The effects of long-term oral benfotiamine supplementation on peripheral nerve function and inflammatory markers in patients with type 1 diabetes: a 24-month, double-blind, randomized, placebo-controlled trial

David A Fraser, Lien M Diep, Inger Anette Hovden, Kristian B Nilsen, Kari Anne Sveen, Ingebjørg Seljeflot, Kristian F Hanssen, David A Fraser, Lien M Diep, Inger Anette Hovden, Kristian B Nilsen, Kari Anne Sveen, Ingebjørg Seljeflot, Kristian F Hanssen

Abstract

Objective: To study the effects of long-term oral benfotiamine supplementation on peripheral nerve function and soluble inflammatory markers in patients with type 1 diabetes.

Research design and methods: The study randomly assigned 67 patients with type 1 diabetes to receive 24-month benfotiamine (300 mg/day) or placebo supplementation. Peripheral nerve function and levels of soluble inflammatory variables were assessed at baseline and at 24 months.

Results: Fifty-nine patients completed the study. Marked increases in whole-blood concentrations of thiamine and thiamine diphosphate were found in the benfotiamine group (both P < 0.001 vs. placebo). However, no significant differences in changes in peripheral nerve function or soluble inflammatory biomarkers were observed between the groups.

Conclusions: Our findings suggest that high-dose benfotiamine (300 mg/day) supplementation over 24 months has no significant effects upon peripheral nerve function or soluble markers of inflammation in patients with type 1 diabetes.

Trial registration: ClinicalTrials.gov NCT00117026.

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Source: PubMed

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