Functional serotonin 5-HTTLPR polymorphism is a risk factor for migraine with aura
Barbara Borroni, Cristina Brambilla, Paolo Liberini, Renata Rao, Silvana Archetti, Stefano Gipponi, Giorgio Dalla Volta, Alessandro Padovani, Barbara Borroni, Cristina Brambilla, Paolo Liberini, Renata Rao, Silvana Archetti, Stefano Gipponi, Giorgio Dalla Volta, Alessandro Padovani
Abstract
In the present work, we report that the functional serotonin transporter gene promoter (5-HTTLPR) polymorphism is involved in migraine pathogenesis. The distribution of 5-HTTLPR genotypes was significantly different in MA patients (S/S vs. S/L vs. L/L=32.7 vs. 42.3 vs. 25.0%), MO patients (18.5 vs. 39.1 vs. 42.4%) and CON (18.0 vs. 51.3 vs. 30.7%; chi-square test, p<0.05). In 5-HTTLPR S/S carriers, the odds ratio for MA risk was 2.60 (95% confidence interval [95%CI]=1.75-3.85) compared to CON, and it was 2.14 (95%CI=1.42-3.21) compared to MO. These data provide a further insight on the complex genotype-phenotype relationship involved in MA pathogenesis, and might eventually result in new and individualised prognostic and therapeutic measures.
Source: PubMed