Cross-reactive Antibody Response to mRNA SARS-CoV-2 Vaccine After Recent COVID-19-Specific Monoclonal Antibody Therapy
Stacey Schultz-Cherry, Maureen A McGargill, Paul G Thomas, Jeremie H Estepp, Aditya H Gaur, E Kaitlynn Allen, Kim J Allison, Li Tang, Richard J Webby, Sean D Cherry, Chun-Yang Lin, Thomas Fabrizio, Elaine I Tuomanen, Joshua Wolf, SJTRC Investigative Team, Ericka Kirkpatrick Roubidoux, Pamela Freiden, Tomi Mori, Diego R Hijano, Hana Hakim, David C Brice, Ashley Castellaw, Florian Krammer, David E Wittman, Jason Hodges, Ronald H Dallas, Valerie Cortez, Ana Vazquez-Pagan, Resha Bajracharya, Brandi L Clark, Lee-Ann Van de Velde, Walid Awad, Taylor L Wilson, Allison M Kirk, Randall T Hayden, James Hoffman, Jamie Russell-Bell, James Sparks, Stacey Schultz-Cherry, Maureen A McGargill, Paul G Thomas, Jeremie H Estepp, Aditya H Gaur, E Kaitlynn Allen, Kim J Allison, Li Tang, Richard J Webby, Sean D Cherry, Chun-Yang Lin, Thomas Fabrizio, Elaine I Tuomanen, Joshua Wolf, SJTRC Investigative Team, Ericka Kirkpatrick Roubidoux, Pamela Freiden, Tomi Mori, Diego R Hijano, Hana Hakim, David C Brice, Ashley Castellaw, Florian Krammer, David E Wittman, Jason Hodges, Ronald H Dallas, Valerie Cortez, Ana Vazquez-Pagan, Resha Bajracharya, Brandi L Clark, Lee-Ann Van de Velde, Walid Awad, Taylor L Wilson, Allison M Kirk, Randall T Hayden, James Hoffman, Jamie Russell-Bell, James Sparks
Abstract
The efficacy of coronavirus disease 2019 (COVID-19) vaccines administered after COVID-19-specific monoclonal antibody is unknown, and "antibody interference" might hinder immune responses leading to vaccine failure. In an institutional review board-approved prospective study, we found that an individual who received mRNA COVID-19 vaccination <40 days after COVID-19-specific monoclonal antibody therapy for symptomatic COVID-19 had similar postvaccine antibody responses to SARS-CoV-2 receptor binding domain (RBD) for 4 important SARS-CoV-2 variants (B.1, B.1.1.7, B.1.351, and P.1) as other participants who were also vaccinated following COVID-19. Vaccination against COVID-19 shortly after COVID-19-specific monoclonal antibody can boost and expand antibody protection, questioning the need to delay vaccination in this setting.
Trial registration: The St. Jude Tracking of Viral and Host Factors Associated with COVID-19 study; NCT04362995; https://ichgcp.net/clinical-trials-registry/NCT04362995.
Keywords: COVID-19; SARS-CoV-2; antibody; bamlanivimab; vaccine failure.
© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
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Source: PubMed