Associations between Infant and Parent Characteristics and Measures of Family Well-Being in Neonates with Seizures: A Cohort Study
Linda S Franck, Renée A Shellhaas, Monica Lemmon, Julie Sturza, Janet S Soul, Taeun Chang, Courtney J Wusthoff, Catherine J Chu, Shavonne L Massey, Nicholas S Abend, Cameron Thomas, Elizabeth E Rogers, Charles E McCulloch, Katie Grant, Lisa Grossbauer, Kamil Pawlowski, Hannah C Glass, Neonatal Seizure Registry study group, Ronnie Guillet, Marty Barnes, Tammy Tsuchida, Adam Numis, M Roberta Cilio, Sonia L Bonifacio, Linda S Franck, Renée A Shellhaas, Monica Lemmon, Julie Sturza, Janet S Soul, Taeun Chang, Courtney J Wusthoff, Catherine J Chu, Shavonne L Massey, Nicholas S Abend, Cameron Thomas, Elizabeth E Rogers, Charles E McCulloch, Katie Grant, Lisa Grossbauer, Kamil Pawlowski, Hannah C Glass, Neonatal Seizure Registry study group, Ronnie Guillet, Marty Barnes, Tammy Tsuchida, Adam Numis, M Roberta Cilio, Sonia L Bonifacio
Abstract
Objective: To characterize and determine risk factors for key dimensions of well-being at hospital discharge in families of neonates with acute symptomatic seizures.
Study design: This prospective, observational cohort study enrolled 144 parent-infant dyads among neonates with acute symptomatic seizures from 9 pediatric hospitals in the Neonatal Seizure Registry. One parent per family completed a discharge survey, which included measures of anxiety and depression, health-related quality of life, and impact on the family. Multivariable regression analyses adjusted for site were constructed to examine parent and infant characteristics associated with well-being.
Results: At discharge, 54% of parents reported symptoms of anxiety and 32% reported symptoms of depression. Parents of infants with hypoxic-ischemic encephalopathy reported more depression and worse quality of life than parents of infants with other seizure etiologies. Parental quality of life was also lower with greater infant age at discharge. A higher level of maternal education was associated with greater impact on the family. All these differences were medium to large effect sizes, ranging from 0.52 to 0.78.
Conclusions: Symptoms of anxiety and depression are common in parents of infants with neonatal seizures, and several parent and infant characteristics are associated with poorer parental quality of life and family well-being. These findings are a call to action to improve mental health screening and services for parents of infants with neonatal seizures.
Trial registration: ClinicalTrials.gov NCT02789176.
Keywords: anxiety; depression; family impact; hypoxic-ischemic encephalopathy; intracranial hemorrhage; perinatal ischemic stroke; quality of life.
Conflict of interest statement
Conflict of Interest: Dr. Shellhaas receives royalties from UpToDate for authorship of topics related to neonatal seizures and has served as a consultant for the Epilepsy Study Consortium. Dr. Abend receives royalties from Demos publishing. Dr. Jennifer Guerriero is a consultant for GlaxoSmithKline, Codagenix, Array BioPharma, and Verseau Therapeutics and receives research support from GlaxoSmithKline, Eli Lilly and Array BioPharma for the study of the breast tumor microenvironment. Kamil Pawlowski is an employee of iRhythm technologies.The other authors and individuals listed in Acknowledgments have no conflicts of interest or commercial funding to disclose.
Copyright © 2020 Elsevier Inc. All rights reserved.
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Source: PubMed