Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy

Abstract

Diabetic retinopathy (DR) classically presents with micro-aneurysms, small haemorrhages and/or lipoprotein exudates. Several studies have indicated that neural loss occurs in DR even before vascular damage can be observed. This study evaluated the possible relationship between structure (spectral domain-optical coherence tomography) and function (Rarebit visual field test) in patients with type 1 diabetes mellitus and no or minimal diabetic retinopathy (DR). Results demonstrated loss of macular visual function and corresponding thinning of the ganglion cell layer (GCL) in the pericentral area of the macula of diabetic patients (Rs = 0.65, p < 0.001). In multivariable logistic regression analysis, GCL thickness remained an independent predictor of decreased visual function (OR 1.5, 95% CI 1.1-2.1). Early DR seems to include a neurodegenerative component.

Copyright © 2010 Elsevier Ltd. All rights reserved.

Figures

Figure 1

The intraretinal surfaces in a macular B-scan as indicated by the colored lines and the corresponding retinal layers in figures. The retinal surfaces are segmented fully automatically using an inherently 3D approach. 1/ retinal nerve fiber layer, 2/ ganglion cell layer, 3/ inner plexiform layer, 4/ inner nuclear layer, 5/ outer plexiform layer, 6/ outer nuclear layer + inner segments, 7/ outer segments, 8/ retinal pigment epithelium.

Figure 2. Scatter-plot of pericentral GCL thickness versus MHR in type 1 diabetes patients