Reduction of immune activation with chloroquine therapy during chronic HIV infection
Shannon M Murray, Carrie M Down, David R Boulware, William M Stauffer, Winston P Cavert, Timothy W Schacker, Jason M Brenchley, Daniel C Douek, Shannon M Murray, Carrie M Down, David R Boulware, William M Stauffer, Winston P Cavert, Timothy W Schacker, Jason M Brenchley, Daniel C Douek
Abstract
Increased levels of activated T cells are a hallmark of the chronic stage of human immunodeficiency virus (HIV) infection and are highly correlated with HIV disease progression. We evaluated chloroquine (CQ) as a potential therapy to reduce immune activation during HIV infection. We found that the frequency of CD38(+) HLA-DR(+) CD8 T cells, as well as Ki-67 expression in CD8 and CD4 T cells, was significantly reduced during CQ treatment. Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals.
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Source: PubMed