The effectiveness of self-care and lifestyle interventions in primary dysmenorrhea: a systematic review and meta-analysis

Mike Armour, Caroline A Smith, Kylie A Steel, Freya Macmillan, Mike Armour, Caroline A Smith, Kylie A Steel, Freya Macmillan

Abstract

Background: Menstrual pain is very common amongst young women. Despite the significant impact that menstrual pain has on academic attendance and performance, social activities and quality of life, most young women do not seek medical treatment but prefer to use self-care; commonly OTC analgesic medications and rest. Many women do not get significant pain relief from these methods, therefore other low cost, easy to learn self-care methods may be a valuable approach to management. This review and meta-analysis examines the evidence for participant lead self-care techniques.

Methods: A search of Medline, PsychINFO, Google Scholar and CINAHL was carried out in September 2017.

Results: Twenty-three trials including 2302 women were eligible and included in the meta-analysis. Studies examined self-delivered acupressure, exercise and heat as interventions. Risk of bias was unclear for many domains. All interventions showed a reduction in menstrual pain symptoms; exercise (g = 2.16, 95% CI 0.97 to 3.35) showed the largest effect size, with heat (g = 0.73, 95% CI 0.06 to 1.40) and acupressure (g = 0.56, 95% CI 0.10 to 1.03) showing more moderate effect sizes. Exercise (g = 0.48, 95% CI 0.12 to 0.83) and heat (g = 0.48, 95% CI 0.10 to 0.87), were more effective than analgesics in reducing pain intensity, whereas acupressure was significantly less effective (g = - 0.76, 95% CI -1.37 to - 0.15).

Conclusion: Exercise showed large effects, while acupressure and heat showed moderate effects in reducing menstrual pain compared to no treatment. Both exercise and heat are potential alternatives to analgesic medication. However, difficulties in controlling for non-specific effects, along with potential for bias, may influence study findings.

Keywords: Acupressure; Exercise; Heat; Period pain; Self-care.

Conflict of interest statement

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

MA and CS: As a medical research institute, National Institute of Complementary Medicine (NICM) receives research grants and donations from foundations, universities, government agencies and industry. Sponsors and donors provide untied and tied funding for work to advance the vision and mission of the Institute. This systematic review was not specifically supported by donor or sponsor funding to NICM.

KS: none known.

FM: none known.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram
Fig. 2
Fig. 2
Summary of risk of bias across studies
Fig. 3
Fig. 3
Risk of bias for individual studies
Fig. 4
Fig. 4
Pooled effects of acupressure, exercise and heat on overall menstrual pain
Fig. 5
Fig. 5
Comparison of the effect of acupressure or heat versus analgesic medication on menstrual pain intensity
Fig. 6
Fig. 6
Comparison of acupressure vs sham acupressure on menstrual pain intensity
Fig. 7
Fig. 7
Comparison of acupressure or exercise versus no treatment/usual care on menstrual pain intensity

References

    1. French L. Dysmenorrhea in adolescents: diagnosis and treatment. Paediatr. Drugs. 2008;10(1):1–7. doi: 10.2165/00148581-200810010-00001.
    1. Parker MA, Sneddon AE, Arbon P. The menstrual disorder of teenagers (MDOT) study: determining typical menstrual patterns and menstrual disturbance in a large population-based study of Australian teenagers. BJOG. 2010;117(2):185–192. doi: 10.1111/j.1471-0528.2009.02407.x.
    1. Subasinghe AK, Happo L, Jayasinghe YL, Garland SM, Gorelik A, Wark JD. Prevalence and severity of dysmenorrhoea, and management options reported by young Australian women. Aust Fam Physician. 2016;45(11):829–834.
    1. Wong CL, Farquhar C, Roberts H, Proctor M. Oral contraceptive pill for primary dysmenorrhoea. Cochrane Database Syst Rev. 2009;4:CD002120.
    1. Proctor M, Farquhar C. Diagnosis and management of dysmenorrhoea. BMJ. 2006;332(7550):1134–1138. doi: 10.1136/bmj.332.7550.1134.
    1. Dawood MY. Primary dysmenorrhea: advances in pathogenesis and management. Obstet Gynecol. 2006;108(2):428–441. doi: 10.1097/01.AOG.0000230214.26638.0c.
    1. Zahradnik HP, Hanjalic-Beck A, Groth K. Nonsteroidal anti-inflammatory drugs and hormonal contraceptives for pain relief from dysmenorrhea: a review. Contraception. 2010;81(3):185–196. doi: 10.1016/j.contraception.2009.09.014.
    1. Campbell MA, McGrath PJ. Use of medication by adolescents for the management of menstrual discomfort. Arch Pediatr Adolesc Med. 1997;151(9):905–913. doi: 10.1001/archpedi.1997.02170460043007.
    1. Hillen TI, Grbavac SL, Johnston PJ, Straton JA, Keogh JM. Primary dysmenorrhea in young Western Australian women: prevalence, impact, and knowledge of treatment. J Adolesc Health. 1999;25(1):40–45. doi: 10.1016/S1054-139X(98)00147-5.
    1. Burnett MA, Antao V, Black A, Feldman K, Grenville A, Lea R, Lefebvre G, Pinsonneault O, Robert M. Prevalence of primary dysmenorrhea in Canada. J Obstet Gynaecol Can. 2005;27(8):765–770. doi: 10.1016/S1701-2163(16)30728-9.
    1. Banikarim C, Chacko MR, Kelder SH. Prevalence and impact of dysmenorrhea on Hispanic female adolescents. Arch Pediatr Adolesc Med. 2000;154(12):1226–1229. doi: 10.1001/archpedi.154.12.1226.
    1. Baker FC, Driver HS, Rogers GG, Paiker J, Mitchell D. High nocturnal body temperatures and disturbed sleep in women with primary dysmenorrhea. Am J Phys. 1999;277(6 Pt 1):E1013–E1021.
    1. Lefebvre G, Pinsonneault O, Antao V, Black A, Burnett M, Feldman K, Lea R, Robert M. SOGC: primary dysmenorrhea consensus guideline. J Obstet Gynaecol Can. 2005;27(12):1117–1146. doi: 10.1016/S1701-2163(16)30395-4.
    1. Marjoribanks J, Proctor M, Farquhar C, Derks RS. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. Cochrane Database Syst Rev. 2010;1:CD001751.
    1. Harel Z. Dysmenorrhea in adolescents and young adults: from pathophysiology to pharmacological treatments and management strategies. Expert Opin Pharmacother. 2008;9(15):2661–2672. doi: 10.1517/14656566.9.15.2661.
    1. Coco AS. Primary dysmenorrhea. Am Fam Physician. 1999;60(2):489–496.
    1. Dawood MY. Dysmenorrhea. Clin Obstet Gynecol. 1990;33(1):168–178. doi: 10.1097/00003081-199003000-00023.
    1. Howard F, Perry P, Carter J, El-Minawi A. Pelvic pain: diagnosis and management. Philadelphia: Lippincott Williams and Wilkins; 2000.
    1. Zhu X, Wong F, Bensoussan A, Lo SK, Zhou C, Yu J. Are there any cross-ethnic differences in menstrual profiles? A pilot comparative study on australian and chinese women with primary dysmenorrhea. J Obstet Gynaecol Res. 2010;36(5):1093–1101. doi: 10.1111/j.1447-0756.2010.01250.x.
    1. Ortiz MI, Rangel-Flores E, Carrillo-Alarcon LC, Veras-Godoy HA. Prevalence and impact of primary dysmenorrhea among Mexican high school students. Int J Gynaecol Obstet. 2009;107(3):240–243. doi: 10.1016/j.ijgo.2009.07.031.
    1. Johnson J. Level of knowledge among adolescent girls regarding effective treatment for dysmenorrhea. J Adolesc Health Care. 1988;9(5):398–402. doi: 10.1016/0197-0070(88)90036-8.
    1. Klein JR, Litt IF. Epidemiology of adolescent dysmenorrhea. Pediatrics. 1981;68(5):661–664.
    1. Chang SF, Chuang MH. Factors that affect self-care behaviour of female high school students with dysmenorrhoea: a cluster sampling study. Int J Nurs Pract. 2012;18(2):117–124. doi: 10.1111/j.1440-172X.2012.02007.x.
    1. Wong LP. Attitudes towards dysmenorrhoea, impact and treatment seeking among adolescent girls: a rural school-based survey. Aust J Rural Health. 2011;19(4):218–223. doi: 10.1111/j.1440-1584.2011.01213.x.
    1. Wong LP, Khoo EM. Dysmenorrhea in a multiethnic population of adolescent asian girls. Int J Gynaecol Obstet. 2010;108(2):139–142. doi: 10.1016/j.ijgo.2009.09.018.
    1. Ortiz MI, Fernandez-Martinez E, Perez-Hernandez N, Macias A, Rangel-Flores E, Ponce-Monter H. Patterns of prescription and self-medication for treating primary dysmenorrhea in a Mexican population. Proc West Pharmacol Soc. 2007;50:165–167.
    1. Chia CF, Lai JH, Cheung PK, Kwong LT, Lau FP, Leung KH, Leung MT, Wong FC, Ngu SF. Dysmenorrhoea among Hong Kong university students: prevalence, impact, and management. Hong Kong Med J. 2013;19(3):222–228.
    1. MacKichan F, Paterson C, Henley WE, Britten N. Self-care in people with long term health problems: a community based survey. BMC Fam Pract. 2011;12:53. doi: 10.1186/1471-2296-12-53.
    1. Ryan A, Wilson S, Taylor A, Greenfield S. Factors associated with self-care activities among adults in the United Kingdom: a systematic review. BMC Public Health. 2009;9:96. doi: 10.1186/1471-2458-9-96.
    1. Cheng H-F, Lin Y-H. Selection and efficacy of self-management strategies for dysmenorrhea in young Taiwanese women. J Clin Nurs. 2011;20(7–8):1018–1025. doi: 10.1111/j.1365-2702.2010.03363.x.
    1. Wong CL, Ip WY, Lam LW. Self-care strategies among Chinese adolescent girls with dysmenorrhea: a qualitative study. Pain Manag Nurs. 2016;17(4):262–271. doi: 10.1016/j.pmn.2016.04.001.
    1. Chen C-H, Lin Y-H, Heitkemper MM, Wu K-M. The self-care strategies of girls with primary dysmenorrhea: a focus group study in Taiwan. Health Care Women Int. 2006;27(5):418–427. doi: 10.1080/07399330600629583.
    1. Armour M, Dahlen HG, Smith CA. More than needles: the importance of explanations and self-care advice in treating primary dysmenorrhea with acupuncture. Evid Based Complement Alternat Med. 2016;2016:3467067. doi: 10.1155/2016/3467067.
    1. Pattanittum P, Kunyanone N, Brown J, Sangkomkamhang US, Barnes J, Seyfoddin V, Marjoribanks J. Dietary supplements for dysmenorrhoea. Cochrane Database Syst Rev. 2016;3:Cd002124.
    1. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009;62(10):1006–1012. doi: 10.1016/j.jclinepi.2009.06.005.
    1. Smith CA, Levett KM, Collins CT, Armour M, Dahlen HG, Suganuma M. Relaxation techniques for pain management in labour. Cochrane Database Syst Rev. 2018;3:CD009514.
    1. Smith CA, Armour M, Zhu X, Li X, Lu ZY, Song J. Acupuncture for dysmenorrhoea. Cochrane Database Syst Rev. 2016;4:CD007854.
    1. Pescatello LS, American College of Sports M . ACSM’s guidelines for exercise testing and prescription. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins Health; 2014.
    1. Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JA, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. doi: 10.1136/bmj.d5928.
    1. Hedges L, Olkin I. Statistical methods for meta-analysis. San Diego: Academic Press; 1985.
    1. Cohen J. Statistical power analysis for the behavioral sciences. Routledge Academic: New York; 1988.
    1. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–1101. doi: 10.2307/2533446.
    1. Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. Bmj. 1997;315(7109):629–634. doi: 10.1136/bmj.315.7109.629.
    1. Duval S, Tweedie R. Trim and fill: a simple funnel-plot–based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56(2):455–463. doi: 10.1111/j.0006-341X.2000.00455.x.
    1. Orwin RG. A fail-safe N for effect size in meta-analysis. J Educ Stat. 1983;8(2):157–159.
    1. Akin M, Price W, Rodriguez G, Erasala G, Hurley G, Smith RP. Continuous, low-level, topical heat wrap therapy as compared to acetaminophen for primary dysmenorrhea. J Reprod Med. 2004;49(9):739–745.
    1. Akin MD, Weingand KW, Hengehold DA, Goodale MB, Hinkle RT, Smith RP. Continuous low-level topical heat in the treatment of dysmenorrhea. Obstet Gynecol. 2001;97(3):343–349.
    1. Potur DC, Komurcu N. The effects of local low-dose heat application on dysmenorrhea. J Pediatr Adolesc Gynecol. 2014;27(4):216–221. doi: 10.1016/j.jpag.2013.11.003.
    1. Navvabi Rigi S, Kermansaravi F, Navidian A, Safabakhsh L, Safarzadeh A, Khazaian S, Shafie S, Salehian T. Comparing the analgesic effect of heat patch containing iron chip and ibuprofen for primary dysmenorrhea: a randomized controlled trial. BMC Womens Health. 2012;12:25. doi: 10.1186/1472-6874-12-25.
    1. Aghamiri ZB, Vigeh M, Latifnezhead R, Nabavi S. Study of effect of acupressure methods on pain in primary dysmenorrhea. Hayat. 2005;11(4):19–28.
    1. Behbahani BM, Ansaripour L, Akbarzadeh M, Zare N, Hadianfard MJ. Comparison of the effects of acupressure and self-care behaviors training on the intensity of primary dysmenorrhea based on McGill pain questionnaire among Shiraz University students. J Res Med Sci. 2016;21:104. doi: 10.4103/1735-1995.193176.
    1. Bazarganipour F, Lamyian M, Heshmat R, Abadi MA, Taghavi A. A randomized clinical trial of the efficacy of applying a simple acupressure protocol to the Taichong point in relieving dysmenorrhea. Int J Gynaecol Obstet. 2010;111(2):105–109. doi: 10.1016/j.ijgo.2010.04.030.
    1. Charandabi SM, Nashtaei MS, Kamali S, Majlesi R. The effect of acupressure at the Sanyinjiao point (SP6) on primary dysmenorrhea in students resident in dormitories of Tabriz. Iran J Nurs Midwifery Res. 2011;16(4):309–317.
    1. Chen H-M, Chen C-H. Effects of acupressure on menstrual distress in adolescent girls: a comparison between Hegu-Sanyinjiao matched points and Hegu, Zusanli single point. J Clin Nurs. 2010;19(7–8):998–1007. doi: 10.1111/j.1365-2702.2009.02872.x.
    1. Chen HM, Wang HH, Chiu MH, Hu HM. Effects of acupressure on menstrual distress and low back pain in dysmenorrheic young adult women: an experimental study. Pain Manag Nurs. 2015;16(3):188–197. doi: 10.1016/j.pmn.2014.06.002.
    1. Kashefi F, Ziyadlou S, Khajehei M, Ashraf AR, Fadaee AR, Jafari P. Effect of acupressure at the Sanyinjiao point on primary dysmenorrhea: a randomized controlled trial. Complement Ther Clin Pract. 2010;16(4):198–202. doi: 10.1016/j.ctcp.2010.04.003.
    1. Mirbagher-Ajorpaz N, Adib-Hajbaghery M, Mosaebi F. The effects of acupressure on primary dysmenorrhea: a randomized controlled trial. Complement Ther Clin Pract. 2011;17(1):33–36. doi: 10.1016/j.ctcp.2010.06.005.
    1. Pouresmail Z, Ibrahimzadeh R. Effects of acupressure and ibuprofen on the severity of primary dysmenorrhea. J Tradit Chin Med. 2002;22(3):205–210.
    1. Wang MC, Hsu MC, Chien LW, Kao CH, Liu CF. Effects of auricular acupressure on menstrual symptoms and nitric oxide for women with primary dysmenorrhea. J Altern Complement Med. 2009;15(3):235–242. doi: 10.1089/acm.2008.0164.
    1. Yeh ML, Hung YL, Chen HH, Wang YJ. Auricular acupressure for pain relief in adolescents with dysmenorrhea: a placebo-controlled study. J Altern Complement Med. 2013;19(4):313–318. doi: 10.1089/acm.2011.0665.
    1. Zafari MTM, Aghamohammady A, Behmanesh F, Rakhshaee Z. Comparison of the effect of acupressure, fish oil capsules and ibuprofen on treatment of primary dysmenorrheal. Afr J Pharm Pharmacol. 2011;5(8):1115–1119.
    1. Chen HM, Chen CY. Effects of acupressure at the Sanyinjiao point on primary dysmenorrhoea. J Adv Nurs. 2004;48(4):380. doi: 10.1111/j.1365-2648.2004.03236.x.
    1. Wong CL, Lai KY, Tse HM. Effects of SP6 acupressure on pain and menstrual distress in young women with dysmenorrhea. Complement Ther Clin Pract. 2010;16(2):64–69. doi: 10.1016/j.ctcp.2009.10.002.
    1. Abbaspour Z, Rostami M, Najjar S. The effect of exercise on primary dysmenorrhea. J Res Health Sci. 2006;6(1):26–31.
    1. Motahari-Tabari N, Shirvani MA, Alipour A. Comparison of the effect of stretching exercises and Mefenamic acid on the reduction of pain and menstruation characteristics in primary dysmenorrhea: a randomized clinical trial. Oman Med J. 2017;32(1):47–53. doi: 10.5001/omj.2017.09.
    1. Rakhshaee Z. Effect of three yoga poses (cobra, cat and fish poses) in women with primary dysmenorrhea: a randomized clinical trial. J Pediatr Adolesc Gynecol. 2011;24(4):192–196. doi: 10.1016/j.jpag.2011.01.059.
    1. Shahr-jerdy S, Hosseini RS, Gh ME. Effects of stretching exercises on primary dysmenorrhea in adolescent girls. Biomedical Human Kinetics. 2012;4:127–32.
    1. Yang NY, Kim SD. Effects of a yoga program on menstrual cramps and menstrual distress in undergraduate students with primary dysmenorrhea: a single-blind, randomized controlled trial. J Altern Complement Med. 2016;22(9):732–738. doi: 10.1089/acm.2016.0058.
    1. Andersch B, Milsom I. An epidemiologic study of young women with dysmenorrhea. Am J Obstet Gynecol. 1982;144(6):655–660. doi: 10.1016/0002-9378(82)90433-1.
    1. Yeh ML, Hung YL, Chen HH, Lin JG, Wang YJ. Auricular acupressure combined with an internet-based intervention or alone for primary dysmenorrhea: a control study. Evid Based Complement Alternat Med. 2013;2013:316212.
    1. O'Connell K, Davis AR, Westhoff C. Self-treatment patterns among adolescent girls with dysmenorrhea. J Pediatr Adolesc Gynecol. 2006;19(4):285–289. doi: 10.1016/j.jpag.2006.05.004.
    1. Blakey H, Chisholm C, Dear F, Harris B, Hartwell R, Daley AJ, Jolly K. Is exercise associated with primary dysmenorrhoea in young women? BJOG. 2010;117(2):222–224. doi: 10.1111/j.1471-0528.2009.02220.x.
    1. Vani KR, K SV. L S. VRH K, A B Menstrual abnormalities in school going girls - are they related to dietary and exercise pattern? J Clin Diagn Res. 2013;7(11):2537–2540.
    1. Metheny WP, Smith RP. The relationship among exercise, stress, and primary dysmenorrhea. J Behav Med. 1989;12(6):569–586. doi: 10.1007/BF00844826.
    1. Hightower M. Effects of exercise participation on menstrual pain and symptoms. Women & Health. 1998;26(4):15–27. doi: 10.1300/J013v26n04_02.
    1. Govindaraj R, Karmani S, Varambally S, Gangadhar BN. Yoga and physical exercise – a review and comparison. Int Rev Psychiatry. 2016;28(3):242–253. doi: 10.3109/09540261.2016.1160878.
    1. Daley AJ. Exercise and primary dysmenorrhoea : a comprehensive and critical review of the literature. Sports Med. 2008;38(8):659–670. doi: 10.2165/00007256-200838080-00004.
    1. Febbraio MA. Exercise and inflammation. J Appl Physiol (1985) 2007;103(1):376–377. doi: 10.1152/japplphysiol.00414.2007.
    1. Warren MP, Perlroth NE. The effects of intense exercise on the female reproductive system. J Endocrinol. 2001;170(0022–0795 (Print)):3–11. doi: 10.1677/joe.0.1700003.
    1. Pascoe MC, Thompson DR, Ski CF. Yoga, mindfulness-based stress reduction and stress-related physiological measures: A meta-analysis. Psychoneuroendocrinology. 2017;86(1873–3360 (Electronic)):152–168. doi: 10.1016/j.psyneuen.2017.08.008.
    1. Casey ML, MacDonald PC, Mitchell MD. Despite a massive increase in cortisol secretion in women during parturition, there is an equally massive increase in prostaglandin synthesis. A paradox? J Clin Invest. 1985;75(6):1852–1857. doi: 10.1172/JCI111899.
    1. Bertone-Johnson ER, Ronnenberg AG, Houghton SC, Nobles C, Zagarins SE, Takashima-Uebelhoer BB, Faraj JL, Whitcomb BW. Association of inflammation markers with menstrual symptom severity and premenstrual syndrome in young women. Hum Reprod. 2014;29(9):1987–1994. doi: 10.1093/humrep/deu170.
    1. Gold EB, Wells C, MON R. The Association of Inflammation with Premenstrual Symptoms. J Womens Health (Larchmt) 2016;25(9):865–874. doi: 10.1089/jwh.2015.5529.
    1. Tsai S-Y. Effect of yoga exercise on premenstrual symptoms among female employees in Taiwan. Int J Environ Res Public Health. 2016;13(7):721. doi: 10.3390/ijerph13070721.
    1. Kuntz A. Anatomic and physiologic properties of cutaneous-visceral vasomotor reflex arcs. J Neurophysiol. 1945;8:421–429. doi: 10.1152/jn.1945.8.6.421.
    1. Otte JW, Merrick MA, Ingersoll CD, Cordova ML. Subcutaneous adipose tissue thickness alters cooling time during cryotherapy. Arch Phys Med Rehabil. 2002;83(11):1501–1505. doi: 10.1053/apmr.2002.34833.
    1. Armour M, Smith CA. Treating primary dysmenorrhoea with acupuncture: a narrative review of the relationship between acupuncture ‘dose’ and menstrual pain outcomes. Acupunct Med. 2016;34(6):416–424. doi: 10.1136/acupmed-2016-011110.
    1. Cho S-H, Hwang E-W. Acupressure for primary dysmenorrhoea: a systematic review. Complement Ther Med. 2010;18(1):49–56. doi: 10.1016/j.ctim.2009.10.001.
    1. Chen YW, Wang HH. The effectiveness of acupressure on relieving pain: a systematic review. Pain Manag Nurs. 2014;15(2):539–550. doi: 10.1016/j.pmn.2012.12.005.
    1. Paterson C, Baarts C, Launsø L, Verhoef MJ. Evaluating complex health interventions: a critical analysis of the ‘outcomes’ concept. BMC Complement Altern Med. 2009;9:18. doi: 10.1186/1472-6882-9-18.
    1. Grandi G, Ferrari S, Xholli A, Cannoletta M, Palma F, Romani C, Volpe A, Cagnacci A. Prevalence of menstrual pain in young women: what is dysmenorrhea? J Pain Res. 2012;5:169–174. doi: 10.2147/JPR.S30602.
    1. Ghaderi F, Asghari Jafarabadi M, Mohseni Bandpei MA. Dysmenorrhea and self-care strategies in Iranian female students: a regression modeling of pain severity and underlying factors. Int J Adolesc Med Health. 2016;29(6). 10.1515/ijamh-2016-0017.
    1. Potur DC, Bilgin NC, Komurcu N. Prevalence of dysmenorrhea in university students in Turkey: effect on daily activities and evaluation of different pain management methods. Pain Manag Nurs. 2014;15(4):768–777. doi: 10.1016/j.pmn.2013.07.012.
    1. Latthe P, Mignini L, Gray R, Hills R, Khan K. Factors predisposing women to chronic pelvic pain: systematic review. Bmj. 2006;332(7544):749–755. doi: 10.1136/bmj.38748.697465.55.
    1. Cramer H, Ward L, Saper R, Fishbein D, Dobos G, Lauche R. The safety of yoga: a systematic review and meta-analysis of randomized controlled trials. Am J Epidemiol. 2015;182(4):281–293. doi: 10.1093/aje/kwv071.
    1. Tan J-Y, Suen LK, Wang T, Molassiotis A. Sham acupressure controls used in randomized controlled trials: a systematic review and critique. PLoS One. 2015;10(7):e0132989. doi: 10.1371/journal.pone.0132989.

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