in Córdoba Argentina. J Oral Pathol Med. 2007;36:405–408. doi: 10.1111/j.1600-0714.2007.00547.X. PMID: 17617833 DOI:
    1. Teixeira CM. O consumo de bebidas alcoólicas como lazer [Tese de doutorado] Universidade de Trás-os-Montes Alto Douro; Vila Real: 2008.
    1. Ramos C, Carvalho JEC, Mangiacavalli MASC. Impacto e (i) mobilizaçã o: um estudo sobre campanhas de prevençã o ao câncer. Ciênc Saúde Coletiva. 2007;12(5):1387–1396. doi: 10.1590/S1413-81232007000500036. DOI:
    1. Sankaranarayanan R, Masuyer E, Swaminathan R, Ferlay J, Whelan S. Head and neck cancer: a global perspective on epidemiology and prognosis. Anticancer Res. 1998;18(6B):4779–4786. PMID: 9891557.
    1. Sciubba JJ. Improving detection of precancerous and cancerous oral lesions. Computer-assisted analysis of the oral brush biopsy. U.S. Collaborative OralCDx Study Group. J Am Dent Assoc. 1999;130(10):1445–1457.
    1. Myers EN. Otorrinolaringologia cirúrgica - Cirurgia de cabeça e pescoço. 2a. Dilivros; Rio de Janeiro: 2011. pp. 305–332.
    1. Franceschi S, Bidoli E, Herrero R, Muñoz N. Comparison of cancers of the oral cavity and pharynx worldwide: etiological clues. Oral Oncol. 2000;36(1):106–115. doi: 10.1016/S1368-8375(99)000706. DOI:
    1. Dhooge IJ, Albers FW, van Cauwenberge PB. Clinical characteristics and diagnostic delay of head and neck cancer: results from a prospective study in Belgium. Eur J Surg Oncol. 1996;22(4):354–358. doi: 10.1016/S0748-7983(96)902206. PMID: 8783651 DOI:
    1. Fritz A, Percy C, Jack A, Shanmugaratnam K, Sobin LH, Parkin MD, editors. International classification of diseases for oncology (ICD-O) 3rd. World Health Organization; Geneva: 2000.
    1. Sobin LH, Wittekind Ch. Classification of Malignant Tumours. 6. John Wiley & Sons; New Jersey: 2004. pp. 1–44.
    1. Detsky AS, McLaughlin JR, Baker JP, Johnston N, Whittaker S, Mendelson RA, et al. What is subjective global assessment of nutritional status? JPEN J Parenter Enteral Nutr. 1987;11(1):8–13. doi: 10.1177/014860718701100108. PMID: 3820522 DOI:
    1. Detsky AS, Smalley PS, Chang J. The rational clinical examination. Is this patient malnourished? JAMA. 1994;271(1):54–58. doi: 10.1001/jama.1994.03510250070038. PMID: 8258889 DOI:
    1. Ecog/WHO . Eastern Cooperative Oncology Group/World Health Organization. WHO; 2008.
    1. Hashibe M, Brennan P, Benhamou S, Castellsague X, Chen C, Curado MP, et al. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst. 2007;99(10):777–789. doi: 10.1093/jnci/djk179. PMID: 17505073 DOI:
    1. Wünsch-Filho V. The epidemiology of oral and pharynx cancer in Brazil. Oral Oncol. 2002;38(8):737–746. doi: 10.1016/S1368-8375(02)000660. PMID: 12570051 DOI:
    1. Abdo EN, Garrocho AA, Aguiar MCF. Perfil do paciente portador de carcinoma epidermóide da cavidade bucal, em tratamento no Hospital Mário Penna em Belo Horizonte. Rev Bras Cancerol. 2002;48(3):357–362.
    1. Gouvea AS, Nogueira MX, Oliveira ZFL, Podestá JRV, Zeidler SVV. Aspectos clínicos e epidemiológicos do câncer bucal em um hospital oncológico: predomínio de doença localmente avançada. Rev Bras Cir Cabeça Pescoço. 2010;39(4):261–265.
    1. Farah CS, Ford PJ, Allen K, Vu A, McCullough MJ. Oral Cancer and Potentially Cancerous Lesions - Early Detection and Diagnosis. Oral Cancer. 2012 Disponível em.
    1. IARC - International Agency for Research on Cancer: 2009. Oral cancer/First evidence from a randomized trial that screening reduces oral cancer mortality: The trivandrum oral cancer screening study (TOCS). Kerala, India. [Acesso em: 2011] Disponível em:
    1. IARC . International Agency for Research on Cancer: Cervix Cancer Screening. IARC Working Group; Lyon: 2005. pp. 59–201.
    1. Bispo dos Santos AL, Marinho RC, Lima PNM, Fortes RC. Avaliaçã o nutricional subjetiva proposta pelo paciente versus outros métodos de avaliaçã o do estado nutricional em pacientes oncológicos. Rev Bras Nutr Clín. 2012;27(4):243–249.
    1. Cuffari L, Tesseroli de Siqueira JT, Nemr K, Rapaport A. Pain complaint as the first symptom of oral cancer: a descriptive study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102(1):56–61. doi: 10.1016/j.tripleo.2005.10.041. PMID: 16831673 DOI:
    1. Abdo EN, Garrocho Ade A, Barbosa AA, Oliveira EL, Franca-Filho L, Negri SL, et al. Time elapsed between the first symptoms, diagnosis and treatment of oral cancer patients in Belo Horizonte, Brazil. Med Oral Patol Oral Cir Bucal. 2007;12(7):469–473.
    1. Campos JLG, Chagas JFS, Magna LA. Fatores de atraso no diagnóstico do câncer de cabeça e pescoço e sua relaçã o com sobrevida e qualidade de vida. Rev Bras Cir Cabeça Pescoço. 2007;36(2):65–68.

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