Prevalence and correlates of inadequate glycaemic control: results from a nationwide survey in 6,671 adults with diabetes in Brazil

Ana Beatriz Valverde Mendes, João Antônio Saraiva Fittipaldi, Raimundo Celestino Silva Neves, Antônio Roberto Chacra, Edson Duarte Moreira Jr, Ana Beatriz Valverde Mendes, João Antônio Saraiva Fittipaldi, Raimundo Celestino Silva Neves, Antônio Roberto Chacra, Edson Duarte Moreira Jr

Abstract

Diabetes is a significant public health burden on the basis of its increased incidence, morbidity, and mortality. This study aimed to estimate the prevalence of inadequate glycaemic control and its correlates in a large multicentre survey of Brazilian patients with diabetes. A cross-sectional study was conducted in a consecutive sample of patients aged 18 years or older with either type 1 or type 2 diabetes, attending health centres located in ten large cities in Brazil (response rate = 84%). Information about diabetes, current medications, complications, diet, and satisfaction with treatment were obtained by trained interviewers, using a standardized questionnaire. Glycated haemoglobin (HbA(1c)) was measured by high-performance liquid chromatography in a central laboratory. Patients with HbA(1c) > or = 7 were considered to have inadequate glycaemic control. Overall 6,701 patients were surveyed, 979 (15%) with type 1 and 5,692 (85%) with type 2 diabetes. The prevalence of inadequate glycaemic control was 76%. Poor glycaemic control was more common in patients with type 1 diabetes (90%) than in those with type 2 (73%), P < 0.001. Characteristics significantly associated with improved glycaemic control included: fewer years of diabetes duration, multi professional care, participation in a diabetes health education program, and satisfaction with current diabetes treatment. Despite increased awareness of the benefits of tight glycaemic control, we found that few diabetic patients in Brazil met recommended glycaemic control targets. This may contribute to increased rates of diabetic complications, which may impact health care costs. Our data support the public health message of implementation of early, aggressive management of diabetes.

Figures

Fig. 1
Fig. 1
Relationship between self-reported global satisfaction with diabetes treatment and distribution of HbA1c values, according to diabetes type, Brazil, 2006

References

    1. Narayan KM, Gregg EW, Fagot-Campagna A, Engelgau MM, Vinicor F. Diabetes—a common, growing, serious, costly, and potentially preventable public health problem. Diabetes Res Clin Pract. 2000;50(Suppl 2):S77–S84. doi: 10.1016/S0168-8227(00)00183-2.
    1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047–1053. doi: 10.2337/diacare.27.5.1047.
    1. Yach D, Stuckler D, Brownell KD. Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. Nat Med. 2006;12:62–66. doi: 10.1038/nm0106-62.
    1. Park JS, Cho MH, Nam JS, Ahn CW, Cha BS, Lee EJ et al (2009) Visceral adiposity and leptin are independently associated with C-reactive protein in Korean type 2 diabetic patients. Acta Diabetol. doi:10.1007/s00592-009-0125-4
    1. Deepa R, Pradeepa R, Shanthirani CS, Mohan V. Association of hypertension with cluster of insulin resistance syndrome factors: the Chennai Urban Population Study (CUPS-12) Acta Diabetol. 2004;41:49–55. doi: 10.1007/s00592-004-0144-0.
    1. Raman R, Rani PK, Gnanamoorthy P, Sudhir RR, Kumaramanikavel G, Sharma T (2009) Association of obesity with diabetic retinopathy: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study (SN-DREAMS Report no. 8). Acta Diabetol. doi:10.1007/s00592-009-0113-8
    1. No Authors (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 329:977–86
    1. No Authors (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352:837–53
    1. American Association of Clinical Endocrinologists (2002) American College of Endocrinology consensus statement on guidelines for glycemic control. Endocr Pract 8:5–11
    1. Ahmad Khan H. Clinical significance of HbA1c as a marker of circulating lipids in male and female type 2 diabetic patients. Acta Diabetol. 2007;44:193–200. doi: 10.1007/s00592-007-0003-x.
    1. Ben Abdelaziz A, Soltane I, Gaha K, Thabet H, Tlili H, Ghannem H. Predictive factors of glycemic control in patients with type 2 diabetes mellitus in primary health care. Rev Epidemiol Sante Publique. 2006;54:443–452. doi: 10.1016/S0398-7620(06)76742-6.
    1. Fox KM, Gerber Pharmd RA, Bolinder B, Chen J, Kumar S. Prevalence of inadequate glycemic control among patients with type 2 diabetes in the United Kingdom general practice research database: a series of retrospective analyses of data from 1998 through 2002. Clin Ther. 2006;28:388–395. doi: 10.1016/j.clinthera.2006.03.005.
    1. Harris SB, Ekoe JM, Zdanowicz Y, Webster-Bogaert S. Glycemic control and morbidity in the Canadian primary care setting (results of the diabetes in Canada evaluation study) Diabetes Res Clin Pract. 2005;70:90–97. doi: 10.1016/j.diabres.2005.03.024.
    1. Jorgensen LG, Petersen PH, Heickendorff L, Moller HJ, Hendel J, Christensen C, et al. Glycemic control in diabetes in three Danish counties. Clin Chem Lab Med. 2005;43:1366–1372. doi: 10.1515/CCLM.2005.233.
    1. Koro CE, Bowlin SJ, Bourgeois N, Fedder DO. Glycemic control from 1988 to 2000 among U.S. adults diagnosed with type 2 diabetes: a preliminary report. Diabetes Care. 2004;27:17–20. doi: 10.2337/diacare.27.1.17.
    1. Leinung MC, Gianoukakis AG, Lee DW, Jeronis SL, Desemone J. Comparison of diabetes care provided by an endocrinology clinic and a primary-care clinic. Endocr Pract. 2000;6:361–366.
    1. Otieno CF, Kariuki M, Ng’ang’a L. Quality of glycaemic control in ambulatory diabetics at the out-patient clinic of Kenyatta National Hospital, Nairobi. East Afr Med J. 2003;80:406–410.
    1. Pittrow D, Stalla GK, Zeiher AM, Silber S, Marz W, Pieper L, et al. Prevalence, drug treatment and metabolic control of diabetes mellitus in primary care. Med Klin (Munich) 2006;101:635–644. doi: 10.1007/s00063-006-1093-x.
    1. Saydah SH, Fradkin J, Cowie CC. Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. JAMA. 2004;291:335–342. doi: 10.1001/jama.291.3.335.
    1. Shah BR, Hux JE, Laupacis A, Mdcm BZ, Austin PC, van Walraven C. Diabetic patients with prior specialist care have better glycaemic control than those with prior primary care. J Eval Clin Pract. 2005;11:568–575. doi: 10.1111/j.1365-2753.2005.00582.x.
    1. Tutuncuoglu P, Sarac F, Saygili F, Ozgen AG, Yilmaz C, Tuzun M. Diabetes and impaired glucose tolerance prevalences in Turkish patients with impaired fasting glucose. Acta Diabetol. 2008;45:151–156. doi: 10.1007/s00592-008-0034-y.
    1. Malerbi DA, Franco LJ. Multicenter study of the prevalence of diabetes mellitus and impaired glucose tolerance in the urban Brazilian population aged 30–69 yr. The Brazilian Cooperative Group on the Study of Diabetes Prevalence. Diabetes Care. 1992;15:1509–1516. doi: 10.2337/diacare.15.11.1509.
    1. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370:1453–1457. doi: 10.1016/S0140-6736(07)61602-X.
    1. American Diabetes Association (2003) Standards of medical care for patients with diabetes mellitus. Diabetes Care 26(Suppl 1):S33–50
    1. Hoerger TJ, Segel JE, Gregg EW, Saaddine JB. Is glycemic control improving in U.S. adults? Diabetes Care. 2008;31:81–86. doi: 10.2337/dc07-1572.
    1. Goudswaard AN, Stolk RP, Zuithoff P, Rutten GE. Patient characteristics do not predict poor glycaemic control in type 2 diabetes patients treated in primary care. Eur J Epidemiol. 2004;19:541–545. doi: 10.1023/B:EJEP.0000032351.42772.e7.
    1. Hawthorne K, Tomlinson S. Pakistani moslems with Type 2 diabetes mellitus: effect of sex, literacy skills, known diabetic complications and place of care on diabetic knowledge, reported self-monitoring management and glycaemic control. Diabet Med. 1999;16:591–597. doi: 10.1046/j.1464-5491.1999.00102.x.
    1. Salcedo-Rocha AL, Garcia de Alba-Garcia JE, Frayre-Torres MJ, Lopez-Coutino B. Gender and metabolic control of type 2 diabetes among primary care patients. Rev Med Inst Mex Seguro Soc. 2008;46:73–81.
    1. Tabak AG, Tamas G, Zgibor J, Wilson R, Becker D, Kerenyi Z, et al. Targets and reality: a comparison of health care indicators in the U.S. (Pittsburgh Epidemiology of Diabetes Complications Study) and Hungary (DiabCare Hungary) Diabetes Care. 2000;23:1284–1289. doi: 10.2337/diacare.23.9.1284.
    1. Zgibor JC, Songer TJ, Kelsey SF, Weissfeld J, Drash AL, Becker D, et al. The association of diabetes specialist care with health care practices and glycemic control in patients with type 1 diabetes: a cross-sectional analysis from the Pittsburgh epidemiology of diabetes complications study. Diabetes Care. 2000;23:472–476. doi: 10.2337/diacare.23.4.472.
    1. Cavanaugh K, Huizinga MM, Wallston KA, Gebretsadik T, Shintani A, Davis D, et al. Association of numeracy and diabetes control. Ann Intern Med. 2008;148:737–746.
    1. Roblin DW, Ntekop E, Becker ER. Improved intermediate clinical outcomes from participation in a diabetes health education program. J Ambul Care Manag. 2007;30:64–73.
    1. Ishii H, Anderson JH, Jr, Yamamura A, Takeuchi M, Ikeda I. Improvement of glycemic control and quality-of-life by insulin lispro therapy: assessing benefits by ITR-QOL questionnaires. Diabetes Res Clin Pract. 2008;81:169–178. doi: 10.1016/j.diabres.2008.03.020.
    1. Chisalita SI, Lindstrom T, Eson Jennersjo P, Paulsson JF, Westermark GT, Olsson AG, et al. Differential lipid profile and hormonal response in type 2 diabetes by exogenous insulin aspart versus the insulin secretagogue repaglinide, at the same glycemic control. Acta Diabetol. 2009;46:35–42. doi: 10.1007/s00592-008-0055-6.
    1. Rosenstock J, Cappelleri JC, Bolinder B, Gerber RA. Patient satisfaction and glycemic control after 1 year with inhaled insulin (Exubera) in patients with type 1 or type 2 diabetes. Diabetes Care. 2004;27:1318–1323. doi: 10.2337/diacare.27.6.1318.
    1. De Mattia G, Laurenti O, Moretti A. Comparison of glycaemic control in patients with type 2 diabetes on basal insulin and fixed combination oral antidiabetic treatment: results of a pilot study. Acta Diabetol. 2009;46:67–73. doi: 10.1007/s00592-008-0078-z.

Source: PubMed

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