Educational Case: Burn Injury-Pathophysiology, Classification, and Treatment
Seth I Noorbakhsh, Eric M Bonar, Rachel Polinski, Md Shahrier Amin, Seth I Noorbakhsh, Eric M Bonar, Rachel Polinski, Md Shahrier Amin
Abstract
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.1.
Keywords: disease mechanism; environmental mechanisms; pathology competencies; physical injury; thermal injury.
Conflict of interest statement
Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
© The Author(s) 2021.
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References
- Knollmann-Ritschel BEC, Regula DP, Borowitz MJ, Conran R, Prystowsky MB. Pathology competencies for medical education and educational cases. Acad Pathol. 2017;4. doi:10.1177/2374289517715040
- Hettiaratchy S, Papini R. Initial management of a major burn: II—assessment and resuscitation. BMJ. 2004;329:101–103. doi:10.1136/bmj.329.7457.101
- Hettiaratchy S, Dziewulski P. Pathophysiology and types of burns. BMJ. 2004;328:1427–1429. doi:10.1136/bmj.328.7453.1427
- Kagan RJ, Peck MD, Ahrenholz DH, et al. Surgical management of the burn wound and use of skin substitutes: an expert panel white paper. J Burn Care Res. 2013;34:e60–79. doi:10.1097/BCR.0b013e31827039a6
- Serrano C, Boloix-Tortosa R, Gómez-Cía T, Acha B. Features identification for automatic burn classification. Burns. 2015;41:1883–1890. doi:10.1016/j.burns.2015.05.011
- Monstrey S, Hoeksema H, Verbelen J, Pirayesh A, Blondeel P. Assessment of burn depth and burn wound healing potential. Burns. 2008;34:761–769. doi:10.1016/j.burns.2008.01.009
- Rice PL, Jr, Orgill DP. Assessment and classification of burn injury. In: Post TW, ed. UpToDate. Published February 25, 2021. Accessed March 23, 2021.
- Roshangar L, Soleimani Rad J, Kheirjou R, Reza Ranjkesh M, Ferdowsi Khosroshahi A. Skin burns: review of molecular mechanisms and therapeutic approaches. Wounds. 2019;31:308–315.
- Abdulkhaleq LA, Assi MA, Abdullah R, Zamri-Saad M, Taufiq-Yap YH, Hezmee MNM. The crucial roles of inflammatory mediators in inflammation: a review. Vet World. 2018;11:627–635. doi:10.14202/vetworld.2018.627-635
- Juhn SK, Jung M-K, Hoffman MD, et al. The role of inflammatory mediators in the pathogenesis of otitis media and sequelae. Clin Exp Otorhinolaryngol. 2008;1:117. doi:10.3342/ceo.2008.1.3.117
- Tiwari VK. Burn wound: how it differs from other wounds? Indian J Plast Surg. 2012;45:364–373. doi:10.4103/0970-0358.101319
- Grubbs H, Manna B. Wound physiology. In: StatPearls. StatPearls Publishing. Published July 26, 2020. Accessed March 23, 2021.
- Ogawa R. Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int J Mol Sci. 2017;18:606. doi:10.3390/ijms18030606
- Wiktor A, Richards D. Treatment of minor thermal burns. In: Post TW, ed. UpToDate. Published December 9, 2019. Accessed March 29, 2021.
- World Health Organization. The ABCDE and SAMPLE History Approach—Basic Emergency Care Course. Published Online 2018. Accessed March 23, 2021.
- Voigt CD, Celis M, Voigt DW. Care of outpatient burns. In: Herndon D, ed. Total Burn Care. 5th ed. Elsevier; 2017. Chapter 6.
- Short A., Roth JJ, Hughes WB. The Essential Burn Unit Handbook. St Louis: QMP, 2004, (paperback); pp141. Crit Care. 2004;9:E9. doi:10.1186/cc2990
- Gauglitz GG, Williams FN. Overview of the management of the severely burned patient. In: Post TW, ed. UpToDate. Published May 10, 2021. Accessed March 29, 2021.
- Rice PL, Jr, Orgill DP. Emergency care of moderate and severe thermal burns in adults. In: Post Ted. W., ed. UpToDate. Published October 1, 2019. Accessed March 23, 2021.
- Lund T, Onarheim H, Reed RK. Pathogenesis of edema formation in burn injuries. World J Surg. 1992;16:2–9. doi:10.1007/BF02067107
- Gauglitz GG, Williams FN. Overview of complications of severe burn injury. In: Post TW, ed. UpToDate. Published March 5, 2020. Accessed March 23, 2021.
- Puri V, Khare NA, Chandramouli MV, Shende N, Bharadwaj S. Comparative analysis of early excision and grafting vs delayed grafting in burn patients in a developing country. J Burn Care Res. 2016;37:278–282. doi:10.1097/BCR.0b013e31827e4ed6
- Bernal E, Phelan HA. Treatment of deep burns. In: Post TW, ed. UpToDate. Published December 17, 2019. Accessed March 23, 2021.
- Voigt CD, Williamson S, Kagan RJ, et al. The skin bank. In: Herndon D, ed. Total Burn Care. 5th ed. Elsevier; 2017. Chapter 14.
- Gauglitz GG, Williams FN, Shahrokhi S. Burn wound infection and sepsis. In: Post TW, ed. UpToDate. Published June 11, 2021. Accessed June 29, 2021.
- Cambiaso-Daniel J, Gallagher JJ, Norbury WB, et al. Treatment of infection in burn patients. In: Herndon D, ed. Total Burn Care. 5th ed. Elsevier; 2017. Chapter 11.
- Brownson EG, Gibran NS. Evaluation of the burn wound: management decisions. In: Herndon D, ed. Total Burn Care. 5th ed. Elsevier; 2017. Chapter 10.
- Pinto DS, Clardy PF. Environmental and weapon-related electrical injuries. In: Post TW, ed. UpToDate. Published January 22, 2021. Accessed March 23, 2021.
- Benjamin DA, Jaco M. Burn nursing. In: Herndon D, ed. Total Burn Care. 5th ed. Elsevier; 2017. Chapter 33.
- Wiktor A, Richards D. Treatment of minor thermal burns. In: Post TW, ed. UpToDate. Published December 9, 2019. Accessed March 23, 2021.
- Maguire S, Moynihan S, Mann M, Potokar T, Kemp AM. A systematic review of the features that indicate intentional scalds in children. Burns. 2008;34:1072–1081. doi:10.1016/j.burns.2008.02.011
- Wiechman SA, Patterson DR. Psychosocial aspects of burn injuries. BMJ. 2004;329:391–393. doi:10.1136/bmj.329.7462.391
- Murphy S, Clark DE, Carter DW. Racial disparities exist among burn patients despite insurance coverage. Am J Surg. 2019;218:47–50. doi:10.1016/j.amjsurg.2018.08.013
- Gauglitz GG. Hypertrophic scarring and keloids following burn injuries. In: Post TW, ed. UpToDate. Published October 21, 2019. Accessed March 23, 2021.
Source: PubMed