Autism profiles of males with fragile X syndrome

Susan W Harris, David Hessl, Beth Goodlin-Jones, Jessica Ferranti, Susan Bacalman, Ingrid Barbato, Flora Tassone, Paul J Hagerman, Herman Herman, Randi J Hagerman, Susan W Harris, David Hessl, Beth Goodlin-Jones, Jessica Ferranti, Susan Bacalman, Ingrid Barbato, Flora Tassone, Paul J Hagerman, Herman Herman, Randi J Hagerman

Abstract

Autism, which is common in individuals with fragile X syndrome, is often difficult to diagnose. We compared the diagnostic classifications of two measures for autism diagnosis, the ADOS and the ADI-R, in addition to the DSM-IV-TR in 63 males with this syndrome. Overall, 30% of the subjects met criteria for autistic disorder and 30% met criteria for PDD-NOS. The classifications on the ADOS and DSM-IV-TR were most similar, whereas the ADI-R classified subjects as autistic much more frequently. We further investigated the relationship of both FMRP and FMRI mRNA to symptoms of autism in this cohort and found no significant relationship between the measures of autism and molecular features, including FMRP, FMRI mRNA, and CGG repeat number.

Figures

Figure 1. Autism Classification of sample: ADI-R,…
Figure 1. Autism Classification of sample: ADI-R, ADOS, and DSM-IV-TR
Figure 2. ADOS Module 1
Figure 2. ADOS Module 1
Module 1 Communication + Social Total (Comm-Soc) can range from 0 to 24. Module 1 Autism cutoff=12, autism spectrum cutoff=4. Module 1 Stereotyped Behaviors and Restricted Interests Score (RB) can range from 0 to 6 (this score, however, is not used in the algorithm used to determine the overall autism classification of the ADOS).

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