Prevalence and Clinical Features of Atopic Dermatitis in China

Xin Wang, Lin-Feng Li, Da-Yu Zhao, Yi-Wei Shen, Xin Wang, Lin-Feng Li, Da-Yu Zhao, Yi-Wei Shen

Abstract

Background. The epidemiology of atopic dermatitis (AD) in Chinese outpatients is yet to be clarified. Objectives. To investigate population-based prevalence and clinical features of AD in Chinese outpatients. Methods. A multicenter cross-sectional study was conducted in outpatients with eczema or dermatitis from 39 tertiary hospitals in 15 provinces. Results. This study included 682 patients diagnosed with AD, with the mean age of 28.8 ± 20.1 years and the median course of 5.3 ± 6.9 years. AD patients had more severe itching (30.4% versus 13.8%, p < 0.001) and clinically suspected bacterial infection (21.7% versus 16.1%, p < 0.001) than those of other types of dermatitis. Older patients were more susceptible to have a history of flexion dermatitis (p < 0.001), bacterial infection (p = 0.005), and severe itching (p < 0.001). Outpatients with clinically suspected bacterial infection had 3.53-fold increased risk of AD than those without it (p < 0.001). The morbidity rate of AD in the (20-25°N) region is 2.86 times higher than that in the (40-45°N) region [OR (95% CI): 0.352 (0.241-0.514), p < 0.001]. Conclusions. AD is characterized by unique clinical/demographic features. Bacterial infection and latitude region may have an impact on the incidence of AD in China.

Conflict of interest statement

The authors declare that there is no conflict of interests regarding the publication of this paper.

Figures

Figure 1
Figure 1
Lesions distribution of AD and other types of dermatitis. ∗This body location was more involved in AD than other types of dermatitis, p < 0.05, Chi-square test. #This body location was more involved in other types of dermatitis than AD, p < 0.05, Chi-square test.
Figure 2
Figure 2
Skin lesion types of AD and other types of dermatitis. ∗This skin lesion type was more common in AD than other types of dermatitis, p < 0.05, Chi-square test.

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