Hospitalization rates before and after adult-to-adult living donor or deceased donor liver transplantation
Robert M Merion, Tempie H Shearon, Carl L Berg, James E Everhart, Michael M Abecassis, Abraham Shaked, Robert A Fisher, James F Trotter, Robert S Brown Jr, Norah A Terrault, Paul H Hayashi, Johnny C Hong, A2ALL Study Group, Jean C Emond, Robert S Brown Jr, Rudina Odeh-Ramadan, Scott Heese, Michael M I Abecassis, Laura M Kulik, Patrice Al-Saden, Abraham Shaked, Kim M Olthoff, Brian Conboy, Mary Shaw, Gregory T Everson, Igal Kam, Carlos Garcia, Anastasia Krajec, Johnny C Hong, Ronald W Busuttil, Janet Mooney, Chris E Freise, Norah A Terrault, Dulce MacLeod, Vivian Tan, Robert M Merion, Tempie H Shearon, Carl L Berg, James E Everhart, Michael M Abecassis, Abraham Shaked, Robert A Fisher, James F Trotter, Robert S Brown Jr, Norah A Terrault, Paul H Hayashi, Johnny C Hong, A2ALL Study Group, Jean C Emond, Robert S Brown Jr, Rudina Odeh-Ramadan, Scott Heese, Michael M I Abecassis, Laura M Kulik, Patrice Al-Saden, Abraham Shaked, Kim M Olthoff, Brian Conboy, Mary Shaw, Gregory T Everson, Igal Kam, Carlos Garcia, Anastasia Krajec, Johnny C Hong, Ronald W Busuttil, Janet Mooney, Chris E Freise, Norah A Terrault, Dulce MacLeod, Vivian Tan
Abstract
Objective: To compare rates of hospitalization before and after adult-to-adult living donor liver transplant (LDLT) and deceased donor liver transplant (DDLT).
Summary background data: LDLT recipients have been reported to have lower mortality but a higher complication rate than DDLT recipients. The higher complication rate may be associated with greater consumption of inpatient hospital resources and a higher burden of disease for LDLT recipients.
Methods: Data from the 9-center Adult-to-Adult Living Donor Liver Transplantation retrospective cohort study were analyzed to determine pretransplant, transplant, and posttransplant hospitalizations among LDLT candidates (potential living donor was evaluated) who received LDLT or DDLT. Hospital days and admission rates for LDLT and DDLT patients were calculated per patient-year at risk, starting from the date of initial potential donor history and physical examination. Rates were compared using overdispersed Poisson regression models.
Results: Among 806 candidates, 384 received LDLT and 215 received DDLT. In addition to the 599 transplants, there were 1913 recipient hospitalizations (485 pretransplant; 1428 posttransplant). Mean DDLT recipient pretransplant, transplant, and posttransplant lengths of stay were 5.8 +/- 6.3, 27.0 +/- 32.6, and 9.0 +/- 14.1 days, respectively, and for LDLT were 4.1 +/- 3.7, 21.4 +/- 24.3, and 7.8 +/- 11.4 days, respectively. Compared with DDLT, LDLT recipients had significantly lower adjusted pretransplant hospital day and admission rates, but significantly higher posttransplant rates. Significantly higher LDLT admission rates were observed for biliary tract morbidity throughout the second posttransplant year. Overall hospitalization rates starting from the point of potential donor evaluation were significantly higher for eventual recipients of LDLT.
Conclusions: LDLT recipients, despite lower acuity of disease, have higher hospitalization requirements when compared with DDLT recipients. Continuing efforts are warranted to reduce the incidence of complications requiring post-LDLT inpatient admission, with particular emphasis on biliary tract issues.
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Source: PubMed