The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: proposal for an evidence-based stage classification system for the forthcoming (8th) edition of the TNM classification of malignant tumors
Frank C Detterbeck, Kelly Stratton, Dorothy Giroux, Hisao Asamura, John Crowley, Conrad Falkson, Pier Luigi Filosso, Aletta A Frazier, Giuseppe Giaccone, James Huang, Jhingook Kim, Kazuya Kondo, Marco Lucchi, Mirella Marino, Edith M Marom, Andrew G Nicholson, Meinoshin Okumura, Enrico Ruffini, Paul Van Schil, Staging and Prognostic Factors Committee, Members of the Advisory Boards, Participating Institutions of the Thymic Domain, Peter Goldstraw, Ramón Rami-Porta, Hisao Asamura, David Ball, Peter MacCallum, David Beer, Ricardo Beyruti, Vanessa Bolejack, Kari Chansky, John Crowley, Frank Detterbeck, Wilfried Ernst Erich Eberhardt, John Edwards, Françoise Galateau-Sallé, Dorothy Giroux, Fergus Gleeson, Patti Groome, James Huang, Catherine Kennedy, Jhingook Kim, Young Tae Kim, Laura Kingsbury, Haruhiko Kondo, Mark Krasnik, Kaoru Kubota, Antoon Lerut, Gustavo Lyons, Mirella Marino, Edith M Marom, Jan van Meerbeeck, Alan Mitchell, Takashi Nakano, Andrew G Nicholson, Royal Brompton, Anna Nowak, Michael Peake, Thomas Rice, Kenneth Rosenzweig, Enrico Ruffini, Valerie Rusch, Nagahiro Saijo, Paul Van Schil, Jean-Paul Sculier, Lynn Shemanski, Kelly Stratton, Kenji Suzuki, Yuji Tachimori, Charles F Thomas Jr, William Travis, Ming S Tsao, Andrew Turrisi, Johan Vansteenkiste, Hirokazu Watanabe, Yi-Long Wu, Conrad Falkson, Pier Luigi Filosso, Giuseppe Giaccone, Kazuya Kondo, Marco Lucchi, Meinoshin Okumura, Paul Baas, Jeremy Erasmus, Seiki Hasegawa, Kouki Inai, Kemp Kernstine, Hedy Kindler, Lee Krug, Kristiaan Nackaerts, Harvey Pass, David Rice, Eugene Blackstone, S Call Caja, U Ahmad, F Detterbeck, N Girard, Seok Jin Haam, Mi Kyung Bae, D R Gomez, E M Marom, P Van Schil, P Ströbel, A Marx, S Saita, H Wakelee, L Bertolaccini, E Vallieres, W Scott, S Su, B Park, J Marks, S Khella, R Shen, M Rosenberg, M Rosenberg, V Tomulescu, J Huang, C Foroulis, L Lang-Lazdunski, Andrea Billè, J G Maessen, M Keijzers, H van Veer, C Wright, M Marino, F Facciolo, G Palmieri, C Buonerba, M Ferguson, G Marulli, M Lucchi, P Loehrer, M Kalkat, K Rohrberg, G Daugaard, A Toker, S Erus, M Kimmich, A Brunelli, M Refai, A Nicholson, E Lim, In Kyu Park, J Wagner, B Tieu, Wentao Fang, Jie Zhang, Zhentao Yu, Yongtao Han, Yin Li, Keneng Chen, Gang Chen, Meinoshin Okumura, Yoshitaka Fujii, Hisao Asamura, Kanji Nagai, Jun Nakajima, Norihiko Ikeda, Shuji Haraguchi, Takamasa Onuki, Kenji Suzuki, Ichiro Yoshino, Masanori Tsuchida, Shoji Takahashi, Kohei Yokoi, Masayuki Hanyuda, Hiroshi Niwa, Hiroshi Date, Yoshimasa Maniwa, Shinichiro Miyoshi, Kazuya Kondo, Akinori Iwasaki, Tatsuro Okamoto, Takeshi Nagayasu, Fumihiro Tanaka, Minoru Suzuki, Kazuo Yoshida, Yusuke Okuma, Hirotoshi Horio, Akihide Matsumura, Masahiko Higashiyama, Hiroshi Suehisa, Takuya Onuki, Yoshifumi Sano, Keishi Kondo, K Al Kattan, R Cerfolio, C Gebitekin, D Gomez de Antonio, K H Kernstine, N Altorki, N Novoa, E Ruffini, P L Filosso, S Saita, M Scarci, L Voltolini, W Weder, Wojciech Zurek, A Arame, C Casadio, P Carbognani, G Donati, S Keshavjee, W Klepetko, B Moser, C Lequaglie, Moishe Liberman, M Mancuso, M Nosotti, L Spaggiari, P A Thomas, E Rendina, F Venuta, M Anile, J Schützner, G Rocco, Hisao Asamura, John Crowley, Frank Detterbeck, Conrad Falkson, Luigi Filosso, Giuseppe Giaccone, Dorothy Giroux, James Huang, Jhingook Kim, Kazuya Kondo, Marco Lucchi, Mirella Marino, Edith M Marom, Andrew G Nicholson, Royal Brompton, Meinoshin Okumura, Enrico Ruffini, Paul Van Schil, Kelly Stratton, Frank C Detterbeck, Kelly Stratton, Dorothy Giroux, Hisao Asamura, John Crowley, Conrad Falkson, Pier Luigi Filosso, Aletta A Frazier, Giuseppe Giaccone, James Huang, Jhingook Kim, Kazuya Kondo, Marco Lucchi, Mirella Marino, Edith M Marom, Andrew G Nicholson, Meinoshin Okumura, Enrico Ruffini, Paul Van Schil, Staging and Prognostic Factors Committee, Members of the Advisory Boards, Participating Institutions of the Thymic Domain, Peter Goldstraw, Ramón Rami-Porta, Hisao Asamura, David Ball, Peter MacCallum, David Beer, Ricardo Beyruti, Vanessa Bolejack, Kari Chansky, John Crowley, Frank Detterbeck, Wilfried Ernst Erich Eberhardt, John Edwards, Françoise Galateau-Sallé, Dorothy Giroux, Fergus Gleeson, Patti Groome, James Huang, Catherine Kennedy, Jhingook Kim, Young Tae Kim, Laura Kingsbury, Haruhiko Kondo, Mark Krasnik, Kaoru Kubota, Antoon Lerut, Gustavo Lyons, Mirella Marino, Edith M Marom, Jan van Meerbeeck, Alan Mitchell, Takashi Nakano, Andrew G Nicholson, Royal Brompton, Anna Nowak, Michael Peake, Thomas Rice, Kenneth Rosenzweig, Enrico Ruffini, Valerie Rusch, Nagahiro Saijo, Paul Van Schil, Jean-Paul Sculier, Lynn Shemanski, Kelly Stratton, Kenji Suzuki, Yuji Tachimori, Charles F Thomas Jr, William Travis, Ming S Tsao, Andrew Turrisi, Johan Vansteenkiste, Hirokazu Watanabe, Yi-Long Wu, Conrad Falkson, Pier Luigi Filosso, Giuseppe Giaccone, Kazuya Kondo, Marco Lucchi, Meinoshin Okumura, Paul Baas, Jeremy Erasmus, Seiki Hasegawa, Kouki Inai, Kemp Kernstine, Hedy Kindler, Lee Krug, Kristiaan Nackaerts, Harvey Pass, David Rice, Eugene Blackstone, S Call Caja, U Ahmad, F Detterbeck, N Girard, Seok Jin Haam, Mi Kyung Bae, D R Gomez, E M Marom, P Van Schil, P Ströbel, A Marx, S Saita, H Wakelee, L Bertolaccini, E Vallieres, W Scott, S Su, B Park, J Marks, S Khella, R Shen, M Rosenberg, M Rosenberg, V Tomulescu, J Huang, C Foroulis, L Lang-Lazdunski, Andrea Billè, J G Maessen, M Keijzers, H van Veer, C Wright, M Marino, F Facciolo, G Palmieri, C Buonerba, M Ferguson, G Marulli, M Lucchi, P Loehrer, M Kalkat, K Rohrberg, G Daugaard, A Toker, S Erus, M Kimmich, A Brunelli, M Refai, A Nicholson, E Lim, In Kyu Park, J Wagner, B Tieu, Wentao Fang, Jie Zhang, Zhentao Yu, Yongtao Han, Yin Li, Keneng Chen, Gang Chen, Meinoshin Okumura, Yoshitaka Fujii, Hisao Asamura, Kanji Nagai, Jun Nakajima, Norihiko Ikeda, Shuji Haraguchi, Takamasa Onuki, Kenji Suzuki, Ichiro Yoshino, Masanori Tsuchida, Shoji Takahashi, Kohei Yokoi, Masayuki Hanyuda, Hiroshi Niwa, Hiroshi Date, Yoshimasa Maniwa, Shinichiro Miyoshi, Kazuya Kondo, Akinori Iwasaki, Tatsuro Okamoto, Takeshi Nagayasu, Fumihiro Tanaka, Minoru Suzuki, Kazuo Yoshida, Yusuke Okuma, Hirotoshi Horio, Akihide Matsumura, Masahiko Higashiyama, Hiroshi Suehisa, Takuya Onuki, Yoshifumi Sano, Keishi Kondo, K Al Kattan, R Cerfolio, C Gebitekin, D Gomez de Antonio, K H Kernstine, N Altorki, N Novoa, E Ruffini, P L Filosso, S Saita, M Scarci, L Voltolini, W Weder, Wojciech Zurek, A Arame, C Casadio, P Carbognani, G Donati, S Keshavjee, W Klepetko, B Moser, C Lequaglie, Moishe Liberman, M Mancuso, M Nosotti, L Spaggiari, P A Thomas, E Rendina, F Venuta, M Anile, J Schützner, G Rocco, Hisao Asamura, John Crowley, Frank Detterbeck, Conrad Falkson, Luigi Filosso, Giuseppe Giaccone, Dorothy Giroux, James Huang, Jhingook Kim, Kazuya Kondo, Marco Lucchi, Mirella Marino, Edith M Marom, Andrew G Nicholson, Royal Brompton, Meinoshin Okumura, Enrico Ruffini, Paul Van Schil, Kelly Stratton
Abstract
A universal and consistent stage classification system, which describes the anatomic extent of a cancer, provides a foundation for communication and collaboration. Thymic epithelial malignancies have seen little progress, in part because of the lack of an official system. The International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group assembled a large retrospective database, a multispecialty international committee and carried out extensive analysis to develop proposals for the 8th edition of the stage classification manuals. This tumor, node, metastasis (TNM)-based system is applicable to all types of thymic epithelial malignancies. This article summarizes the proposed definitions of the T, N, and M components and describes how these are combined into stage groups. This represents a major step forward for thymic malignancies.
Source: PubMed