Molecular surveillance for multidrug-resistant Plasmodium falciparum, Cambodia

Naman K Shah, Alisa P Alker, Rithy Sem, Agustina Ika Susanti, Sinuon Muth, Jason D Maguire, Socheat Duong, Frederic Ariey, Steven R Meshnick, Chansuda Wongsrichanalai, Naman K Shah, Alisa P Alker, Rithy Sem, Agustina Ika Susanti, Sinuon Muth, Jason D Maguire, Socheat Duong, Frederic Ariey, Steven R Meshnick, Chansuda Wongsrichanalai

Abstract

We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.

Figures

Figure 1
Figure 1
Map of Cambodia with locations of surveillance sites and proportion of isolates containing 1, 2, or >3 copies of pfmdr1, May 2004–December 2006.
Figure 2
Figure 2
Median values and interquartile ranges of pfmdr1 copy number across 5 surveillance sites in Cambodia, May 2004–December 2006. Kg., Kampong.

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