"First uterine pass effect" is observed when estradiol is placed in the upper but not lower third of the vagina
Ettore Cicinelli, Dominique De Ziegler, Stella Morgese, Carlo Bulletti, Diletta Luisi, Luca Maria Schonauer, Ettore Cicinelli, Dominique De Ziegler, Stella Morgese, Carlo Bulletti, Diletta Luisi, Luca Maria Schonauer
Abstract
In postmenopausal women, the "first uterine pass effect" is seen when E(2) is placed in the upper but not lower third of the vagina.
Source: PubMed