Executive Functions and Rapid Automatized Naming: A New Tele-Rehabilitation Approach in Children with Language and Learning Disorders

Agnese Capodieci, Marco Romano, Emanuela Castro, Maria Chiara Di Lieto, Silvia Bonetti, Silvia Spoglianti, Chiara Pecini, Agnese Capodieci, Marco Romano, Emanuela Castro, Maria Chiara Di Lieto, Silvia Bonetti, Silvia Spoglianti, Chiara Pecini

Abstract

Executive function deficits are documented in many neurodevelopmental disorders and may contribute to clinical complexity or rehabilitation resilience. The present research was primarily aimed at presenting and evaluating the feasibility and effectiveness of a telerehabilitation program used during the pandemic period. MemoRAN (Anastasis), a computerised cognitive training to improve executive control during visual-verbal integration tasks was used in a sample of 42 children (5-11 years old) with specific learning or language disorders. The MemoRAN training was based on exercises of inhibition, cognitive flexibility and updating in working memory for three months, with a frequency of approximately three sessions per week. Afterwards, a comparison between a subgroup of children using Memo-RAN and an active control group, using a tele-rehabilitation program directed on reading was conducted. Effect size analysis in pre-post measurements suggests an average effect of MemoRAN in measurements that require control processes, such as accuracy in dictation, reading, inhibition and working memory testing. Comparison with the active control group and the clinical utility implications of these types of treatment will be discussed.

Keywords: computerised cognitive training; executive function; language disorder; learning disabilities; rapid automatized naming; tele-rehabilitation; working memory.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Types of stimuli presentation (in order single stimulus, progressive, anti-progressive and all visible).
Figure 2
Figure 2
Example of monitoring screen.

References

    1. de Oliveira Rosa V., Rosa Franco A., Abrahão Salum Júnior G., Moreira-Maia C.R., Wagner F., Simioni A., de Fraga Bassotto C., Moritz G.R., Schaffer Aguzzoli C., Buchweitz A., et al. Effects of Computerized Cognitive Training as Add-on Treatment to Stimulants in ADHD: A Pilot FMRI Study. Brain Imaging Behav. 2020;14:1933–1944. doi: 10.1007/s11682-019-00137-0.
    1. Wiest D.J., Wong E.H., Bacon J.M., Rosales K.P., Wiest G.M. The Effectiveness of Computerized Cognitive Training on Working Memory in a School Setting. Appl. Cogn. Psychol. 2020;34:465–471. doi: 10.1002/acp.3634.
    1. Gathercole S.E., Dunning D.L., Holmes J., Norris D. Corrigendum to ‘Working Memory Training Involves Learning New Skills’. J. Mem. Lang. 2019;106:203. doi: 10.1016/j.jml.2019.02.004.
    1. Rabiner D.L., Murray D.W., Skinner A.T., Malone P.S. A Randomized Trial of Two Promising Computer-Based Interventions for Students with Attention Difficulties. J. Abnorm. Child. Psychol. 2010;38:131–142. doi: 10.1007/s10802-009-9353-x.
    1. Jones J.S., Milton F., Mostazir M., Adlam A.R. The Academic Outcomes of Working Memory and Metacognitive Strategy Training in Children: A Double-Blind Randomized Controlled Trial. Dev. Sci. 2020;23:e12870. doi: 10.1111/desc.12870.
    1. Harder L., Hernandez A., Hague C., Neumann J., McCreary M., Cullum C.M., Greenberg B. Home-Based Pediatric Teleneuropsychology: A Validation Study. Arch. Clin. Neuropsychol. 2020;35:1266–1275. doi: 10.1093/arclin/acaa070.
    1. Kronenberger W.G., Montgomery C.J., Henning S.C., Ditmars A., Johnson C.A., Herbert C.J., Pisoni D.B. Remote Assessment of Verbal Memory in Youth with Cochlear Implants during the COVID-19 Pandemic. Am. J. Speech. Lang. Pathol. 2021;30:740–747. doi: 10.1044/2021_AJSLP-20-00276.
    1. Ragbeer S.N., Augustine E.F., Mink J.W., Thatcher A.R., Vierhile A.E., Adams H.R. Remote Assessment of Cognitive Function in Juvenile Neuronal Ceroid Lipofuscinosis (Batten Disease): A Pilot Study of Feasibility and Reliability. J. Child. Neurol. 2016;31:481–487. doi: 10.1177/0883073815600863.
    1. Stain H.J., Payne K., Thienel R., Michie P., Carr V., Kelly B. The Feasibility of Videoconferencing for Neuropsychological Assessments of Rural Youth Experiencing Early Psychosis. J. Telemed. Telecare. 2011;17:328–331. doi: 10.1258/jtt.2011.101015.
    1. Werfel K.L., Grey B., Johnson M., Brooks M., Cooper E., Reynolds G., Deutchki E., Vachio M., Lund E.A. Transitioning Speech-Language Assessment to a Virtual Environment: Lessons Learned from the ELLA Study. Lang. Speech Hear. Serv. Sch. 2021;52:769–775. doi: 10.1044/2021_LSHSS-20-00149.
    1. Maresca G., De Cola M.C., Caliri S., De Luca R., Manuli A., Scarcella I., Silvestri G., Bramanti P., Torrisi M., Calabrò R.S., et al. Sicilian Teleneurology Group. Moving towards Novel Multidisciplinary Approaches for Improving Elderly Quality of Life: The Emerging Role of Telemedicine in Sicily. J. Telemed. Telecare. 2019;25:318–324. doi: 10.1177/1357633X17753057.
    1. Sarfo F.S., Ulasavets U., Opare-Sem O.K., Ovbiagele B. Tele-Rehabilitation after Stroke: An Updated Systematic Review of the Literature. J. Stroke Cerebrovasc. Dis. 2018;27:2306–2318. doi: 10.1016/j.jstrokecerebrovasdis.2018.05.013.
    1. Corti C., Oldrati V., Oprandi M.C., Ferrari E., Poggi G., Borgatti R., Urgesi C., Bardoni A. Remote Technology-Based Training Programs for Children with Acquired Brain Injury: A Systematic Review and a Meta-Analytic Exploration. Behav. Neurol. 2019;2019:1346987. doi: 10.1155/2019/1346987.
    1. Agostini M., Moja L., Banzi R., Pistotti V., Tonin P., Venneri A., Turolla A. Telerehabilitation and Recovery of Motor Function: A Systematic Review and Meta-Analysis. J. Telemed. Telecare. 2015;21:202–213. doi: 10.1177/1357633X15572201.
    1. Cardullo S., Gamberini L., Milan S., Mapelli D. Rehabilitation Tool: A Pilot Study on A New Neuropsychological Interactive Training System. Stud. Health Technol. Inform. 2015;219:168–173.
    1. Coleman J.J., Frymark T., Franceschini N.M., Theodoros D.G. Assessment and Treatment of Cognition and Communication Skills in Adults with Acquired Brain Injury via Telepractice: A Systematic Review. Am. J. Speech. Lang. Pathol. 2015;24:295–315. doi: 10.1044/2015_AJSLP-14-0028.
    1. Solana J., Cáceres C., García-Molina A., Opisso E., Roig T., Tormos J.M., Gómez E.J. Improving Brain Injury Cognitive Rehabilitation by Personalized Telerehabilitation Services: Guttmann Neuropersonal Trainer. IEEE J. Biomed. Health Inform. 2015;19:124–131. doi: 10.1109/JBHI.2014.2354537.
    1. Casalini C., Mazzotti S. Problematiche e Prospettive Dell’intervento a Distanza Nei Disturbi Del Neurosviluppo. Psicol. Clin. Dello Svilupp. 2021;3:389–416. doi: 10.1449/100597.
    1. Theodoros D.G. Telerehabilitation for Service Delivery in Speech-Language Pathology. J. Telemed. Telecare. 2008;14:221–224. doi: 10.1258/jtt.2007.007044.
    1. Caso V., Federico A. No Lockdown for Neurological Diseases during COVID-19 Pandemic Infection. Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol. 2020;41:999–1001.
    1. Dayal D. We urgently need guidelines for managing COVID-19 in children with comorbidities. Acta Paediatr. 2020;109:1497–1498. doi: 10.1111/apa.15304.
    1. Sarti D., De Salvatore M., Gazzola S., Pantaleoni C., Granocchio E. So Far so Close: An Insight into Smart Working and Telehealth Reorganization of a Language and Learning Disorders Service in Milan during COVID-19 Pandemic. Neurol. Sci. 2020;41:1659–1662. doi: 10.1007/s10072-020-04481-8.
    1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 5th ed. American Psychiatric Association Publishing; Washington, DC, USA: 2015.
    1. Huc-Chabrolle M., Barthez M.A., Tripi G., Barth’el’emy C., Bonnet-Brilhault F. Psychocognitive and Psychiatric Disorders Associated with Developmental Dyslexia: A Clinical and Scientific Issue. Encephale. 2010;36:172–179. doi: 10.1016/j.encep.2009.02.005.
    1. Catts H.W., Adlof S.M., Hogan T.P., Weismer S.E. Are Specific Language Impairment and Dyslexia Distinct Disorders? J. Speech Lang. Hear. Res. 2005;48:1378–1396. doi: 10.1044/1092-4388(2005/096).
    1. Angelelli P., Marinelli C.V., Iaia M., Putzolu A., Gasperini F., Brizzolara D., Chilosi A.M. Spelling Impairments in Italian Dyslexic Children with and without a History of Early Language Delay. Are There Any Differences? Front. Psychol. 2016;7:527. doi: 10.3389/fpsyg.2016.00527.
    1. Brizzolara D., Chilosi A., Cipriani P., Di Filippo G., Gasperini F., Mazzotti S., Pecini C., Zoccolotti P. Do Phonologic and Rapid Automatized Naming Deficits Differentially Affect Dyslexic Children with and without a History of Language Delay? A Study of Italian Dyslexic Children. Cogn. Behav. Neurol. 2006;19:141–149. doi: 10.1097/01.wnn.0000213902.59827.19.
    1. Brizzolara D., Gasperini F., Pfanner L., Cristofani P., Casalini C., Chilosi A.M. Long-Term Reading and Spelling Outcome in Italian Adolescents with a History of Specific Language Impairment. Cortex. 2011;47:955–973. doi: 10.1016/j.cortex.2011.02.009.
    1. Chilosi A.M., Brizzolara D., Lami L., Pizzoli C., Gasperini F., Pecini C., Cipriani P., Zoccolotti P. Reading and Spelling Disabilities in Children with and without a History of Early Language Delay: A Neuropsychological and Linguistic Study. Child. Neuropsychol. 2009;15:582–604. doi: 10.1080/09297040902927614.
    1. Pecini C., Biagi L., Brizzolara D., Cipriani P., Di Lieto M.C., Guzzetta A., Tosetti M., Chilosi A.M. How Many Functional Brains in Developmental Dyslexia? When the History of Language Delay Makes the Difference. Cogn. Behav. Neurol. 2011;24:85–92. doi: 10.1097/WNN.0b013e318222a4c2.
    1. Tucci R., Savoia V., Bertolo L., Vio C., Tressoldi P.E. Efficacy and Efficiency Outcomes of a Training to Ameliorate Developmental Dyslexia Using the Online Software Reading Trainer®. BPA-Appl. Psychol. Bull. 2015;63:53–60.
    1. Bonacina S., Cancer A., Lanzi P.L., Lorusso M.L., Antonietti A. Improving Reading Skills in Students with Dyslexia: Efficacy of a Sublexical Training with Rhythmic Background. Front. Psychol. 2015;6:1510. doi: 10.3389/fpsyg.2015.01510.
    1. Gori S., Facoetti A. Perceptual Learning as a Possible New Approach for Remediation and Prevention of Developmental Dyslexia. Vision Res. 2014;99:78–87. doi: 10.1016/j.visres.2013.11.011.
    1. van Bergen E., van der Leij A., de Jong P.F. The Intergenerational Multiple Deficit Model and the Case of Dyslexia. Front. Hum. Neurosci. 2014;8:346. doi: 10.3389/fnhum.2014.00346.
    1. Zampolini M., Todeschini E., Bernabeu Guitart M., Hermens H., Ilsbroukx S., Macellari V., Magni R., Rogante M., Scattareggia Marchese S., Vollenbroek M., et al. Tele-Rehabilitation: Present and Future. Ann. Ist. Super. Sanita. 2008;44:125–134.
    1. Pecini C., Spoglianti S., Michetti S., Bonetti S., Di Lieto M.C., Gasperini F., Cristofani P., Bozza M., Brizzolara D., Casalini C., et al. Telerehabilitation in Developmental Dyslexia: Methods of Implementation and Expected Results. Minerva Pediatr. 2018;70:529–538. doi: 10.23736/S0026-4946.16.04426-1.
    1. Tressoldi P.E., Brembati F., Donini R., Iozzino R., Vio C. Treatment of Dyslexia in a Regular Orthography: Efficacy and Efficiency (Cost-Effectiveness), Comparison between Home vs Clinic-Based Treatments. Eur. J. Psychol. 2012;8:375–390. doi: 10.5964/ejop.v8i3.442.
    1. Maggio M.G., Foti Cuzzola M., Calatozzo P., Marchese D., Andaloro A., Calabrò R.S. Improving Cognitive Functions in Adolescents with Learning Difficulties: A Feasibility Study on the Potential Use of Telerehabilitation during COVID-19 Pandemic in Italy. J. Adolesc. 2021;89:194–202. doi: 10.1016/j.adolescence.2021.05.005.
    1. Holmes J., Gathercole S.E. Taking Working Memory Training from the Laboratory into Schools. Educ. Psychol. 2014;34:440–450. doi: 10.1080/01443410.2013.797338.
    1. Johann V.E., Karbach J. Effects of Game-Based and Standard Executive Control Training on Cognitive and Academic Abilities in Elementary School Children. Dev. Sci. 2020;23:e12866. doi: 10.1111/desc.12866.
    1. Dahlin K.I.E. Working Memory Training and the Effect on Mathematical Achievement in Children with Attention Deficits and Special Needs. J. Educ. Learn. 2013;2:118–133. doi: 10.5539/jel.v2n1p118.
    1. Schwaighofer M., Fischer F., Bühner M. Does Working Memory Training Transfer? A Meta-Analysis Including Training Conditions as Moderators. Educ. Psychol. 2015;50:138–166. doi: 10.1080/00461520.2015.1036274.
    1. Diamond A. Executive Functions. Annu. Rev. Psychol. 2013;64:135–168. doi: 10.1146/annurev-psych-113011-143750.
    1. Holmes J., Gathercole S.E., Dunning D.L. Adaptive Training Leads to Sustained Enhancement of Poor Working Memory in Children. Dev. Sci. 2009;12:F9–F15. doi: 10.1111/j.1467-7687.2009.00848.x.
    1. Consensus Conferenfe DSA. Documento D’intesa, PARCC. 2011. [(accessed on 12 March 2022)]. Available online: .
    1. Casalini C., Pecini C., Zaccaria S., Orsolini L., Brizzolara D. Telepsychology’ and Specific Learning Disabilities in COVID-19 Time: A Critical Review. Psicol. Clin. Dello Svilupp. 2020;24:361–374.
    1. Peijnenborgh J.C.A.W., Hurks P.M., Aldenkamp A.P., Vles J.S.H., Hendriksen J.G.M. Efficacy of Working Memory Training in Children and Adolescents with Learning Disabilities: A Review Study and Meta-Analysis. Neuropsychol. Rehabil. 2016;26:645–672. doi: 10.1080/09602011.2015.1026356.
    1. MemoRAN in RIDInet Platform, Anastatis, Bologna, Italy. [(accessed on 15 April 2019)]. Available online:
    1. Wechsler D. WPPSI-III Administration and Scoring Manual. Psychological Corporation; San Antonio, TX, USA: 2002.
    1. Bisiacchi P.S., Cendron M., Gugliotta M., Tressoldi P.E., Vio C. Batteria Di Valutazione Neuropsicologica per l’Età Evolutiva. BNV 5-11. Erickson; Trento, Italy: 2005.
    1. IRCCS Stella Maris High Frequency Bisyllabic Word List Repetition Test. 2017. in press .
    1. Korkman M., Kirk U., Kemp S. NEPSY-II. Italian Adaptation. Giunti OS; Firenze, Italy: 2011.
    1. Roid G.H., Koch C. Handbook of Nonverbal Assessment. Springer International Publishing; Cham, Switzerland: 2017. Leiter-3: Nonverbal Cognitive and Neuropsychological Assessment; pp. 127–150.
    1. Marzocchi G.M., Re A.M., Cornoldi C. BIA. Batteria Italiana per l’ADHID per La Valutazione Dei Bambini Con Deficit Di Attenzione-Iperattività. Edizioni Erickson; Trento, Italy: 2010.
    1. De Luca M., Di Filippo G., Judica A., Spinelli D., Zoccolotti P. Test. Di Denominazione Rapida e Ricerca Visiva Di Colori, Figure e Numeri. IRCCS Fondazione Santa Lucia; Roma, Italy: 2005.
    1. Gioia G.A., Isquith P.K., Guy S.C., Kenworthy L. BRIEF2—Behavior Rating Inventory of Executive Function. Hogrefe; Firenze, Itlay: 2009.
    1. Wechsler D. Wechsler Intelligence Scale for Children—Fourth Edition Technical and Interpretive Manual. Psychological Corporation; San Antonio, TX, USA: 2003.
    1. Palladino P. Uno Strumento per Esaminare La Memoria Di Lavoro Verbale in Bambini Di Scuola Elementare: Taratura e Validità. Psicol. Clin. Dello Svilupp. 2005;9:129–150.
    1. Cornoldi C., Miato L., Molin A., Poli S. PRCR—2/2009 Prove Di Prerequisito per La Diagnosi Delle Difficoltà Della Lettura e Scrittura. Giunti OS; Firenze, Italy: 2009.
    1. Bonifacci P., Tobia V., Lami L., Snowling M. ALCE. Assessment Di Lettura e Comprensione per l’Età Evolutiva. Hogrefe; Göttingen, Germany: 2014.
    1. Sartori G., Job R., Tressoldi P.E. DDE-2. Batteria per La Valutazione Della Dislessia e Della Disortografia Evolutiva (Battery for the Assessment of Developmental Dyslexia and Dysorthographia) Giunti OS; Firenze, Italy: 2007.
    1. Diamond A., Lee K. Interventions Shown to Aid Executive Function Development in Children 4 to 12 Years Old. Science. 2011;333:959–964. doi: 10.1126/science.1204529.
    1. Di Lieto M.C., Brovedani M.C., Pecini P., Chilosi C., Belmonti A.M., Fabbro V., Cioni G. Spastic Diplegia in Preterm-Born Children: Executive Function Impairment and Neuroanatomical Correlates. Res. Dev. Disabil. 2017;61:116–126. doi: 10.1016/j.ridd.2016.12.006.
    1. Di Lieto M.C., Inguaggiato M.C., Castro E., Cecchi E., Cioni F., Dell’omo G., Dario P. Educational Robotics Intervention on Executive Functions in Preschool Children: A Pilot Study. Comput. Hum. Behav. 2017;71:16–23. doi: 10.1016/j.chb.2017.01.018.
    1. Cohen D.K. Teaching Practice: Plus Ça Change. Michigan State University; East Lansing, MI, USA: 1988.
    1. McCue M., Fairman A., Pramuka M. Enhancing Quality of Life through Telerehabilitation. Phys. Med. Rehabil. Clin. N. Am. 2010;21:195–205. doi: 10.1016/j.pmr.2009.07.005.
    1. Ghidoni E., Angelini D. La Dislessia Negli Adolescenti e Negli Adulti. Ann. Della Pubblica Istr. 2011;4:119–127.
    1. Spencer-Smith M., Klingberg T. Correction: Benefits of a Working Memory Training Program for Inattention in Daily Life: A Systematic Review and Meta-Analysis. PLoS ONE. 2016;11:e0167373. doi: 10.1371/journal.pone.0167373.
    1. Flaugnacco E., Lopez L., Terribili C., Montico M., Zoia S., Schön D. Music Training Increases Phonological Awareness and Reading Skills in Developmental Dyslexia: A Randomized Control Trial. PLoS ONE. 2015;10:e0138715. doi: 10.1371/journal.pone.0138715.
    1. Zoccolotti P., de Jong P.F., Spinelli D. Editorial: Understanding Developmental Dyslexia: Linking Perceptual and Cognitive Deficits to Reading Processes. Front. Hum. Neurosci. 2016;10:140. doi: 10.3389/fnhum.2016.00140.
    1. De Cola M.C., Maresca G., D’Aleo G., Carnazza L., Giliberto S., Maggio M.G., Bramanti A., Calabrò R.S. Teleassistance for Frail Elderly People: A Usability and Customer Satisfaction Study. Geriatr. Nurs. 2020;41:463–467. doi: 10.1016/j.gerinurse.2020.01.019.
    1. Manuli A., Maggio M.G., Tripoli D., Gullì M., Cannavò A., La Rosa G., Sciarrone F., Avena G., Calabrò R.S. Patients’ Perspective and Usability of Innovation Technology in a New Rehabilitation Pathway: An Exploratory Study in Patients with Multiple Sclerosis. Mult. Scler. Relat. Disord. 2020;44:102312. doi: 10.1016/j.msard.2020.102312.
    1. Norton E.S., Wolf M. Rapid Automatized Naming (RAN) and Reading Fluency: Implications for Understanding and Treatment of Reading Disabilities. Annu. Rev. Psychol. 2012;63:427–452. doi: 10.1146/annurev-psych-120710-100431.
    1. Resquín F., Cuesta Gómez A., Gonzalez-Vargas J., Brunetti F., Torricelli D., Molina Rueda F., Cano de la Cuerda R., Miangolarra J.C., Pons J.L. Hybrid Robotic Systems for Upper Limb Rehabilitation after Stroke: A Review. Med. Eng. Phys. 2016;38:1279–1288. doi: 10.1016/j.medengphy.2016.09.001.
    1. Chacko A., Uderman J., Feirsen N., Bedard A.C., Marks D. Learning and Cognitive Disorders: Multidisciplinary Treatment Approaches. Child. Adolesc. Psychiatr. Clin. N. Am. 2013;22:457–477. doi: 10.1016/j.chc.2013.03.006.
    1. Klingberg T., Fernell E., Olesen P.J., Johnson M., Gustafsson P., Dahlström K. Computerized Training of Working Memory in Children with ADHD-a Randomized, Controlled Trial. J. Am. Acad. Child. Adolesc. Psychiatry. 2005;44:177–186. doi: 10.1097/00004583-200502000-00010.
    1. Kuusisaari H. Teachers at the Zone of Proximal Development: Collaboration Promoting or Hindering the Development Process. Teach. Teach. Educ. 2014;43:46–57. doi: 10.1016/j.tate.2014.06.001.
    1. Thorell L.B., Lindqvist S., Bergman Nutley S., Bohlin G., Klingberg T. Training and Transfer Effects of Executive Functions in Preschool Children. Dev. Sci. 2009;12:106–113. doi: 10.1111/j.1467-7687.2008.00745.x.

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