Computer decision support systems for asthma: a systematic review

Patricia Matui, Jeremy C Wyatt, Hilary Pinnock, Aziz Sheikh, Susannah McLean, Patricia Matui, Jeremy C Wyatt, Hilary Pinnock, Aziz Sheikh, Susannah McLean

Abstract

Background: Increasing use of electronic health records offers the potential to incorporate computer decision support systems (CDSSs) to prompt evidence-based actions within routine consultations.

Aim: To synthesise the evidence for the use of CDSSs by professionals managing people with asthma.

Materials and methods: We systematically searched Medline, Embase, Health Technology Assessment, Cochrane and Inspec databases (1990 to April 2012, no language restrictions) for trials, and four online repositories for unpublished studies. We also wrote to authors. Eligible studies were randomised controlled trials of CDSSs supporting professional management of asthma. Studies were appraised (Cochrane Risk of Bias Tool) and findings synthesised narratively.

Results: A total of 5787 articles were screened, and eight trials were found eligible, with six at high risk of bias. Overall, CDSSs for professionals were ineffective. Usage of the systems was generally low: in the only trial at low risk of bias the CDSS was not used at all. When a CDSS was used, compliance with the advice offered was also low. However, if actually used, CDSSs could result in closer guideline adherence (improve investigating, prescribing and issuing of action plans) and could improve some clinical outcomes. The study at moderate risk of bias showed increased prescribing of inhaled steroids.

Conclusions: The current generation of CDSSs is unlikely to result in improvements in outcomes for patients with asthma because they are rarely used and the advice is not followed. Future decision support systems need to align better with professional workflows so that pertinent and timely advice is easily accessible within the consultation.

Figures

Figure 1
Figure 1
Theoretical model showing how a computer decision support system can improve asthma outcomes.
Figure 2
Figure 2
PRISMA flow diagram.

References

    1. Global Initiative for Asthma. The global strategy for asthma management and prevention, 2012. Available from (accessed September 2013).
    1. Patel S, Jarvelin M, Little M. Systematic review of worldwide variations of the prevalence of wheezing symptoms in children. Environ Health. 2008;7:57.
    1. Beasley R for the International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema. Lancet. 1998;351:1225–1232.
    1. Anandan C, Nurmatov U, van Schayck OC, Sheikh A. Is the prevalence of asthma declining? Systematic review of epidemiological studies. Allergy. 2009;65:152–167.
    1. Gupta R, Sheikh A, Strachan DP, Anderson HR. Burden of allergic disease in the UK: secondary analyses of national databases. Clin Exp Allergy. 2004;34:520–526.
    1. National Heart, Lung and Blood Institute. Guidelines for the diagnosis and management of asthma, 2007. Available from (accessed September 2013).
    1. British Thoracic Society/Scottish Intercollegiate Guideline Network. British guideline on the management of asthma, 2012. Available from (accessed September 2013).
    1. Canadian Thoracic Society. CTS 2012 Guideline Update: diagnosis and management of asthma in preschoolers, children and adults. Available from (accessed September 2013).
    1. Rabe KF, Adachi M, Lai CKW, Soriano JB, Vermeire PA, Weiss KB. Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol. 2004;114:40–47.
    1. Haughney J, Barnes G, Partridge M, Cleland J. The Living & Breathing study: a study of patients' views of asthma and its treatment. Prim Care Resp J. 2004;13:28–35.
    1. Stallberg B, Lisspers K, Hasselgren M, Janson C, Johansson G, Svardsudd K. Asthma control in primary care in Sweden: a comparison between 2001 and 2005. Prim Care Respir J. 2009;18:279–286.
    1. Cabana MD, Rand CS, Powe NR, Wu AW, Abboud PC, Rubin HR. Why don't physicians follow clinical practice guidelines? A framework for improvement. JAMA. 1999;282:1458–1465.
    1. Wiener-Oglilvie S, Pinnock H, Huby G, Sheikh A, Partridge MR, Gillies J. Do practices comply with key recommendations of the British Asthma Guideline? If not, why not? Prim Care Respir J. 2007;16:369–377.
    1. Robertson A, Cresswell K, Takian A, Petrakaki D, Crowe S, Cornford T. Implementation and adoption of nationwide electronic health records in secondary care in England: qualitative analysis of interim results from a prospective national evaluation. BMJ. 2010;341:c4564.
    1. Sheikh A, Cornford T, Barber N, Avery A, Takian A, Lichtner V. Implementation and adoption of nationwide electronic health records in secondary care in England: final qualitative results from prospective national evaluation in "early adopter" hospitals. BMJ. 2011;343:d6054.
    1. Higgins J, Green S.Cochrane Handbook for Systematic Reviews of Interventions The Cochrane Collaboration; 2011 . (accessed September 2013).
    1. Wyatt J, Spiegelhalter D. Field trials of medical decision-aids: potential problems and solutions. Proc Annu Symp Comput Appl Med Care. 1991. pp. 3–7.
    1. Haynes RB, Wilczynski NL, for the CDSS SystematicReviewTeam Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: methods of a decision-maker-researcher partnership systematic review. Implement Sci. 2010;5:12.
    1. Reddel HK, Taylor DR, Bateman ED, Boulet LP, Boushey HA, Busse WW. An Official American Thoracic Society/European Respiratory Society Statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med. 2009;180:59–99.
    1. Bell LM, Grundmeier R, Localio R, Zorc J, Fiks AG, Zhang X. Electronic health record-based decision support to improve asthma care: a cluster-randomized trial. Pediatrics. 2010;125:e770–e777.
    1. Eccles M, McColl E, Steen N, Rousseau N, Grimshaw J, Parkin D. Effect of computerised evidence based guidelines on management of asthma and angina in adults in primary care: cluster randomised controlled trial. BMJ. 2002;325:941.
    1. Fiks AG, Hunter KF, Localio AR, Grundmeier RW, Bryant-Stephens T, Luberti AA. Impact of electronic health record-based alerts on influenza vaccination for children with asthma. Pediatrics. 2009;124:159–169.
    1. Kuilboer MM, van Wijk MA, Mosseveld M, van der Does E, de Jongste JC, Overbeek SE. Computed critiquing integrated into daily clinical practice affects physicians' behavior—a randomized clinical trial with AsthmaCritic. Methods Inf Me. 2006;45:447–454.
    1. Martens JD, van der Weijden T, Severens JL, de Clercq PA, de Bruijn DP, Kester AD. The effect of computer reminders on GPs' prescribing behaviour: a cluster-randomised trial. Int J Med Inform. 2007;76:S403–S416.
    1. McCowan C, Neville RG, Ricketts IW, Warner FC, Hoskins G, Thomas GE. Lessons from a randomized controlled trial designed to evaluate computer decision support software to improve the management of asthma. Inform Health Social Care. 2001;26:191–201.
    1. Plaza V, Cobos A, Ignacio-Garcia JM, Molina J, Bergoñón S, García-Alonso F. Cost-effectiveness of an intervention based on the Global INitiative for Asthma (GINA) recommendations using a computerized clinical decision support system: a physicians randomized trial [Spanish] Med Clin. 2005;124:201–206.
    1. Tierney WM, Overhage JM, Murray MD, Harris LE, Zhou XH, Eckert GJ. Can computer-generated evidence-based care suggestions enhance evidence-based management of asthma and chronic obstructive pulmonary disease? A randomized controlled trial. Health Services Res. 2005;40:477–497.
    1. Martens JD, van der Aa A, Panis B, van der Weijden T, Winkens RA, Severens JL. Design and evaluation of a computer reminder system to improve prescribing behaviour of GPs. Stud Health Technol Inform. 2006;124:617–623.
    1. Durieux P, Trinquart L, Colombet I, Niès J, Walton R, Rajeswaran A.
    1. Steen N, Hutchinson A, McColl E, Eccles MP, Hewison J, Meadows KA. Development of a symptom based outcome measure for asthma. BMJ. 1994;309:1065–1068.
    1. Juniper EF, Buist AS, Cox FM, Ferrie PJ, King DR. Validation of a standardized version of the Asthma Quality of Life Questionnaire. Chest. 1999;115:1265–1270.
    1. Ferrer M, Alonso J, Prieto L, Plaza V, Monsó E, Marrades R. Valididty and reliability of the St George's Respiratory Questionnaire after adaptation to a different language aand culture: the Spanish example. Eur Respir J. 1996;9:1160–1166.
    1. Guyatt GH, Berman LB, Townsend M, Pugsley WO, Chanbers LW. A measure of quality of life for clinical trials in chronic lung disease. Thorax. 1987;42:773–778.
    1. Juniper E, Guyatt GH, Ferrie PJ, Griffith LE. Measuring quality of life in asthma. Am Rev Resp Dis. 1993;147:832–838.
    1. Car J, Black A, Anandan C, Cresswell K, Pagliari C, McKinstry B. The Impact of eHealth on the Quality & Safety of Healthcare. Connecting for Health Evaluation Programme 001 Report. University of Birmingham: Birmingham, UK; 2011.
    1. Roshanov PS, Misra S, Gerstein HC, Garg AX, Sebaldt RJ, Mackay JA, for the CCDSS SystematicReviewTeam Computerized clinical decision support systems for chronic disease management: a decision-maker-researcher partnership systematic review. Implement Sci. 2011;6:92.
    1. Sahota N, Lloyd R, Ramakrishna A, Mackay JA, Prorok JC, Weise-Kelly L, for the CCDSS SystematicReviewTeam. Computerized clinical decision support systems for acute care management: a decision-maker-researcher partnership systematic review of effects on process of care and patient outcomes. Implement Sci. 2011;6:91.
    1. Nieuwlaat R, Connolly SJ, Mackay JA, Weise-Kelly L, Navarro T, Wilczynski NL, for the CCDSS SystematicReviewTeam Computerized clinical decision support systems for therapeutic drug monitoring and dosing: a decision-maker-researcher partnership systematic review. Implement Sci. 2011;6:90.
    1. Hemens BJ, Holbrook A, Tonkin M, Mackay JA, Weise-Kelly L, Navarro T, for the CCDSS SystematicReviewTeam Computerized clinical decision support systems for drug prescribing and management: a decision-maker-researcher partnership systematic review. Implement Sci. 2011;6:89.
    1. Roshanov PS, You JJ, Dhaliwal J, Koff D, Mackay JA, Weise-Kelly L, for the CCDSS SystematicReviewTeam Can computerized clinical decision support systems improve practitioners' diagnostic test ordering behavior? A decision-maker-researcher partnership systematic review. Implement Sci. 2011;6:88.
    1. Souza NM, Sebaldt RJ, Mackay JA, Prorok JC, Weise-Kelly L, Navarro T, for the CCDSS SystematicReviewTeam Computerized clinical decision support systems for primary preventive care: a decision-maker-researcher partnership systematic review of effects on process of care and patient outcomes. Implement Sci. 2011;6:87.
    1. Ryan D, Price D, Musgrave SD, Malhotra S, Lee AJ, Ayansina D. Clinical and cost effectiveness of mobile phone supported self monitoring of asthma: multicentre randomised controlled trial. BMJ. 2012;344:e1756.
    1. Roshanov PS, Fernandes N, Wilczynski JM, Hemens BJ, You JJ, Handler SM. Features of effective computerised clinical decision support systems: meta-regression of 162 randomised trials. BMJ. 2013;346:f657.
    1. Hayward J, Thomson F, Milne H, Buckingham S, Sheikh A, Fernando B. 'Too much, too late': mixed methods multi-channel video recording study of computerized decision support systems and GP prescribing. J Am Med Inform Assoc. 2013;7:7.
    1. Kawamoto K, Houlihan CA, Balas EA, Lobach DF. Improving clinical practice using clinical decision support systems: a systematic review of trials to identify features critical to success. BMJ. 2005;330:765–768.
    1. Garg AX, Adhikari NKJ, McDonald H, Rosas-Arellano MP, Devereaux PJ, Beyene J. Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic review. JAMA. 2005;293:1223–1238.
    1. Berlin A, Sorani M, Sim I. A taxonomic description of computer-based clinical decision support systems. J Biomed Inform. 2006;39:656–667.

Source: PubMed

3
Abonneren