First Experience Addressing the Prognostic Utility of Novel Urinary Biomarkers in Patients With COVID-19

Udaya S Tantry, Kevin P Bliden, Alastair Cho, Naval Walia, Jeffrey R Dahlen, Gordon Ens, Malina Traianova, Christophe Jerjian, Abira Usman, Paul A Gurbel, Udaya S Tantry, Kevin P Bliden, Alastair Cho, Naval Walia, Jeffrey R Dahlen, Gordon Ens, Malina Traianova, Christophe Jerjian, Abira Usman, Paul A Gurbel

Abstract

Urine 11-dehydro-thromboxane B2 (u11-dh-TxB2), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and liver-type fatty acid binding protein levels (L-FABP) at the time of hospitalization were higher in coronavirus disease 2019 (COVID-19) patients with adverse events vs without events. Higher u11-dh-TxB2 and L-FABP levels were associated with longer hospitalization, more thrombotic events, and greater mortality, providing evidence for potential utility as early prognostic biomarkers for COVID-19.

Keywords: COVID-19; liver-type fatty acid binding protein; urinary 11-dehydro- thromboxane B2; urinary 8-hydroxy-2’-deoxyguanosine.

© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Figures

Figure 1.
Figure 1.
Urinary 11-dehydro-thromboxane B2 in aspirin- and non-aspirin-treated patients with and without events.
Figure 2.
Figure 2.
Mechanistic pathways of urinary biomarkers and relation to coronavirus disease 2019 (COVID-19). COVID-19 is associated with a hypercoagulable state and marked systemic inflammation with resultant tissue ischemia and necrosis. Early elevation in markers of oxidative stress (8-OHdG), proximal glomerular tubular ischemia (L-FABP), and platelet activation/heightened inflammation (11-dehydro-TxB2) found in urine may facilitate assessment of risk.

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