Salvadora persica: Nature's Gift for Periodontal Health

Mohamed Mekhemar, Mathias Geib, Manoj Kumar, Radha, Yasmine Hassan, Christof Dörfer, Mohamed Mekhemar, Mathias Geib, Manoj Kumar, Radha, Yasmine Hassan, Christof Dörfer

Abstract

Salvadora persica (SP) extract, displays very valuable biotherapeutic capacities such as antimicrobial, antioxidant, antiparasitic and anti-inflammatory effects. Numerous investigations have studied the pharmacologic actions of SP in oral disease therapies but its promising outcomes in periodontal health and treatment are not yet entirely described. The current study has been planned to analyze the reported effects of SP as a support to periodontal therapy to indorse regeneration and healing. In consort with clinical trials, in vitro investigations show the advantageous outcomes of SP adjunctive to periodontal treatment. Yet, comprehensive supplementary preclinical and clinical investigations at molecular and cellular levels are indispensable to reveal the exact therapeutic mechanisms of SP and its elements for periodontal health and therapy.

Keywords: Salvadora persica; adjunctive periodontal therapy; anti-inflammatory agents; antioxidants; herbal medicine; oral health; periodontal disease; periodontitis.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structures of important phytoconstituents present in the Salvadora persica extract.
Figure 2
Figure 2
Mode of action of Salvadora persica as an adjunctive periodontal chemotherapeutic in periodontal disease. Abbreviations: IL-1β: interleukin 1b, IL-6: interleukin 6, IL-8: interleukin 8, TNF-α: tumor-necrosis-factor-α, IFN: interferon, NOS: nitric oxide synthase, TGF-β1: transforming growth factor-β1.

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