The impact on ovarian reserve after laparoscopic ovarian cystectomy versus three-stage management in patients with endometriomas: a prospective randomized study
Dimitrios Tsolakidis, George Pados, Dimitrios Vavilis, Dimitrios Athanatos, Tryfon Tsalikis, Anastasia Giannakou, Basil C Tarlatzis, Dimitrios Tsolakidis, George Pados, Dimitrios Vavilis, Dimitrios Athanatos, Tryfon Tsalikis, Anastasia Giannakou, Basil C Tarlatzis
Abstract
Objective: To investigate the effect of two different laparoscopic methods on ovarian reserve in patients with ovarian endometriomas.
Design: Prospective, randomized clinical trial.
Setting: Endoscopy unit of a university hospital.
Patient(s): Twenty women with endometriomas.
Intervention(s): Patients were randomly selected to undergo either laparoscopic cystectomy for endometrioma (group 1) or the "three-step procedure" (group 2). Before and 6 months after laparoscopy all patients were evaluated, and 12 months postoperatively they underwent ultrasound scan examination.
Main outcome measure(s): The primary end point was ovarian reserve damage based on the alterations of anti-Müllerian hormone (AMH). Secondary end points were the changes of antral follicle count and serum concentration of FSH, LH, E(2), and inhibin B.
Result(s): Mean serum AMH was reduced significantly from 3.9-2.9 ng/mL in group 1 compared with the reduction from 4.5-3.99 ng/mL in group 2.
Conclusion(s): Ovarian reserve determined by AMH is less diminished after the three-step procedure compared with cystectomy of endometriomas.
Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Source: PubMed