First Case of 2019 Novel Coronavirus in the United States

Michelle L Holshue, Chas DeBolt, Scott Lindquist, Kathy H Lofy, John Wiesman, Hollianne Bruce, Christopher Spitters, Keith Ericson, Sara Wilkerson, Ahmet Tural, George Diaz, Amanda Cohn, LeAnne Fox, Anita Patel, Susan I Gerber, Lindsay Kim, Suxiang Tong, Xiaoyan Lu, Steve Lindstrom, Mark A Pallansch, William C Weldon, Holly M Biggs, Timothy M Uyeki, Satish K Pillai, Washington State 2019-nCoV Case Investigation Team, Cynthia Harry, Mike Boysun, Jasmine Matheson, Denny Russell, Brian Hiatt, Sara Podczervinski, Larissa Lewis, Patricia Montgomery, Wayne Turnberg, Nicholas R Graff, Tia K H Dostal, Esther W Lam, Mary Chan, Vivian Hawkins, Matt Zimmerman, Kevin Wickersham, Xinyao deGrauw, Kim Peifer, Elyse Bevers, Tessa Fairfortune, Claire M Midgley, Stephanie Kujawski, Eileen Schneider, John T Watson, Jennifer Hunter, Marie E Killerby, Brian Rha, Sara Oliver, Melissa Rolfes, Aron Hall, Alicia Fry, Dan Jernigan, Victoria Chu, Hannah Kirking, Krista Queen, Ying Tao, Yan Li, Clinton R Paden, Jing Zhang, Michelle L Holshue, Chas DeBolt, Scott Lindquist, Kathy H Lofy, John Wiesman, Hollianne Bruce, Christopher Spitters, Keith Ericson, Sara Wilkerson, Ahmet Tural, George Diaz, Amanda Cohn, LeAnne Fox, Anita Patel, Susan I Gerber, Lindsay Kim, Suxiang Tong, Xiaoyan Lu, Steve Lindstrom, Mark A Pallansch, William C Weldon, Holly M Biggs, Timothy M Uyeki, Satish K Pillai, Washington State 2019-nCoV Case Investigation Team, Cynthia Harry, Mike Boysun, Jasmine Matheson, Denny Russell, Brian Hiatt, Sara Podczervinski, Larissa Lewis, Patricia Montgomery, Wayne Turnberg, Nicholas R Graff, Tia K H Dostal, Esther W Lam, Mary Chan, Vivian Hawkins, Matt Zimmerman, Kevin Wickersham, Xinyao deGrauw, Kim Peifer, Elyse Bevers, Tessa Fairfortune, Claire M Midgley, Stephanie Kujawski, Eileen Schneider, John T Watson, Jennifer Hunter, Marie E Killerby, Brian Rha, Sara Oliver, Melissa Rolfes, Aron Hall, Alicia Fry, Dan Jernigan, Victoria Chu, Hannah Kirking, Krista Queen, Ying Tao, Yan Li, Clinton R Paden, Jing Zhang

Abstract

An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases now confirmed in multiple countries. We report the first case of 2019-nCoV infection confirmed in the United States and describe the identification, diagnosis, clinical course, and management of the case, including the patient's initial mild symptoms at presentation with progression to pneumonia on day 9 of illness. This case highlights the importance of close coordination between clinicians and public health authorities at the local, state, and federal levels, as well as the need for rapid dissemination of clinical information related to the care of patients with this emerging infection.

Figures

Figure 1. Posteroanterior and Lateral Chest Radiographs,… — **Figure 1. Posteroanterior and Lateral Chest Radiographs, January 19, 2020 (Illness Day 4).**
No thoracic abnormalities were noted.

Figure 2. Symptoms and Maximum Body Temperatures… — **Figure 2. Symptoms and Maximum Body Temperatures According to Day of Illness and Day of Hospitalization, January 16 to January 30, 2020.**

Figure 3. Posteroanterior and Lateral Chest Radiographs,… — **Figure 3. Posteroanterior and Lateral Chest Radiographs, January 22, 2020 (Illness Day 7, Hospital Day 3).**
No acute intrathoracic plain-film abnormality was noted.

Figure 4. Posteroanterior Chest Radiograph, January 24,… — **Figure 4. Posteroanterior Chest Radiograph, January 24, 2020 (Illness Day 9, Hospital Day 5).**
Increasing left basilar opacity was visible, arousing concern about pneumonia.

Figure 5. Anteroposterior and Lateral Chest Radiographs,… — **Figure 5. Anteroposterior and Lateral Chest Radiographs, January 26, 2020 (Illness Day 10, Hospital Day 6).**
Stable streaky opacities in the lung bases were visible, indicating likely atypical pneumonia; the opacities have steadily increased in density over time.

References

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Source: PubMed

First Case of 2019 Novel Coronavirus in the United States

Abstract

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References

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