Muscle regeneration after sepsis

Adrien Bouglé, Pierre Rocheteau, Tarek Sharshar, Fabrice Chrétien, Adrien Bouglé, Pierre Rocheteau, Tarek Sharshar, Fabrice Chrétien

Abstract

Severe critical illness is often complicated by intensive care unit-acquired weakness (ICU-AW), which is associated with increased ICU and post-ICU mortality, delayed weaning from mechanical ventilation and long-term functional disability. Several mechanisms have been implicated in the pathophysiology of ICU-AW, but muscle regeneration has not been investigated to any extent in this context, even though its involvement is suggested by the protracted functional consequences of ICU-AW. Recent data suggest that muscle regeneration could be impaired after sepsis, and that mesenchymal stem cell treatment could improve the post-injury muscle recovery.

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