Early childhood growth and cognitive outcomes: Findings from the MAL-ED study

Abstract

Although many studies around the world hope to measure or improve developmental progress in children to promote community flourishing and productivity, growth is sometimes used as a surrogate because cognitive skills are more difficult to measure. Our objective was to assess how childhood measures of anthropometry correlate with measures of child development in low-income settings with high prevalence of poor nutrition and enteric disease, to inform studies considering growth outcomes in the absence of direct child developmental skill assessment. Children from the MAL-ED study were followed from birth to 24 months of age in field sites in 8 low- and middle-income countries across 3 continents. Monthly weight, length, and head circumference measurements were performed. At 24 months, the Bayley Scales of Infant and Toddler Development was administered. We correlated cognitive measures at 24 months with anthropometric measurements from birth to 2 years comparing 3 constructs: absolute attained monthly measures, summative difference in measures from the mean growth curve, and rate of change in measures. Growth faltering at multiple time periods is related to Bayley cognitive outcomes at 24 months. Birthweight, overall growth by 18-24 months, and rate of growth in the 6- to 18-month period were most associated with 24-month developmental scores. In this study, head circumference measurements, compared with length, was more closely linked to cognitive scores at 24 months. Notably, all studies between growth and cognitive outcomes exhibited low r2 values (0.001-0.049). Anthropometric measures, particularly head circumference, were related to cognitive development, although explaining a low percent of variance. When feasible, direct measures of child development may be more useful.

Keywords: cognition; early childhood development; global health; growth; malnutrition; stunting.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

© 2018 John Wiley & Sons Ltd.

Figures

Figure 1

Mean 24‐month Bayley cognitive score by category of enrolment weight z‐score (adjusted by site). Overall model linear trend test p = 0.02

Figure 2

Associations between attained growth z‐scores from 1 to 24 months of age with Bayley Cognitive Score at 24 months of age. Mean difference (95% confidence interval) in cognitive score at 24 months associated with an increase in attained growth z‐score by 1 at each month (analysed in separate regressions) from 1 to 24. (a) Weight‐for‐age z‐score (WAZ). (b) Length‐for‐age z‐score (LAZ). (c) Head‐circumference‐for‐age z‐score (HCZ). Regressions are adjusted for research site and enrolment weight

Figure 3

Mean difference (95% confidence interval) in cognitive score at 24 months associated with an increase in summative growth z‐score by 1 for 6‐month intervals between 0 and 24 months. (a) Weight‐for‐age z‐score (WAZ). (b) Length‐for‐age z‐score (LAZ). (c) Head‐circumference‐for‐age z‐score (HCZ)

Figure 4

Mean difference (95% confidence interval) in cognitive score at 24 months associated with an increase in growth rate z‐score by 1 for 6‐month intervals between 0 and 24 months. (a) Weight‐for‐age z‐score (WAZ); (b) Length‐for‐age z‐score (LAZ); (c) Head‐circumference‐for‐age z‐score (HCZ)