Percutaneous implantation of autologous bone marrow osteoprogenitor cells as treatment of bone avascular necrosis related to sickle cell disease

Philippe Hernigou, Gilsasio Daltro, Paolo Filippini, Martin Mukisi Mukasa, Olivier Manicom, Philippe Hernigou, Gilsasio Daltro, Paolo Filippini, Martin Mukisi Mukasa, Olivier Manicom

Abstract

The treatment of bone a vascular necrosis is a big challenge considering the youthfulness of the patients involved by necrosis in sickle cell disease and the importance of the generated disability. A vascular osteonecrosis is an epiphysis pathology which could be treated by joint replacement with success, however, multiple surgical procedures are mostly necessary during the patient's life with a hazardous long term functional results. The treatment by autologous bone marrow grafting is an effective alternative which preserve the native joint. Using this mini-invasive high technology surgical treatment in early stages, a joint replacement could be avoided in many patients.

Keywords: Avascular osteonecrosis; bone regeneration.; marrow grafting; mesenchymal stem cell.

Figures

Fig. (1)
Fig. (1)
Comparison of the natural evolution of hip osteonecrosis with the evolution after percutaneous implantation of bone marrow.

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