CKD is a key risk factor for COVID-19 mortality
Ron T Gansevoort, Luuk B Hilbrands, Ron T Gansevoort, Luuk B Hilbrands
Abstract
A new study uses the OpenSAFELY health analytics platform to identify risk factors for COVID-19 mortality. This analysis, which includes data for more than 17 million people in the UK, suggests that patients with chronic kidney disease are at higher risk than those with other known risk factors, including chronic heart and lung disease.
Conflict of interest statement
The authors declare no competing interests.
Figures
Estimated hazard ratios (HRs) from a multivariable model. Error bars represent 95% confidence intervals. All HRs are adjusted for all other factors. Well-controlled diabetes is defined as HbA1c
References
- Huang C, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. doi: 10.1016/S0140-6736(20)30183-5.
- Guan WJ, et al. Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. Eur. Respir. J. 2020;55:2000547. doi: 10.1183/13993003.00547-2020.
- Grasselli G, et al. Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy. JAMA Intern. Med. 2020 doi: 10.1001/jamainternmed.2020.
- Docherty AB, et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. Br. Med. J. 2020;369:m1985. doi: 10.1136/bmj.m1985.
- Kim L, et al. Risk factors for intensive care unit admission and in-hospital mortality among hospitalized adults identified through the U.S. Coronavirus Disease 2019 (COVID-19)-associated Hospitalization Surveillance Network (COVID-NET) Clin. Infect. Dis. 2020 doi: 10.1093/cid/ciaa1012.
- Williamson EJ, et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature. 2020;584:430–436. doi: 10.1038/s41586-020-2521-4.
- Sudharsanan N, Didzun O, Bärnighausen T, Geldsetzer P. The contribution of the age distribution of cases to COVID-19 case fatality across countries: a 9-country demographic study. Ann. Intern. Med. 2020 doi: 10.7326/M20-2973.
- Li X, et al. Impact of cardiovascular disease and cardiac injury on in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis. Heart. 2020 doi: 10.1136/heartjnl-2020-317062.
- Noordzij M, et al. ERACODA: the European database collecting information of patients on kidney replacement therapy with COVID-19. Nephrol. Dial. Transplant. 2020 doi: 10.1093/ndt/gfaa179/5891689.
Source: PubMed