Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity
Elvira Haas, Indranil Bhattacharya, Eugen Brailoiu, Marlen Damjanović, G Cristina Brailoiu, Xin Gao, Laurence Mueller-Guerre, Nicole A Marjon, André Gut, Roberta Minotti, Matthias R Meyer, Kerstin Amann, Emerita Ammann, Ana Perez-Dominguez, Michele Genoni, Deborah J Clegg, Nae J Dun, Thomas C Resta, Eric R Prossnitz, Matthias Barton, Elvira Haas, Indranil Bhattacharya, Eugen Brailoiu, Marlen Damjanović, G Cristina Brailoiu, Xin Gao, Laurence Mueller-Guerre, Nicole A Marjon, André Gut, Roberta Minotti, Matthias R Meyer, Kerstin Amann, Emerita Ammann, Ana Perez-Dominguez, Michele Genoni, Deborah J Clegg, Nae J Dun, Thomas C Resta, Eric R Prossnitz, Matthias Barton
Abstract
We found that the selective stimulation of the intracellular, transmembrane G protein-coupled estrogen receptor (GPER), also known as GPR30, acutely lowers blood pressure after infusion in normotensive rats and dilates both rodent and human arterial blood vessels. Stimulation of GPER blocks vasoconstrictor-induced changes in intracellular calcium concentrations and vascular tone, as well as serum-stimulated cell proliferation of human vascular smooth muscle cells. Deletion of the GPER gene in mice abrogates vascular effects of GPER activation and is associated with visceral obesity. These findings suggest novel roles for GPER in protecting from cardiovascular disease and obesity.
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Source: PubMed