Hyaluronic acid gel fillers in the management of facial aging

Fredric S Brandt, Alex Cazzaniga, Fredric S Brandt, Alex Cazzaniga

Abstract

Time affects facial aging by producing cellular and anatomical changes resulting in the consequential loss of soft tissue volume. With the advent of new technologies, the physician has the opportunity of addressing these changes with the utilization of dermal fillers. Hyaluronic acid (HA) dermal fillers are the most popular, non-permanent injectable materials available to physicians today for the correction of soft tissue defects of the face. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation. HA dermal fillers are safe and effective. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle, has expanded the popularity of these fillers. In the US, there are currently eight HA dermal fillers approved for commercialization by the Food and Drug Administration (FDA). This article reviews the innate properties of FDA-approved HA fillers and provides an insight on future HA products and their utilization for the management of the aging face.

References

    1. Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:
    1. Balazs EA, Denlinger JL. Clinical uses of Hyaluronan. Ciba Found Symp. 1989;143:265.
    1. Bousquet MT, Agerup B. Restylane lip implantation: European experience. Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery. 1999;2:172–6.
    1. Brandt F, Cazzaniga A. Hyaluronic acid fillers: Restylane and Perlane. In: Maas CS, editor. Facial Plastic Surgery Clinics of North America. Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed.
    1. Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement. Dermatol Surg. 2005;31:893–7.
    1. Brown LH, Frank PJ. What’s new in fillers? J Drugs Dermatol. 2003;2:250–3.
    1. Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox) and nonanimal sourced hyaluronic acid (NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A. Dermatol Surg. 2003;29:802–9.
    1. Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners. Dermatol Surg. 2005;31:1–5.
    1. Coleman KR, Carruthers J. Combination therapy with Botox and fillers: the new rejuvenation paradigm. Dermatol Ther. 2006;16:177–88.
    1. Coleman SR, Grover R. The anatomy of the aging face: volume loss and changes in 3-dimensional topography. Aesthetic Surgery Journal. 2006 Jan–Feb;:s4–s9.
    1. De Maio M. the minimal approach: an innovation on facial cosmetic procedure. Aesthetic Plast Surg. 2004;28:295–300.
    1. Duranti F, Salti G, Bovani B, et al. Injectable hyaluronic acid gel for soft tissue augmentation, a clinical and histological study. Dermatol Surg. 1998;24:1317–25.
    1. Fernández-Cossío S, Castaño-Oreja MT. Biocompatibiliy of two novel dermal fillers: histological evaluation of implants of a hyaluronic acid filler and a polyacrylamide filler. Plast Reconstr Surg. 2006;117:1789–96.
    1. Golberg RA, Fiaschetti D. Filling the periorbital hollows with hyaluronic acid gel: initial experience with 244 injections. Ophthal Plast Reconstr Surg. 2006;22:335–41.
    1. Hirsch RJ, Lupo M, Cohen JL, Duffy D. Case Reports: delayed presentation of impending necrosis following soft tissue augmentation with hyaluronic acid and successful management with hyaluronidase. J Drugs Dermatol. 2007;6:325–8.
    1. Hönig JF, Brink U, Korabiowska M. Severe granulomatous allergic tissue reaction after hyaluronic acid injection in the treatment of facial lines and its surgical correction. J Craniof Surg. 2003;14:197–200.
    1. Johl SS, Burgett RA. Dermal filler agents: a practical review. Curr Opin Ophthalmol. 2006;14:471–9.
    1. Kane MAC. Advanced techniques for using Restylane in the lower eyelids. Aesthetic Surg. 2007;27:90–2.
    1. Kelly PE. Injectable success: from fillers to Botox. Facial Plast Surg. 2007;23:7–18.
    1. Little JW. Volumetric perceptions in midfacial aging with altered priorities for rejuvenation. Plast Reconstr Surg. 2000;105:252–66.
    1. Lowe NJ, Maxwell CA, Patanaik R. Adverse reactions to dermal fillers: review. Dermatol Surg. 2005;31:1616–25.
    1. Lupo MP. Hyaluronic acid fillers in facial rejuvenation. Semin Cutan Med Surg. 2006;25:122–6.
    1. Matarasso SL, Carruthers JD, Jewell ML the Restylane Consensus Group. Consensus recommendations for soft tissue augmentation with nonanimal stabilized hyaluronic acid (Restylane) Plast Reconstr Surg. 2006;117:3S–34S.
    1. Monheit GD. Hylaform: a new hyaluronic acid filler in soft tissue augmentation. Facial Plast Surg. 2004;20:153–7.
    1. Monheit GD, Coleman KM. Hyaluronic acid fillers. Dermatol Ther. 2006;16:141–50.
    1. Narins RS, Bowman PH. Injectable skin fillers. Clin Plast Surg. 2005;32:151–62.
    1. Narins RS, Brandt FS, Leyden J, et al. A randomized, double-blind, multicenter comparison of the efficacy and tolerability of Restylane versus Zyplast for the correction of nasolabial folds. Dermatol Surg. 2003;29:588–95.
    1. Rao J, Chi GC, Goldman MP. Clinical comparison between two hyaluronic acid-derived fillers in the treatment of nasolabial folds: Hylaform versus Restylane. Dermatol Surg. 2005;31:1587–90.
    1. Schanz S, Schippert W, Ulmer A, et al. Arterial embolization caused by injection of hyaluronic acid (Restylane) Br J Dermatol. 2002;146:928–9.
    1. Simoni RD, Hill RL, Vaughan M, et al. JBC Centennial. The discovery of hyaluronan by Karl Meyer. J Biol Chem. 2002;277:61–2.
    1. Soparkar CN, Patrinely JR, Tschen J. Erasing Restylane. Ophthal Plast Reconstr Surg. 2004;20:317–8.
    1. Stennert E. Why does the frontalis muscle “never” come back? Functional organization of the mimic musculature. Eur Arch Otorhinolaryngol. 1994:S91–5.
    1. Wang F, Garza L, Kang S, et al. In vivo stimulation of De Novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin. Arch Dermatol. 2007;143:155–63.
    1. Winnington P. Tuning-In to the demand for dermal fillers. Practical Dermatology. 2007:36–9.
    1. Wise JB, Greco T. Injectable treatments for the aging face. Facial Plast Surg. 2006;22:140–6.

Source: PubMed

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