Short communication: factors influencing time to CD4(+) T cell counts >200 cells/mm(3) in HIV-infected individuals with CD4(+) T cell Nam Su Ku  1 , Young Goo Song, Sang Hoon Han, Sun Bean Kim, Hye-won Kim, Su Jin Jeong, Chang Oh Kim, June Myung Kim, Jun Yong Choi Affiliations Expand Affiliation 1 Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea. PMID: 22632127 PMCID: PMC3505051 DOI: 10.1089/AID.2011.0282 Free PMC article Item in Clipboard

Abstract

We evaluated factors influencing time to CD4(+) T cell counts >200 cells/mm(3) in HIV-infected individuals with CD4(+) T cell <50 cells/mm(3) starting combination antiretroviral therapy (cART). We included a total of 29 patients on successful cART for more than 1 year. In a logistic regression model, higher pre-cART CD4(+) T cell counts were significantly associated with shorter time to CD4(+) T cell counts >200cells/mm(3) in HIV-infected individuals with baseline CD4(+) T cell <50 cells/mm(3). In survival analysis, patients having higher pre-cART CD4(+) T cell counts, especially 40-49 cells/mm(3), were at significantly higher risk of achieving CD4(+) T cell counts >200 cells/mm(3).