The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives
Davor Pavlović, David C A Neville, Olivier Argaud, Baruch Blumberg, Raymond A Dwek, Wolfgang B Fischer, Nicole Zitzmann, Davor Pavlović, David C A Neville, Olivier Argaud, Baruch Blumberg, Raymond A Dwek, Wolfgang B Fischer, Nicole Zitzmann
Abstract
We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.
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Source: PubMed