Effects of vitamin D deficiency on the rate of orthodontic tooth movement: An animal study

Rawan M Khalaf, Abdullazez A Almudhi, Rawan M Khalaf, Abdullazez A Almudhi

Abstract

Bone remodeling and orthodontic tooth movement (OTM) are controlled by certain essential molecules, one of which is vitamin D. Increased levels of vitamin D have been associated with increased rates of OTM. The purpose of this study was to determine the effect of vitamin D deficiency on the rate of OTM, and to determine their association after applying orthodontic forces.

Materials and methods: Wistar rats were divided into two groups: control group with average vitamin D levels and experimental group with induced vitamin D deficiency. Orthodontic appliances were fixed to initiate tooth movement. Distance between the reference teeth were measured in millimeters on day zero, and repeated every 7 days, till day 21.

Results: A significant difference within the experimental group was found; as well as within the control group, there was also no significant interaction between time and the type of group.

Conclusion: The rate of Orthodontic tooth movement was not affected by induced vitamin D deficiency in rats.

Keywords: Animal studies; C, Control; E, experimental; OTM, Orthodontic tooth movement; Orthodontic force; Orthodontic tooth movement; RANKL/OPG ratio, Receptor Activator of Nuclear Factor Kappa B Ligand/ Osteoprotegerin ratio; Tooth movement; Vit D, Vitamin D; Vitamin D deficiency; g, grams; male Wistar rats.

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

© 2021 The Authors.

Figures

Graphical abstract
Graphical abstract
Fig. 1
Fig. 1
Orthodontic Appliance.
Fig. 2
Fig. 2
Change in OTM over time.

References

    1. Al-Hasani N.R., Al-Bustani A.I., Ghareeb M.M., Hussain S.A. Clinical efficacy of locally injected calcitriol in orthodontic tooth movement. Int. J. Pharm. Pharm. Sci. 2011;3:139–143.
    1. Al-Zoughool M., AlShehri A., Alqarni A., Alarfaj A., Tamimi W. Vitamin D Status of Patients Visiting Health Care Centers in the Coastal and Inland Cities of Saudi Arabia. J. Public Heal. Dev. Ctries. 2015;1:14–21.
    1. Alansari, S., Sangsuwon, C., Vongthongleur, T., Kwal, R., Teo, M. chneh, Lee, Y.B., Nervina, J., Teixeira, C., Alikhani, M., 2015. Biological principles behind accelerated tooth movement. Semin. Orthod. 21, 151–161. Doi: 10.1053/j.sodo.2015.06.001.
    1. Ardawi M.-S.-M., Sibiany A.M., Bakhsh T.M., Qari M.H., Maimani A.A. High prevalence of vitamin D deficiency among healthy Saudi Arabian men: relationship to bone mineral density, parathyroid hormone, bone turnover markers, and lifestyle factors. Osteoporos. Int. a J. Establ. as result Coop. between Eur Found. Osteoporos. Natl. Osteoporos. Found. USA. 2012;23:675–686. doi: 10.1007/s00198-011-1606-1.
    1. Bakathir M.A., Linjawi A.I., Omar S.S., Aboqura A.B., Hassan A.H. Effects of nicotine on bone during orthodontic tooth movement in male rats. Histological and immunohistochemical study. Saudi Med. J. 2016;37:1127–1135. doi: 10.15537/smj.2016.10.15159.
    1. Bartzela T., Türp J.C., Motschall E., Maltha J.C. Medication effects on the rate of orthodontic tooth movement: a systematic literature review. Am. J. Orthod. Dentofac. Orthop. Off. Publ. Am. Assoc. Orthod. its Const. Soc. Am. Board Orthod. 2009;135:16–26. doi: 10.1016/j.ajodo.2008.08.016.
    1. Boyce B.F., Xing L. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res. Ther. 2007;9:S1. doi: 10.1186/ar2165.
    1. Brudvik P., Rygh P. The initial phase of orthodontic root resorption incident to local compression of the periodontal ligament. Eur. J. Orthod. 1993;15:249–263. doi: 10.1093/ejo/15.4.249.
    1. Charan J., Kantharia N.D. How to calculate sample size in animal studies? J. Pharmacol. Pharmacother. 2013;4:303–306. doi: 10.4103/0976-500X.119726.
    1. Curl L., Tan C.W., Dreyer C.W., Sampson W. A qualitative investigation of RANKL, RANK and OPG in a rat model of transient ankylosis. Aust. Orthod. J. 2014;30:143–151.
    1. Elsammak M., Al-Wosaibi A.A., Al-Howeish A., Alsaeed J. Vitamin D Deficiency in Saudi Arabs. Horm. Metab. Res. 2010;42:364–368. doi: 10.1055/s-0030-1248296.
    1. Franzon Frigotto, G.C., Miranda de Araujo, C., Guariza Filho, O., Tanaka, O.M., Batista Rodrigues Johann, A.C., Camargoa, E.S., 2015. Effect of fluoxetine on induced tooth movement in rats. Am. J. Orthod. Dentofac. Orthop. Off. Publ. Am. Assoc. Orthod. its Const. Soc. Am. Board Orthod. 148, 450–456. Doi: 10.1016/j.ajodo.2015.04.031
    1. Gameiro, G.H., Pereira-Neto, J.S., Magnani, M.B.B. de A., Nouer, D.F., 2007. The influence of drugs and systemic factors on orthodontic tooth movement. J. Clin. Orthod. 41, 73–8; quiz 71.
    1. Haines S.T., Park S.K. Vitamin D supplementation: What’s known, what to do, and what’s needed. Pharmacotherapy. 2012;32:354–382. doi: 10.1002/phar.1037.
    1. Kobayashi Y., Hashimoto F., Miyamoto H., Kanaoka K., Miyazaki-Kawashita Y., Nakashima T., Shibata M., Kobayashi K., Kato Y., Sakai H. Force-induced osteoclast apoptosis in vivo is accompanied by elevation in transforming growth factor beta and osteoprotegerin expression. J. bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res. 2000;15:1924–1934. doi: 10.1359/jbmr.2000.15.10.1924.
    1. Leiker B.J., Nanda R.S., Currier G.F., Howes R.I., Sinha P.K. The effects of exogenous prostaglandins on orthodontic tooth movement in rats. Am. J. Orthod. Dentofac. Orthop. Off. Publ. Am. Assoc. Orthod. its Const. Soc. Am. Board Orthod. 1995;108:380–388. doi: 10.1016/s0889-5406(95)70035-8.
    1. Nimeri G., Kau C.H., Abou-Kheir N.S., Corona R. Acceleration of tooth movement during orthodontic treatment–a frontier in orthodontics. Prog. Orthod. 2013;14:42. doi: 10.1186/2196-1042-14-42.
    1. Nimeri, G., Kau, C.H., Abou-kheir, N.S., Corona, R., Davidovitch, Z., Meikle, M., Davidovitch, Z., Nicolay, O., Ngan, P., Shanfeld, J., Krishnan, V., Davidovitch, Z., Burstone, C., Tanne, K., Garlet, T., Coelho, U., Silva, J., Garlet, G., Leiker, B., Nanda, R., Currier, G., Howes, R., Sinha, P., Krishnan, V., Davidovitch, Z., Saito, M., Saito, S., Ngan, P., Shanfeld, J., Davidovitch, Z., Yamasaki, K., Miura, F., Suda, T., Yamasaki, K., Shibata, Y., Fukuhara, T., Yamasaki, K., Shibata, Y., Imai, S., Tani, Y., Shibasaki, Y., Fukuhara, T., Seifi, M., Eslami, B., Saffar, A., Kanzaki, H., Chiba, M., Arai, K., Takahashi, I., Haruyama, N., Nishimura, M., Mitani, H., Nishijima, Y., Yamaguchi, M., Kojima, T., Aihara, N., Nakajima, R., Kasai, K., Collins, M., Sinclair, P., Kale, S., Kocadereli, I., Atilla, P., Asan, E., Soma, S., Iwamoto, M., Higuchi, Y., Kurisu, K., Soma, S., Matsumoto, S., Higuchi, Y., Takano-Yamamoto, T., Yamashita, K., Kurisu, K., Iwamoto, M., Liu, Z., King, G., Gu, G., Shin, J., Stewart, D., Madan, M., Liu, Z., Gu, G., King, G., McGorray, S., Dolce, C., Kramer, S., Stewart, D., Wheeler, T., Udagawa, N., Takahashi, N., Jimi, E., Matsuzaki, K., Tsurukai, T., Itoh, K., Nakagawa, N., Yasuda, H., Goto, M., Tsuda, E., Higashio, K., Gillespie, M., Martin, T., Suda, T., Drugarin, D., Negru, S., Cioace, R., Kim, S., Kang, Y., Park, J., Kim, E., Park, Y., Simonet, W., Lacey, D., Dunstan, C., Kelley, M., Chang, M., Luthy, R., Nguyen, H., Wooden, S., Bennett, L., Boone, T., Shimamoto, G., DeRose, M., Elliott, R., Colombero, A., Tan, H., Trail, G., Sullivan, J., Davy, E., Bucay, N., Renshaw-Gegg, L., Hughes, T., Hill, D., Pattison, W., Campbell, P., Sander, S., Van, G., Tarpley, J., Derby, P., Lee, R., Boyle, W., Oshiro, T., Shiotani, A., Shibasaki, Y., Sasaki, T., Kanzaki, H., Chiba, M., Takahashi, I., Haruyama, N., Nishimura, M., Mitani, H., Yamaguchi, M., Takano-Yamamoto, T., Rodan, G., Nicozisis, J., Nah-Cederquist, H., Tuncay, O., Han, G., He, H., Hua, X., Wang, S., Zeng, X., Bumann, A., Carvalho, R., Schwarzer, C., Yen, E., Masella, R., Meister, M., Nishimura, M., Chiba, M., Ohashi, T., Sato, M., Shimizu, Y., Igarashi, K., Mitani, H., Kau, C.H., Davidovitch, Z., Finkelson, M., Steigman, S., Shanfeld, J., Montgomery, P., Korostoff, E., Fujita, S., Yamaguchi, M., Utsunomiya, T., Yamamoto, H., Kasai, K., Kawasaki, K., Shimizu, N., Limpanichkul, W., Godfrey, K., Srisuk, N., Rattanayatikul, C., Kau, C.H., Kantarci, A., Shaughnessy, T., Vachiramon, A., Santiwong, P., la-Fuente, A. da, Doshi-Mehta, G., Bhad-Patil, W., Zengo, A., Bassett, C., Pawluk, R., Prountzos, G., Shimizu, Y., Kakehi, N., Yamazaki, T., Tsugawa, W., Sode, K., Kolahi, J., Abrishami, M., Davidovitch, Z., Saito, S., Shimizu, N., Trelles, M., Mayayo, E., Takeda, Y., Karu, T., Eells, J., Henry, M., Summerfelt, P., Wong-Riley, M., Buchmann, E., Kane, M., Whelan, N., Whelan, H., Liou, E., Huang, C., Ren, A., Lv, T., Kang, N., Zhao, B., Chen, Y., Bai, D., Sukurica, Y., Karaman, A., Gurel, H., Dolanmaz, D., Kisnisci, R., Iseri, H., Tuz, H., Altug, A., Iseri, H., Kisnisci, R., Bzizi, N., Tuz, H., Sayin, S., Bengi, A., Gurton, A., Ortakoglu, K., Lee, W., Karapetyan, G., Moats, R., Yamashita, D., Moon, H., Ferguson, D., Yen, S., Wilcko, W., Wilcko, T., Bouquot, J., Ferguson, D., Baloul, S., Gerstenfeld, L., Morgan, E., Carvalho, R., Van-Dyke, T., Kantarci, A., Aboul-Ela, S., El-Beialy, A., El-Sayed, K., Selim, E., El-Mangoury, N., Mostafa, Y., Han, X., Meng, Y., Kang, N., Lv, T., Bai, D., Dibart, S., Surmenian, J., Sebaoun, J., Montesani, L., Hassan, N., Sa, I., Keser, E., Dibart, S., Ilizarov, G., Wang, L., Lee, W., Lei, D., Liu, Y., Yamashita, D., Yen, S., Kole, H., Generson, R., Porter, J., Zell, A., Stratigos, G., Anholm, J., Crites, D., Hoff, R., Rathbun, W., Gantes, B., Rathbun, E., Anholm, M., Suya, H., Nazarov, A., Ferguson, D., Wilcko, W., Wilcko, M., Mittal, S., Singla, A., 2013b. Acceleration of tooth movement during orthodontic treatment - a frontier in Orthodontics. Prog. Orthod. 14, 42. Doi: 10.1186/2196-1042-14-42.
    1. Peron A.P.L.M., Johann A.C.B.R., Papalexiou V., Tanaka O.M., Guariza-Filho O., Ignácio S.A., Camargo E.S. Tissue responses resulting from tooth movement surgically assisted by corticotomy and corticision in rats. Angle Orthod. 2017;87:118–124. doi: 10.2319/102915-731.1.
    1. Reynolds J.J., Holick M.F., De Luca H.F. The role of vitamin D metabolites in bone resorption. Calcif. Tissue Res. 1973;12:295–301. doi: 10.1007/BF02013742.
    1. Seifi M., Eslami B., Saffar A.S. The effect of prostaglandin E2 and calcium gluconate on orthodontic tooth movement and root resorption in rats. Eur. J. Orthod. 2003;25:199–204. doi: 10.1093/ejo/25.2.199.
    1. Seifi, M., Hamedi, R., Khavandegar, Z., 2015. The Effect of Thyroid Hormone, Prostaglandin E2, and Calcium Gluconate on Orthodontic Tooth Movement and Root Resorption in Rats. J. Dent. (Shiraz, Iran) 16, 35–42.
    1. Stavenuiter A.W.D., Arcidiacono M.V., Ferrantelli E., Keuning E.D., Vila Cuenca M., ter Wee P.M., Beelen R.H.J., Vervloet M.G., Dusso A.S. A novel rat model of vitamin D deficiency: safe and rapid induction of vitamin D and calcitriol deficiency without hyperparathyroidism. Biomed. Res. Int. 2015;2015 doi: 10.1155/2015/604275.
    1. Taddei, S.R. de A., Moura, A.P., Andrade, I.J., Garlet, G.P., Garlet, T.P., Teixeira, M.M., da Silva, T.A., 2012. Experimental model of tooth movement in mice: a standardized protocol for studying bone remodeling under compression and tensile strains. J. Biomech. 45, 2729–2735. Doi: 10.1016/j.jbiomech.2012.09.006.
    1. Takano-Yamamoto T., Kawakami M., Yamashiro T. Effect of age on the rate of tooth movement in combination with local use of 1,25(OH)2D3 and mechanical force in the rat. J. Dent. Res. 1992;71:1487–1492. doi: 10.1177/00220345920710080501.
    1. Venkataramana V, Rajasigamani K, Kurunjikumaran N, A.M., 2012. The Effect of Bisphosphonate [Pamidronate] On Orthodontic Tooth Movement in Rabbits. IOSR J. Dent. Med. Sci. 1, 21–26.
    1. Venkataramana, V., Rajasigamani, K., Madhavan, N., Reddy, S.N., Karthik, KurunjiKumaran, N., 2012. Inhibitory effect of bisphosphonate [pamidronate] on orthodontic tooth movement in Newzealand albino rabbits. J. Int. Dent. Med. Res. 5, 136–142.
    1. Waldo C.M., Rothblatt J.M. Histologic Response to Tooth Movement in the Laboratory Rat: Procedure and Preliminary Observations. J. Dent. Res. 1954;33:481–486. doi: 10.1177/00220345540330040701.

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