The modified checklist for autism in toddlers: a follow-up study investigating the early detection of autism spectrum disorders
Jamie M Kleinman, Diana L Robins, Pamela E Ventola, Juhi Pandey, Hilary C Boorstein, Emma L Esser, Leandra B Wilson, Michael A Rosenthal, Saasha Sutera, Alyssa D Verbalis, Marianne Barton, Sarah Hodgson, James Green, Thyde Dumont-Mathieu, Fred Volkmar, Katarzyna Chawarska, Ami Klin, Deborah Fein, Jamie M Kleinman, Diana L Robins, Pamela E Ventola, Juhi Pandey, Hilary C Boorstein, Emma L Esser, Leandra B Wilson, Michael A Rosenthal, Saasha Sutera, Alyssa D Verbalis, Marianne Barton, Sarah Hodgson, James Green, Thyde Dumont-Mathieu, Fred Volkmar, Katarzyna Chawarska, Ami Klin, Deborah Fein
Abstract
Autism spectrum disorders (ASD) often go undetected in toddlers. The Modified Checklist for Autism in Toddlers (M-CHAT) was used to screen 3,793 children aged 16-30 months from low- and high-risk sources; screen positive cases were diagnostically evaluated. Rescreening was performed on 1,416 children aged 42-54 months. Time 1 Positive Predictive Value (PPV) was .36 for the initial screening and .74 for the screening plus follow-up telephone interview; values were similar for Time2 PPV. When separating referral sources, PPV was low for the low-risk sample but acceptable with the followup telephone interview. Children with ASD from the low-risk and high-risk samples were highly similar. Results indicate that the M-CHAT continues to be a promising instrument for the early detection of ASD.
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Source: PubMed