Internet interventions: Past, present and future

Gerhard Andersson, Gerhard Andersson

Abstract

Internet interventions have been around now for about 20 years. While the field still suffers from a scattered terminology a large number of programs and studies exist. In the present paper I present an overview of my experiences of studying internet-supported cognitive-behaviour therapy (ICBT), but also mention other approaches including the use of smartphones. The paper covers the history of ICBT, short-term effects in controlled trials for a range of conditions, long-term effects, comparisons against face-to-face therapy, effectiveness studies, prediction studies, how the treatment is perceived, critique, and finally future directions. I conclude that we have now reached a stage in which we have numerous evidence-based treatments and procedures, and increasingly internet interventions including ICBT are disseminated.

Keywords: Anxiety; Internet treatment; Mood disorders; Somatic disorders; Therapist guidance.

References

    1. Andersson E., Enander J., Andrén P., Hedman E., Ljótsson B., Hursti T., Bergström J., Kaldo V., Lindefors N., Andersson G., Rück C. Internet-based cognitive behaviour therapy for obsessive-compulsive disorder: a randomised controlled trial. Psychol. Med. 2012;42:2193–2203.
    1. Andersson E., Hedman E., Wadström O., Boberg J., Andersson E.Y., Axelsson E., Bjureberg J., Hursti T., Ljotsson B. Internet-based extinction therapy for worry: a randomized controlled trial. Behav. Ther. 2017;48:391–402.
    1. Andersson E., Rück C., Lavebratt C., Hedman E., Schalling M., Lindefors N., Eriksson E., Carlbring P., Andersson G., Furmark T. Genetic polymorphisms in monoamine systems and outcome of cognitive behavior therapy for social anxiety disorder. PLoS One. 2013;8
    1. Andersson E., Walén C., Hallberg J., Paxling B., Dahlin M., Almlöv J., Källström R., Wijma K., Carlbring P., Andersson G. A randomized controlled trial of guided Internet-delivered cognitive behavioral therapy for erectile dysfunction. J. Sex. Med. 2011;8:2800–2809.
    1. Andersson G. Clinician-supported internet-delivered psychological treatment of tinnitus. Am. J. Audiol. 2015;24:299–301.
    1. Andersson G. Internet-delivered psychological treatments. Annu. Rev. Clin. Psychol. 2016;12:157–179.
    1. Andersson G., Bergström J., Buhrman M., Carlbring P., Holländare F., Kaldo V., Nilsson-Ihrfelt E., Paxling B., Ström L., Waara J. Development of a new approach to guided self-help via the Internet. The Swedish experience. J. Technol. Hum. Serv. 2008;26:161–181.
    1. Andersson G., Bergström J., Holländare F., Carlbring P., Kaldo V., Ekselius L. Internet-based self-help for depression: a randomised controlled trial. Br. J. Psychiatry. 2005;187:456–461.
    1. Andersson G., Carlbring P., Furmark T., on behalf of the SOFIE Research Group Therapist experience and knowledge acquisition in Internet-delivered CBT for social anxiety disorder: a randomized controlled trial. PLoS One. 2012;7(5)
    1. Andersson G., Carlbring P., Grimlund A. Predicting treatment outcome in Internet versus face to face treatment of panic disorder. Comput. Hum. Behav. 2008;24:1790–1801.
    1. Andersson G., Carlbring P., Holmström A., Sparthan E., Furmark T., Nilsson-Ihrfelt E., Buhrman M., Ekselius L. Internet-based self-help with therapist feedback and in-vivo group exposure for social phobia: a randomized controlled trial. J. Consult. Clin. Psychol. 2006;74:677–686.
    1. Andersson G., Carlbring P., Lindefors N. History and current status of ICBT. In: Lindefors N., Andersson G., editors. Guided Internet-based Treatments in Psychiatry. Springer; Switzerland: 2016.
    1. Andersson G., Cuijpers P., Carlbring P., Riper H., Hedman E. Internet-based vs. face-to-face cognitive behaviour therapy for psychiatric and somatic disorders: a systematic review and meta-analysis. World Psychiatry. 2014;13:288–295.
    1. Andersson G., Hedman E. Effectiveness of guided Internet-delivered cognitive behaviour therapy in regular clinical settings. Verhaltenstherapie. 2013;23:140–148.
    1. Andersson G., Paxling B., Roch-Norlund P., Östman G., Norgren A., Almlöv J., Georén L., Breitholtz E., Dahlin M., Cuijpers P., Carlbring P., Silverberg F. Internet-based psychodynamic vs. cognitive behavioural guided self-help for generalized anxiety disorder: a randomised controlled trial. Psychother. Psychosom. 2012;81:344–355.
    1. Andersson G., Paxling B., Wiwe M., Vernmark K., Bertholds Felix C., Lundborg L., Furmark T., Cuijpers P., Carlbring P. Therapeutic alliance in guided Internet-delivered cognitive behavioral treatment of depression, generalized anxiety disorder and social anxiety disorder. Behav. Res. Ther. 2012;50:544–550.
    1. Andersson G., Rozental A., Shafran R., Carlbring P. Long-term effects of Internet-supported cognitive behavior therapy. Expert. Rev. Neurother. 2018;18:21–28.
    1. Andersson G., Strömgren T., Ström L., Lyttkens L. Randomised controlled trial of Internet based cognitive behavior therapy for distress associated with tinnitus. Psychosom. Med. 2002;64:810–816.
    1. Andersson G., Titov N. Advantages and limitations of Internet-based interventions for common mental disorders. World Psychiatry. 2014;13:4–11.
    1. Andersson G., Waara J., Jonsson U., Malmaeus F., Carlbring P., Öst L.-G. Internet-based self-help vs. one-session exposure in the treatment of spider phobia: a randomized controlled trial. Cogn. Behav. Ther. 2009;38:114–120.
    1. Barak A., Klein B., Proudfoot J.G. Defining Internet-supported therapeutic interventions. Ann. Behav. Med. 2009;38:4–17.
    1. Baumeister H., Reichler L., Munzinger M., Lin J. The impact of guidance on Internet-based mental health interventions — a systematic review. Internet Interv. 2014;1:205–215.
    1. Bendelin N., Hesser H., Dahl J., Carlbring P., Zetterqvist Nelson K., Andersson G. Experiences of guided Internet-based cognitive-behavioural treatment for depression: a qualitative study. BMC Psychiatry. 2011;11:107.
    1. Berger T. The therapeutic alliance in internet interventions: a narrative review and suggestions for future research. Psychother. Res. 2017;27:511–524.
    1. Berger T., Caspar F., Richardson R., Kneubühler B., Sutter D., Andersson G. Internet-based treatment of social phobia: a randomized controlled trial comparing unguided with two types of guided self-help. Behav. Res. Ther. 2011;48:158–169.
    1. Bergman Nordgren L., Carlbring P., Linna E., Andersson G. Role of the working alliance on treatment outcome in tailored internet-based cognitive behavioural therapy for anxiety disorders: randomized controlled pilot trial. JMIR Res. Protoc. 2013;2
    1. Beukes E.W., Baguley D.M., Allen P.M., Manchaiah V., Andersson G. Audiologist guided Internet-based cognitive behaviour therapy for adults with tinnitus in the United Kingdom: a randomised controlled trial. Ear Hear. 2018 (in press)
    1. Boettcher J., Leek L., Matson L., Holmes E.A., Browning M., MacLeod C., Andersson G., Carlbring P. Internet-based attention modification for social anxiety: a randomised controlled comparison of training towards negative and training towards positive cues. PLoS One. 2013;8
    1. Boettcher J., Rozental A., Andersson G., Carlbring P. Side effects in internet-based interventions for social anxiety disorder. Internet Interv. 2014;1:3–11.
    1. Boettcher J., Åström V., Påhlsson D., Schenström O., Andersson G., Carlbring P. Internet-based mindfulness treatment for anxiety disorders: a randomised controlled trial. Behav. Ther. 2014;45:241–253.
    1. Buhrman M., Fältenhag S., Ström L., Andersson G. Controlled trial of Internet-based treatment with telephone support for chronic back pain. Pain. 2004;111:368–377.
    1. Buhrman M., Gordh T., Andersson G. Internet interventions for chronic pain including headache: a systematic review. Internet Interv. 2016;4:17–34.
    1. Buhrman M., Skoglund A., Husell J., Bergström K., Gordh T., Hursti T., Bendelin N., Furmark T., Andersson G. Guided Internet-delivered acceptance and commitment therapy for chronic pain patients: a randomized controlled trial. Behav. Res. Ther. 2013;51:307–315.
    1. Bystedt S., Rozental A., Andersson G., Böttcher J., Carlbring P. Clinicians perspectives on negative effects of psychological treatments. Cogn. Behav. Ther. 2014;43:319–331.
    1. Carlbring P., Andersson G., Cuijpers P., Riper H., Hedman-Lagerlöf E. Internet-based vs. face-to-face cognitive behavior therapy for psychiatric and somatic disorders: an updated systematic review and meta-analysis. Cogn. Behav. Ther. 2018;47:1–18.
    1. Carlbring P., Apelstrand M., Sehlin H., Amir N., Rousseau A., Hofmann S., Andersson G. Internet-delivered attention training in individuals with social anxiety disorder — a double blind randomized controlled trial. BMC Psychiatry. 2012;12:66.
    1. Carlbring P., Hägglund M., Luthström A., Dahlin M., Kadowaki Å., Vernmark K., Andersson G. Internet-based behavioral activation and acceptance-based treatment for depression: a randomized controlled trial. J. Affect. Disord. 2013;148:331–337.
    1. Carlbring P., Maurin L., Törngren C., Linna E., Eriksson T., Sparthan E., Strååt M., Marquez von Hage C., Bergman-Nordgren L., Andersson G. Individually tailored internet-based treatment for anxiety disorders: a randomized controlled trial. Behav. Res. Ther. 2010;49:18–24.
    1. Carlbring P., Nilsson-Ihrfelt E., Waara J., Kollenstam C., Buhrman M., Kaldo V., Söderberg M., Ekselius L., Andersson G. Treatment of panic disorder: live therapy vs. self-help via Internet. Behav. Res. Ther. 2005;43:1321–1333.
    1. Carlbring P., Westling B.E., Ljungstrand P., Ekselius L., Andersson G. Treatment of panic disorder via the Internet — a randomized trial of a self-help program. Behav. Ther. 2001;32:751–764.
    1. Christensen H., Griffiths K.M., Jorm A. Delivering interventions for depression by using the internet: randomised controlled trial. Br. Med. J. 2004;328:265–268.
    1. Clark D.M. Implementing NICE guidelines for the psychological treatment of depression and anxiety disorders: the IAPT experience. International Review of Psychiatry. 2011;23:318–327.
    1. Dahlin M., Andersson G., Magnusson K., Johansson T., Sjögren J., Håkansson A., Pettersson M., Kadowaki Å., Cuijpers P., Carlbring P. Internet-delivered acceptance-based behaviour therapy for generalized anxiety disorder: a randomized controlled trial. Behav. Res. Ther. 2016;77:86–95.
    1. Dekker M.R., Williams A.D. The use of user-centered participatory design in serious games for anxiety and depression. Games Health J. 2017;6:327–333.
    1. Donker T., Blankers M., Hedman E., Ljótsson B., Petrie K., Christensen H. Economic evaluations of Internet interventions for mental health: a systematic review. Psychol. Med. 2015;45:3357–3376.
    1. Drozd F., Vaskinn L., Bergsund H.B., Haga S.M., Slinning K., Bjorkli C.A. The implementation of internet interventions for depression: a scoping review. J. Med. Internet Res. 2016;18
    1. Ebert D., Lehr F., Boß L., Riper H., Cuijpers P., Andersson G., Thiart H., Heber E., Berking M. Efficacy of an Internet-based problem-solving training for teachers: results of a randomized controlled trial. Scand. J. Work Environ. Health. 2014;40:582–596.
    1. El Alaoui S., Hedman E., Kaldo V., Hesser H., Kraepelien M., Andersson E., Rück C., Andersson G., Ljótsson B., Lindefors N. Effectiveness of internet-based cognitive behavior therapy for social anxiety disorder in clinical psychiatry. J. Consult. Clin. Psychol. 2015;83:902–914.
    1. Enander J., Andersson E., Mataix-Cols D., Lichtenstein L., Alström K., Andersson G., Ljótsson B., Rück C. Therapist guided internet based cognitive behavioural therapy for body dysmorphic disorder: single blind randomised controlled trial. Br. Med. J. 2016;352:i241.
    1. Epstein J., Klinkenberg W.D. From Eliza to Internet: a brief history of computerized assessment. Comput. Hum. Behav. 2001;17:295–314.
    1. Fairburn C.G., Patel V. The impact of digital technology on psychological treatments and their dissemination. Behav. Res. Ther. 2017;88:19–25.
    1. Folker A.P., Mathiasen K., Lauridsen S.M., Stenderup E., Dozeman E., Folker M.P. Implementing internet-delivered cognitive behavior therapy for common mental health disorders: a comparative case study of implementation challenges perceived by therapists and managers in five European internet services. Internet Interv. 2018;11:60–70.
    1. Fonagy P. The effectiveness of psychodynamic psychotherapies: an update. World Psychiatry. 2015;14:137–150.
    1. Gotlib I.H., Hammen C.L., editors. Handbook of Depression. The Guilford Press; New York: 2009.
    1. Griffiths K.M., Calear A.L., Banfield M. Systematic review on Internet Support Groups (ISGs) and depression (1): do ISGs reduce depressive symptoms? J. Med. Internet Res. 2009;11
    1. Hadjistavropoulos H.D., Schneider L.H., Edmonds M., Karin E., Nugent M.N., Dirkse D., Dear B.F., Titov N. Randomized controlled trial of internet-delivered cognitive behaviour therapy comparing standard weekly versus optional weekly therapist support. J. Anxiety Disord. 2017;52:15–24.
    1. Hedman E., Andersson E., Ljótsson B., Andersson G., Andersson E.M., Schalling M., Lindefors N., Rück C. Clinical and genetic outcome determinants of Internet- and group-based cognitive behavior therapy for social anxiety disorder. Acta Psychiatr. Scand. 2012;126:126–136.
    1. Hedman E., Andersson G., Ljótsson B., Andersson E., Rück C., Asmundson G.J.G., Lindefors N. Internet-based cognitive-behavioural therapy for severe health anxiety: randomised controlled trial. Br. J. Psychiatry. 2011;198:230–236.
    1. Hedman E., Ljótsson B., Kaldo V., Hesser H., El Alaoui S., Kraepelin M., Andersson E., Rück C., Svanborg C., Andersson G., Lindefors N. Effectiveness of Internet-based cognitive behaviour therapy for depression in routine psychiatric care. J. Affect. Disord. 2014;155:49–58.
    1. Hedman E., Ljótsson B., Rück C., Furmark T., Carlbring P., Lindefors N., Andersson G. Internet administration of self-report measures commonly used in research on social anxiety disorder: a psychometric evaluation. Comput. Hum. Behav. 2010;26:736–740.
    1. Hesser H., Axelsson S., Bäcke V., Engstrand J., Gustafsson T., Holmgren E., Jeppsson U., Pollack M., Norden K., Rosenqvist D., Andersson G. Preventing intimate partner violence via the Internet: a randomized controlled trial of emotion-regulation and conflict-management training for individuals with aggression problems. Clin. Psychol. Psychother. 2017;24:1163–1177.
    1. Hesser H., Gustafsson T., Lundén C., Henriksson O., Fattahi K., Johnsson E., Zetterqvist Westin V., Carlbring P., Mäki-Torkko E., Kaldo V., Andersson G. A randomized controlled trial of Internet-delivered cognitive behavior therapy and acceptance and commitment therapy in the treatment of tinnitus. J. Consult. Clin. Psychol. 2012;80:649–661.
    1. Ivarsson D., Blom M., Hesser H., Carlbring P., Enderby P., Nordberg R., Andersson G. Guided Internet-delivered cognitive behaviour therapy for post-traumatic stress disorder: a randomized controlled trial. Internet Interv. 2014;1:33–40.
    1. Johansson O., Michel T., Andersson G., Paxling B. Experiences of non-adherence to Internet-delivered cognitive behaviour therapy: a qualitative study. Internet Interv. 2015;2:137–142.
    1. Johansson R., Frederick R.J., Andersson G. Using the Internet to provide psychodynamic psychotherapy. Psychodynamic Psychiatry. 2013;41:385–412.
    1. Kaldo-Sandström V., Larsen H.C., Andersson G. Internet-based cognitive-behavioral self-help treatment of tinnitus: clinical effectiveness and predictors of outcome. Am. J. Audiol. 2004;13:185–192.
    1. Kaldo V., Haak T., Buhrman M., Alfonsson S., Larsen H.-C., Andersson G. Internet-based cognitive behaviour therapy for tinnitus patients delivered in a regular clinical setting — outcome and analysis of treatment drop-out. Cogn. Behav. Ther. 2013;42:146–158.
    1. Karyotaki E., Riper H., Twisk J., Hoogendoorn A., Kleiboer A., Mira A., Mackinnon A., Meyer B., Botella C., Littlewood E., Andersson G., Christensen H., Klein J.P., Schröder J., Bretón-López J., Scheider J., Griffiths K., Farrer L., Huibers M.J.H., Phillips R., Gilbody S., Moritz S., Berger T., Pop V., Spek V., Cuijpers P. Efficacy of self-guided internet-based cognitive behavioral therapy in the treatment of depressive symptoms: a meta-analysis of individual participant data. JAMA Psychiatry. 2017;74:351–359.
    1. Kazdin A.E. Mediators and mechanisms of change in psychotherapy research. Annu. Rev. Clin. Psychol. 2007;3:1–27.
    1. King R., Bickman L. Is there a future for therapists? Admin. Pol. Ment. Health. 2017;44:595–597.
    1. Kleiboer A., Smit J., Bosmans J., Ruwaard J., Andersson G., Topooco N., Berger T., Krieger T., Botella C., Banos E., Chevreul K., Araya R., Cerga-Pashoja A., Cieslak R., Rogala A., Vis C., Draisma S., Van Schaik A., Kemmeren L., Ebert D.D., Berking M., Funk B., Cuijpers P., Riper H. European comparative effectiveness research on blended depression treatment versus treatment-as-usual (E-COMPARED): study protocol of a randomized controlled non-inferiority trial in eight European countries. Trials. 2016;17:387.
    1. Klein J.P., Berger T., Schröder J., Späth C., Meyer B., Caspar F., Lutz W., Arndt A., Greiner W., Gräfe V., Hautzinger M., Fuhr K., Rose M., Nolte S., Löwe B., Andersson G., Vettorazzi E., Moritz S., Hohagen F. Effects of a psychological internet intervention in the treatment of mild to moderate depressive symptoms: results of the EVIDENT study, a randomised controlled trial. Psychother. Psychosom. 2016;85:218–228.
    1. Kohn R., Saxena S., Levav I., Saraceno B. The treatment gap in mental health care. Bull. World Health Organ. 2004;82:858–866.
    1. Lange A., van den Ven J.-P., Schrieken B., Emmelkamp P.M.G. Interapy. Treatment of posttraumatic stress through the Internet: a controlled trial. J. Behav. Ther. Exp. Psychiatry. 2001;32:73–90.
    1. Lenhard F., Sauer S., Andersson E., Månsson K.N., Mataix-Cols D., Rück C., Serlachius E. Prediction of outcome in internet-delivered cognitive behaviour therapy for paediatric obsessive-compulsive disorder: a machine learning approach. Int. J. Methods Psychiatr. Res. 2018;27 (in press)
    1. Lindh-Åstrand L., Spetz Holm A.-C., Sydsjö G., Andersson G., Carlbring P., Nedstrand E. Internet-delivered applied relaxation for vasomotor symptoms in postmenopausal women: lessons from a failed trial. Maturitas. 2015;80:432–434.
    1. Lindner P., Carlbring P., Flodman E., Hebert A., Poysti S., Hagkvist F., Johansson R., Zetterqvist Westin V., Berger T., Andersson G. Does cognitive flexibility predict treatment gains in Internet-delivered psychological treatment of social anxiety disorder, depression, or tinnitus? PeerJ. 2016;4
    1. Ljótsson B., Hedman E., Andersson E., Hesser H., Lindfors P., Hursti T., Rydh S., Rück C., Lindefors N., Andersson G. Internet-delivered exposure based treatment vs. stress management for irritable bowel syndrome: a randomized trial. Am. J. Gastroenterol. 2011;106:1481–1491.
    1. Ljótsson B., Hesser H., Andersson E., Lindfors P.-J., Hursti T., Rück C., Lindefors N., Andersson G., Hedman E. Mechanisms of change in exposure-based internet-treatment for irritable bowel syndrome. J. Consult. Clin. Psychol. 2013;81:1113–1126.
    1. Lonsdorf T.B., Rück C., Bergström J., Öhman A., Andersson G., Lindefors N., Schalling M. The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder. BMC Psychiatry. 2010;10:99.
    1. Lundgren J.G., Dahlström Ö., Andersson G., Jaarsma T., Köhler A.K., Johansson P. The effect of guided web-based cognitive behavioral therapy on patients with depressive symptoms and heart failure: a pilot randomized controlled trial. J. Med. Internet Res. 2016;18
    1. Luxton D.D., McCann R.A., Bush N.E., Mishkind M.C., Reger G.M. mHealth for mental health: integrating smartphone technology in behavioral healthcare. Prof. Psychol. Res. Pract. 2011;42:505–512.
    1. Ly K.H., Janni E., Wrede R., Sedem M., Donker T., Carlbring P., Andersson G. Experiences of a guided smartphone-based behavioral activation therapy for depression: a qualitative study. Internet Interv. 2015;2:60–68.
    1. Ly K.H., Topooco N., Cederlund H., Wallin A., Bergström J., Molander O., Carlbring P., Andersson G. Smartphone-supported versus full behavioural activation for depression: a randomised controlled trial. PLoS One. 2015;10
    1. Ly K.H., Trüschel A., Jarl L., Magnusson S., Windahl T., Johansson R., Carlbring P., Andersson G. Behavioral activation vs. mindfulness-based guided self-help treatment administered through a smartphone application: a randomized controlled trial. BMJ Open. 2014;4
    1. Manchaiah V.K.C., Rönnberg J., Andersson G., Lunner T. Use of the 'patient journey' model in the internet-based pre-fitting counseling of a person with hearing disability: lessons from a failed clinical trial. BMC Ear Nose Throat Disord. 2014;14:3.
    1. Marks I.M., Cavanagh K., Gega L. Psychology Press; Hove: 2007. Hands-on Help. Computer-aided Psychotherapy.
    1. Marks I.M., Shaw S., Parkin R. Computer-assisted treatments of mental health problems. Clin. Psychol. Sci. Pract. 1998;5:51–170.
    1. Mohr D.C., Burns M.N., Schueller S.M., Clarke G., Klinkman M. Behavioral intervention technologies: evidence review and recommendations for future research in mental health. Gen. Hosp. Psychiatry. 2013;35:332–338.
    1. Mohr D.C., Siddique J., Ho J., Duffecy J., Jin L., Fokuo J.K. Interest in behavioral and psychological treatments delivered face-to-face, by telephone, and by internet. Ann. Behav. Med. 2010;40:89–98.
    1. Mohr D.C., Zhang M., Schueller S.M. Personal sensing: understanding mental health using ubiquitous sensors and machine learning. Annu. Rev. Clin. Psychol. 2017;13:23–47.
    1. Månsson K.N.T., Carlbring P., Frick A., Engman A., Olsson C.J., Bodlund O., Furmark T., Andersson G. Altered neural correlates of affective processing after internet-delivered cognitive behavior therapy for social anxiety disorder. Psychiatry Res. Neuroimaging. 2013;214:229–237.
    1. Månsson K.N.T., Frick A., Boraxbekk C.-J., Marquand A.F., Williams S.C.R., Carlbring P., Andersson G., Furmark T. Predicting long-term outcome of Internet-delivered cognitive behavior therapy for social anxiety disorder using fMRI and support vector machine learning. Transl. Psychiatry. 2015;5
    1. Månsson K.N.T., Ruiz E., Gervind E., Dahlin M., Andersson G. Development and initial evaluation of an Internet-based support system for face to face cognitive behavior therapy: a proof of concept study. J. Med. Internet Res. 2013;15
    1. Månsson K.N.T., Salami A., Carlbring P., Boraxbekk C.-J., Andersson G., Furmark T. Structural but not functional neuroplasticity one year after effective cognitive behaviour therapy for social anxiety disorders. Behav. Brain Res. 2017;318:45–51.
    1. Månsson K.N.T., Salami A., Frick A., Carlbring P., Andersson G., Furmark T., Boraxbekk C.-J. Neuroplasticity in response to cognitive behavior therapy for social anxiety disorder. Transl. Psychiatry. 2016;6
    1. Nilsson-Ihrfelt E., Fjällskog M.-L., Ahlgren J., Edlund P., Hansen J., Malmberg L., Villman K., Blomqvist C., Andersson G. Breast cancer on the Internet: the quality of Swedish breast cancer web sites. Breast. 2004;11:376–382.
    1. Olsson Halmetoja C., Malmquist A., Carlbring P., Andersson G. Experiences of Internet-delivered cognitive behaviour therapy for social anxiety disorder four years later: a qualitative study. Internet Interv. 2014;1:158–163.
    1. Open Science Collaboration Estimating the reproducibility of psychological science. Science. 2015;349
    1. Paxling B., Almlöv J., Dahlin M., Carlbring P., Breitholtz E., Eriksson T., Andersson G. Guided internet-delivered cognitive behavior therapy for generalized anxiety disorder: a randomized controlled trial. Cogn. Behav. Ther. 2011;40:159–173.
    1. Persson Asplund R., Dagöö J., Fjellström I., Niemi L., Hansson K., Zeraati F., Ziuzina M., Geraedts A., Ljótsson B., Carlbring P., Andersson G. Internet-based stress management for distressed managers: results from a randomised controlled trial. Occup. Environ. Med. 2018;75:105–113.
    1. Rachman S. The evolution of behaviour therapy and cognitive behaviour therapy. Behav. Res. Ther. 2015;64:1–8.
    1. Riper H., Blankers M., Hadiwijaya H., Cunningham J., Clarke S., Wiers R., Ebert D., Cuijpers P. Effectiveness of guided and unguided low-intensity internet interventions for adult alcohol misuse: a meta-analysis. PLoS One. 2014;9
    1. Ritterband L.M., Andersson G., Christensen H.M., Carlbring P., Cuijpers P. Directions for the International Society for Research on Internet Interventions (ISRII) J. Med. Internet Res. 2006;8
    1. Ritterband L.M., Cox D.J., Walker L.S., Kovatchev B., McKnight L., Patel K. An Internet intervention as adjunctive therapy for pediatric encopresis. J. Consult. Clin. Psychol. 2003;71:910–917.
    1. Ritterband L.M., Gonder-Frederick L.A., Cox D.J., Clifton A.D., West R.W., Borowitz S.M. Internet interventions: in review, in use, and into the future. Prof. Psychol. Res. Pract. 2003;34:527–534.
    1. Rozental A., Andersson G., Boettcher J., Ebert D., Cuijpers P., Knaevelsrud C., Ljótsson B., Kaldo V., Titov N., Carlbring P. Consensus statement on defining and measuring negative effects of Internet interventions. Internet Interv. 2014;1:12–19.
    1. Rozental A., Boettcher J., Andersson G., Schmidt B., Carlbring P. Negative effects of Internet interventions: a qualitative content analysis of patients' experiences with treatments delivered online. Cogn. Behav. Ther. 2015;44:223–236.
    1. Rozental A., Forsell E., Svensson A., Andersson G., Carlbring P. Internet-based cognitive behavior therapy for procrastination: a randomized controlled trial. J. Consult. Clin. Psychol. 2015;83:808–824.
    1. Rozental A., Forsell E., Svensson A., Andersson G., Carlbring P. Overcoming procrastination: one-year follow-up and predictors of change in a randomized controlled trial of Internet-based cognitive behavior therapy. Cogn. Behav. Ther. 2017;46:177–195.
    1. Rozental A., Forsström D., Lindner P., Nilsson S., Mårtensson L., Rizzo A., Andersson G., Carlbring P. Treating procrastination using cognitive behavior therapy: a pragmatic randomized controlled trial comparing treatment delivered via the Internet or in groups. Behav. Ther. 2018;49:180–197.
    1. Rozental A., Magnusson K., Boettcher J., Andersson G., Carlbring P. For better or worse: an individual patient data meta-analysis of deterioration among participants receiving Internet-based cognitive behavior therapy. J. Consult. Clin. Psychol. 2017;85:160–177.
    1. Shadish W.R., Matt G.E., Navarro A.M., Siegle G., Crits-Christoph P., Hazelrigg M.D., Jorm M.T., Prout H.T., Robinson L., Smith M.L., Svartberg M., Weiss B. Evidence that therapy works in clinically representative conditions. J. Consult. Clin. Psychol. 1997;65:355–365.
    1. Silfvernagel K., Westlinder A., Andersson S., Bergman K., Hernandez R.D., Fallhagen L., Lundqvist I., Masri N., Viberg L., Forsberg M.-L., Lind M., Berger T., Carlbring P., Andersson G. Individually tailored internet-based cognitive behaviour therapy for older adults with anxiety and depression: a randomised controlled trial. Cogn. Behav. Ther. 2018 (in press)
    1. Sjöstrom M., Umefjord G., Stenlund H., Carlbring P., Andersson G., Samuelsson E. Internet-based treatment of stress urinary incontinence: a randomised controlled study with focus on pelvic floor muscle training. Br. J. Urol. Int. 2013;112:362–372.
    1. Strandskov W.S., Ghaderi A., Andersson H., Parmskog N., Hjort E., Svanberg Wärn A., Jannert M., Andersson G. Effects of tailored and ACT-influenced Internet-based CBT for eating disorders and the relation between knowledge acquisition and outcome: a randomized controlled trial. Behav. Ther. 2017;48:624–637.
    1. Ström L., Pettersson R., Andersson G. A controlled trial of self-help treatment of recurrent headache conducted via the internet. J. Consult. Clin. Psychol. 2000;68:722–727.
    1. Ström M., Uckelstam C.-J., Andersson G., Hassmén P., Umefjord G., Carlbring P. Internet-delivered therapist-guided physical activity for mild to moderate depression: a randomized controlled trial. PeerJ. 2013;1
    1. Thornton L., Batterham P.J., Fassnacht D.B., Kay-Lambkin F., Calear A.L., Hunt S. Recruiting for health, medical or psychosocial research using Facebook: systematic review. Internet Interv. 2016;4:72–81.
    1. Titov N., Andrews G., Kemp A., Robinson E. Characteristics of adults with anxiety or depression treated at an internet clinic: comparison with a national survey and an outpatient clinic. PLoS One. 2010;5
    1. Titov N., Andrews G., Schwencke G., Drobny J., Einstein D. Shyness 1: distance treatment of social phobia over the Internet. Aust. N. Z. J. Psychiatry. 2008;42:585–594.
    1. Titov N., Dear B.F., Staples L., Bennett-Levy J., Klein B., Rapee R.M., Andersson G., Purtell C., Bezuidenhout G., Nielssen O.B. The first 30 months of the MindSpot Clinic: evaluation of a national e-mental health service against project objectives. Aust. N. Z. J. Psychiatry. 2017;51:1227–1239.
    1. Titov N., Fogliati V.J., Staples L.G., Gandy M., Johnston L., Wootton B., Nielssen O., Dear B.F. Treating anxiety and depression in older adults: randomised controlled trial comparing guided v. self-guided internet-delivered cognitive-behavioural therapy. BJPsych Open. 2016;2:50–58.
    1. Topooco N., Riper H., Araya R., Berking M., Brunn M., Chevreul K., Cieslak R., Ebert D.D., Etchmendy E., Herrero R., Kleiboer A., Krieger T., García-Palacios A., Cerga-Pashoja A., Smoktunowicz E., Urech A., Vis C., Andersson G., On behalf of the E-COMPARED Consortium Attitudes towards digital treatment for depression: a European stakeholder survey. Internet Interv. 2017;8:1–9.
    1. van Ballegooijen W., Riper H., Cuijpers P., van Oppen P., Smit J.H. Validation of online psychometric instruments for common mental health disorders: a systematic review. BMC Psychiatry. 2016;16:45.
    1. van Bastelaar K.M., Pouwer F., Cuijpers P., Riper H., Snoek F.J. Web-based depression treatment for type 1 and type 2 diabetic patients: a randomized, controlled trial. Diabetes Care. 2011;34:320–325.
    1. van der Vaart R., Witting M., Riper H., Kooistra L., Bohlmeijer E.T., van Gemert-Pijnen L.J. Blending online therapy into regular face-to-face therapy for depression: content, ratio and preconditions according to patients and therapists using a Delphi study. BMC Psychiatry. 2014;14:355.
    1. Wangberg S.C., Gammon D., Spitznogle K. In the eyes of the beholder: exploring psychologists' attitudes towards and use of e-therapy in Norway. Cyberpsychol. Behav. 2007;10:418–423.
    1. Watkins P.L., Clum G.A., editors. Handbook of Self-help Therapies. Routledge; New York: 2008.
    1. Weise C., Kleinstäuber M., Andersson G. Internet-delivered cognitive-behavior therapy for tinnitus — a randomized controlled trial. Psychosom. Med. 2016;78:501–510.
    1. Vigerland S., Ljótsson B., Bergdahl F., Hagert S., Thulin U., Andersson G., Serlachius E. Attitudes towards the use of computerized cognitive behavior therapy (cCBT) with children and adolescents: a survey among Swedish mental health professionals. Internet Interv. 2014;1:111–117.
    1. Vlaescu G., Alasjö A., Miloff A., Carlbring P., Andersson G. Features and functionality of the Iterapi platform for internet-based psychological treatment. Internet Interv. 2016;6:107–114.
    1. Wootton B.M., Titov N., Dear B.F., Spence J., Kemp A. The acceptability of Internet-based treatment and characteristics of an adult sample with obsessive compulsive disorder: an Internet survey. PLoS One. 2011;6
    1. Yardley L., Morrison L., Bradbury K., Muller I. The person-based approach to intervention development: application to digital health-related behavior change interventions. J. Med. Internet Res. 2015;17
    1. Zetterqvist K., Maanmies J., Ström L., Andersson G. Randomized controlled trial of Internet-based stress management. Cogn. Behav. Ther. 2003;3:151–160.

Source: PubMed

3
Abonneren