Night Shift Work and Risk of Depression: Meta-analysis of Observational Studies

Aeyoung Lee, Seung Kwon Myung, Jung Jin Cho, Yu Jin Jung, Jong Lull Yoon, Mee Young Kim, Aeyoung Lee, Seung Kwon Myung, Jung Jin Cho, Yu Jin Jung, Jong Lull Yoon, Mee Young Kim

Abstract

This study aimed to assess whether night shift work is associated with the risk of depression by using a meta-analysis of observational studies. We searched PubMed and EMBASE in August, 2016 to locate eligible studies and investigated the association between night shift work and the risk of depression, reporting outcome measures with adjusted odds ratios (ORs) or relative risks (RRs) and 95% confidence intervals (CIs). In the meta-analysis of a total of 11 observational studies with 9 cross-sectional study, 1 longitudinal study, and 1 cohort study, night shift work was significantly associated with an increased risk of depression (OR/RR, 1.43; 95% CI, 1.24-1.64; I² = 78.0%). Also, subgroup meta-analyses by gender, night shift work duration, type of occupation, continent, and type of publication showed that night shift work was consistently associated with the increased risk of depression. The current meta-analysis suggests that night shift work is associated with the increased risk of depression. However, further large prospective cohort studies are needed to confirm this association.

Keywords: Depression; Meta-analysis; Night Shift Work; Observational Study.

Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

© 2017 The Korean Academy of Medical Sciences.

Figures

Fig. 1
Fig. 1
Flow diagram of identification of relevant studies.
Fig. 2
Fig. 2
Association between night shift work and the risk of depression in a random-effects model meta-analysis of observational studies (n = 11). OR = odds ratio, RR = relative risk, CI = confidence interval. *Random-Effects Model.
Fig. 3
Fig. 3
Begg's funnel plots and Egger's test for identifying publication bias in the meta-analysis of observational studies (n = 11). OR = odds ratio, RR = relative risk, SE = standard error.

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Source: PubMed

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