Use of Fourier-domain OCT to detect retinal nerve fiber layer degeneration in Parkinson's disease patients
M Satue, E Garcia-Martin, I Fuertes, S Otin, R Alarcia, R Herrero, M P Bambo, L E Pablo, F J Fernandez, M Satue, E Garcia-Martin, I Fuertes, S Otin, R Alarcia, R Herrero, M P Bambo, L E Pablo, F J Fernandez
Abstract
Purpose: To demonstrate axonal loss in the retinal nerve fiber layer (RNFL) of patients with Parkinson's disease (PD) and to evaluate the ability of Fourier-domain optical coherence tomography (OCT) to detect RNFL degeneration and retinal thinning in these patients.
Methods: PD patients (n=100) and healthy subjects (n=100) were included in the study and underwent visual acuity, color vision, and OCT examinations using two next-generation Fourier-domain devices (Spectralis and Cirrus). Differences in the RNFL thicknesses were compared between patients and controls.
Results: RNFL thicknesses were significantly reduced in PD patients compared with healthy subjects, especially those obtained using the Spectralis OCT, in the inferotemporal quadrant (155.6±16.5 μm in healthy eyes vs 142.1±24.9 μm in patients, P=0.040) and in the superotemporal quadrant (142.6±20.9 μm in healthy eyes vs 132.77±18.6 μm in PD patients, P=0.046). Significant differences were observed between controls and patients in relation to mean macular thickness (P=0.031), foveal thickness (P=0.030), and inferior outer thickness (P=0.019).
Conclusion: PD is associated with RNFL loss and retinal thinning, which is detectable by Fourier-domain OCT measurements.
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Source: PubMed