Controlling the Progression of Curvature in Children and Adolescent Idiopathic Scoliosis Following the Administration of Melatonin, Calcium, and Vitamin D

Alexandru Herdea, Mihai-Codrut Dragomirescu, Alexandru Ulici, Claudiu N Lungu, Adham Charkaoui, Alexandru Herdea, Mihai-Codrut Dragomirescu, Alexandru Ulici, Claudiu N Lungu, Adham Charkaoui

Abstract

Idiopathic scoliosis affects a severe number of children. Their quality of life and development are also disturbed. Some therapeutic strategies have been developed to control illness progression and to optimize the quality of life. In this perspective, randomized, case-control, interventional study, the impact of using melatonin, calcium, and vitamin D, respectively, on idiopathic scoliosis patients was analyzed. Our preliminary results showed that these drugs positively affected the illness progression quantified by the spine curvature. Patients with idiopathic scoliosis may benefit from a novel treatment by supplementation with vitamin D, calcium, and melatonin.

Keywords: calcium; idiopathic scoliosis; melatonin; quality of life; vitamin D.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Follow-up and analysis table for patients in the study “Monitoring the progression of idiopathic scoliosis curvature following the administration of Melatonin 1.5 mg/daily, Calcium 600 mg/daily and Vitamin D 2000 UI/daily. The randomized, case–control, interventional clinical trial”. Initially, when enrolling in the study, both groups did all three tests, then, at six months and one year, only the study group repeated the tests. After six months, the study group repeated only the blood samples for vitamin D and calcium, being only a stage verification. * Other requirements for inclusion were Cobb angle of more then 100 and a Risser score between 0 and 3.
Figure 2
Figure 2
Distribution of patients by age and sex. There were many female patients, a predominant feature of the disease.

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