Adoptive immunotherapy for cancer: building on success
Luca Gattinoni, Daniel J Powell Jr, Steven A Rosenberg, Nicholas P Restifo, Luca Gattinoni, Daniel J Powell Jr, Steven A Rosenberg, Nicholas P Restifo
Abstract
Adoptive cell transfer after host preconditioning by lymphodepletion represents an important advance in cancer immunotherapy. Here, we describe how a lymphopaenic environment enables tumour-reactive T cells to destroy large burdens of metastatic tumour and how the state of differentiation of the adoptively transferred T cells can affect the outcome of treatment. We also discuss how the translation of these new findings might further improve the efficacy of adoptive cell transfer through the use of vaccines, haematopoietic-stem-cell transplantation, modified preconditioning regimens, and alternative methods for the generation and selection of the T cells to be transferred.
Conflict of interest statement
Competing interests statement
The authors declare no competing financial interests.
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Source: PubMed