Effect of Insulin Degludec Versus Insulin Glargine U100 on Hypoglycemia in Hispanic Patients With Type 2 Diabetes: Results From the SWITCH 2 Trial

Louis Chaykin, Anuj Bhargava, Raymond de la Rosa, Carol H Wysham, Lone Nørgård Troelsen, Signe H Østoft, Athena Philis-Tsimikas, Louis Chaykin, Anuj Bhargava, Raymond de la Rosa, Carol H Wysham, Lone Nørgård Troelsen, Signe H Østoft, Athena Philis-Tsimikas

Abstract

IN BRIEF Hispanic patients with type 2 diabetes have poorer glycemic control and are at higher risk of severe diabetes complications and mortality than non-Hispanic white patients. This post hoc analysis investigated the safety and efficacy of insulin degludec versus insulin glargine 100 units/mL (glargine U100) in the Hispanic patient subpopulation from the SWITCH 2 trial. In Hispanic patients, hypoglycemia was consistently lower and nocturnal hypoglycemia was significantly lower with degludec versus glargine U100 at similar levels of glycemic control. Overall, results in Hispanic patients in SWITCH 2 were consistent with those in non-Hispanic patients.

Figures

FIGURE 1.
FIGURE 1.
ERRs (degludec/glargine U100) of hypoglycemia in Hispanic and non-Hispanic patients during the SWITCH 2 trial. Full analysis set. *Only four episodes of severe hypoglycemia were reported in the maintenance period, which precluded statistical analysis. P values derived using a Poisson Model with logarithm of the exposure time (100 years) as offset; estimates adjusted for treatment, period, sequence, and dosing time as fixed effects and patient as random effects. BG, blood glucose.
FIGURE 2.
FIGURE 2.
Glycemic control in Hispanic and non-Hispanic patients during the SWITCH 2 trial. Full analysis set. A and B: A1C. C and D: FPG. Estimated treatment differences (ETDs; degludec – glargine U100) for change in A1C after 32 weeks of treatment are derived from a mixed model for repeated measures with an unstructured covariance matrix including sex, antidiabetic therapy at screening, visit and dosing time as fixed effects, and age and baseline A1C as covariates. FPG, fasting plasma glucose.

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Source: PubMed

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